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Current Psychiatry Research and Reviews

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ISSN (Print): 2666-0822
ISSN (Online): 2666-0830

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Review Article

Alternative Approaches for the Management of Autism: A Narrative Review

Author(s): Nikhila Shekhar, Sakshi Tyagi and Ajit Kumar Thakur*

Volume 20, Issue 1, 2024

Published on: 07 February, 2023

Page: [14 - 36] Pages: 23

DOI: 10.2174/2666082219666230106143424

Price: $65

Abstract

Autism, a neurodevelopment disorder that was regarded as insignificant in the past is thereby now recognized as a major problem with an increasing prevalence over the past 50 years affecting 1 out of every 160 children worldwide. Recent accumulating evidence indicates that autism is a consequence of the fusion of environmental, genetic, and epigenetic components. Due to the lack of effective pharmacotherapy, alternative approaches are being explored for their beneficial effect on autistic symptoms. A literature review was performed identifying previously published clinical studies that were set up as an alternative therapy for alleviating the symptoms of autism. The data were collected from PubMed and Google Scholar databases. A total of 13 kinds of interventions including video modelling, play therapy, music therapy, yoga, social skills training, sensory integration (SIT), scalp acupuncture, medical clowning, animal-assisted activity, theatre-based intervention, Tai Chu Chuan training, novel mattress technology, and magnetic resonance imaging were found to be affecting the symptoms associated with autism. From sufficient clinical evidence, it was estimated that alternative approaches such as music therapy and play therapy have the most beneficial effect in mitigating the symptoms to an extent.

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[1]
Kanner L. Autistic disturbances of affective contact. Acta Paedopsychiatr 1968; 35(4): 100-36.
[PMID: 4880460]
[2]
Autism Spectrum Disorder. National Institute of Mental Health. Available from: https://www.nimh.nih.gov/health/topics/autism-spectrum-disorders-asd
[3]
Kim KC, Gonzales EL, Lázaro MT, et al. Clinical and neurobiological relevance of current animal models of autism spectrum disorders. Biomol Ther 2016; 24(3): 207-43.
[http://dx.doi.org/10.4062/biomolther.2016.061] [PMID: 27133257]
[4]
Autism Spectrum Disorders. World Health Organization. Available from: https://www.who.int/news-room/fact-sheets/detail/autism-spectrum-disorders
[5]
Doernberg E, Hollander E. Neurodevelopmental disorders (ASD and ADHD): DSM-5, ICD-10, and ICD-11. CNS Spectr 2016; 21(4): 295-9.
[http://dx.doi.org/10.1017/S1092852916000262] [PMID: 27364515]
[6]
Johnson CP, Myers SM. Identification and evaluation of children with autism spectrum disorders. Pediatrics 2007; 120(5): 1183-215.
[http://dx.doi.org/10.1542/peds.2007-2361]
[7]
Bae SM, Hong JY. The Wnt signaling pathway and related therapeutic drugs in autism spectrum disorder. Clin Psychopharmacol Neurosci 2018; 16(2): 129-35.
[http://dx.doi.org/10.9758/cpn.2018.16.2.129] [PMID: 29739125]
[8]
Kaplan SS. Kaplan and Sadock's synopsis of psychiatry: Behavioral sciences/clinical psychiatry, 10th edition. Indian J Psychiatry 2009; 51(4): 331.
[9]
Ecker C. Autism biomarkers for more efficacious diagnosis. Biomarkers Med 2011; 5(2): 193-5.
[http://dx.doi.org/10.2217/bmm.11.13] [PMID: 21473722]
[10]
Missouri Autism Guidelines Initiative: Consensus Publication. Available from: https://www.autismguidelines.dmh.mo.gov/
[11]
Brian JA, Zwaigenbaum L, Ip A. Standards of diagnostic assessment for autism spectrum disorder. Paediatr Child Health 2019; 24(7): 444-51.
[http://dx.doi.org/10.1093/pch/pxz117] [PMID: 31660042]
[12]
Kamp-Becker I, Ghahreman M, Heinzel-Gutenbrunner M, Peters M, Remschmidt H, Becker K. Evaluation of the revised algorithm of Autism Diagnostic Observation Schedule (ADOS) in the diagnostic investigation of high-functioning children and adolescents with autism spectrum disorders. Autism 2013; 17(1): 87-102.
[http://dx.doi.org/10.1177/1362361311408932] [PMID: 21610187]
[13]
Vahia V. Diagnostic and statistical manual of mental disorders 5: A quick glance. Indian J Psychiatry 2013; 55(3): 220-3.
[http://dx.doi.org/10.4103/0019-5545.117131] [PMID: 24082241]
[14]
Falkmer T, Anderson K, Falkmer M, Horlin C. Diagnostic procedures in autism spectrum disorders: A systematic literature review. Eur Child Adolesc Psychiatry 2013; 22(6): 329-40.
[http://dx.doi.org/10.1007/s00787-013-0375-0] [PMID: 23322184]
[15]
Maljaars J, Noens I, Scholte E, van Berckelaer-Onnes I. Evaluation of the criterion and convergent validity of the Diagnostic Interview for Social and Communication Disorders in young and low-functioning children. Autism 2012; 16(5): 487-97.
[http://dx.doi.org/10.1177/1362361311402857] [PMID: 21690082]
[16]
Skuse D, Warrington R, Bishop D, et al. The developmental, dimensional and diagnostic interview (3di): A novel computerized assessment for autism spectrum disorders. J Am Acad Child Adolesc Psychiatry 2004; 43(5): 548-58.
[http://dx.doi.org/10.1097/00004583-200405000-00008] [PMID: 15100561]
[17]
Erkan U, Thanh NHD. Autism spectrum disorder detection with machine learning methods. Curr Psy Res Rev 2019; 15(4): 297-308.
[http://dx.doi.org/10.2174/2666082215666191111121115]
[18]
Gepner B, Féron F. Autism: A world changing too fast for a mis-wired brain? Neurosci Biobehav Rev 2009; 33(8): 1227-42.
[http://dx.doi.org/10.1016/j.neubiorev.2009.06.006] [PMID: 19559043]
[19]
Moore SJ, Turnpenny P, Quinn A, et al. A clinical study of 57 children with fetal anticonvulsant syndromes. J Med Genet 2000; 37(7): 489-97.
[http://dx.doi.org/10.1136/jmg.37.7.489] [PMID: 10882750]
[20]
Miller MT, Strömland K, Ventura L, Johansson M, Bandim JM, Gillberg C. Autism associated with conditions characterized by developmental errors in early embryogenesis: A mini review. Int J Dev Neurosci 2005; 23(2-3): 201-19.
[http://dx.doi.org/10.1016/j.ijdevneu.2004.06.007] [PMID: 15749246]
[21]
Malkova NV, Yu CZ, Hsiao EY, Moore MJ, Patterson PH. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav Immun 2012; 26(4): 607-16.
[http://dx.doi.org/10.1016/j.bbi.2012.01.011] [PMID: 22310922]
[22]
Mazina V, Gerdts J, Trinh S, et al. Epigenetics of autism-related impairment: Copy number variation and maternal infection. J Dev Behav Pediatr 2015; 36(2): 61-7.
[http://dx.doi.org/10.1097/DBP.0000000000000126] [PMID: 25629966]
[23]
Lee BK, Magnusson C, Gardner RM, et al. Maternal hospitalization with infection during pregnancy and risk of autism spectrum disorders. Brain Behav Immun 2015; 44: 100-5.
[http://dx.doi.org/10.1016/j.bbi.2014.09.001] [PMID: 25218900]
[24]
Zerbo O, Iosif AM, Walker C, Ozonoff S, Hansen RL, Hertz-Picciotto I. Is maternal influenza or fever during pregnancy associated with autism or developmental delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) study. J Autism Dev Disord 2013; 43(1): 25-33.
[http://dx.doi.org/10.1007/s10803-012-1540-x] [PMID: 22562209]
[25]
Yamashita Y, Fujimoto C, Nakajima E, Isagai T, Matsuishi T. Possible association between congenital cytomegalovirus infection and autistic disorder. J Autism Dev Disord 2003; 33(4): 455-9.
[http://dx.doi.org/10.1023/A:1025023131029] [PMID: 12959425]
[26]
Shelton JF, Geraghty EM, Tancredi DJ, et al. Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides: the CHARGE study. Environ Health Perspect 2014; 122(10): 1103-9.
[http://dx.doi.org/10.1289/ehp.1307044] [PMID: 24954055]
[27]
Kumar RA, Christian SL. Genetics of autism spectrum disorders. Curr Neurol Neurosci Rep 2009; 9(3): 188-97.
[http://dx.doi.org/10.1007/s11910-009-0029-2] [PMID: 19348707]
[28]
Spooren W, Lindemann L, Ghosh A, Santarelli L. Synapse dysfunction in autism: A molecular medicine approach to drug discovery in neurodevelopmental disorders. Trends Pharmacol Sci 2012; 33(12): 669-84.
[http://dx.doi.org/10.1016/j.tips.2012.09.004] [PMID: 23084458]
[29]
Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 1999; 23(2): 185-8.
[http://dx.doi.org/10.1038/13810] [PMID: 10508514]
[30]
Jiang YH, Sahoo T, Michaelis RC, et al. A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. Am J Med Genet A 2004; 131(1): 1-10.
[PMID: 15389703]
[31]
Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 2011; 25(1): 40-5.
[http://dx.doi.org/10.1016/j.bbi.2010.08.003] [PMID: 20705131]
[32]
Madore C, Leyrolle Q, Lacabanne C, et al. Neuroinflammation in Autism: Plausible role of maternal inflammation, dietary omega 3, and microbiota. Neural Plast 2016; 2016: 1-15.
[http://dx.doi.org/10.1155/2016/3597209] [PMID: 27840741]
[33]
James SJ, Melnyk S, Jernigan S, et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet 2006; 141B(8): 947-56.
[http://dx.doi.org/10.1002/ajmg.b.30366] [PMID: 16917939]
[34]
James SJ, Cutler P, Melnyk S, et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr 2004; 80(6): 1611-7.
[http://dx.doi.org/10.1093/ajcn/80.6.1611] [PMID: 15585776]
[35]
Rose S, Melnyk S, Pavliv O, et al. Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Transl Psychiatry 2012; 2(7): e134.
[http://dx.doi.org/10.1038/tp.2012.61] [PMID: 22781167]
[36]
Rose S, Melnyk S, Trusty TA, et al. Intracellular and extracellular redox status and free radical generation in primary immune cells from children with autism. Autism Res Treat 2012; 2012: 1-10.
[http://dx.doi.org/10.1155/2012/986519] [PMID: 22928106]
[37]
James SJ, Melnyk S, Fuchs G, et al. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr 2009; 89(1): 425-30.
[http://dx.doi.org/10.3945/ajcn.2008.26615] [PMID: 19056591]
[38]
James SJ, Rose S, Melnyk S, et al. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J 2009; 23(8): 2374-83.
[http://dx.doi.org/10.1096/fj.08-128926] [PMID: 19307255]
[39]
Ghezzo A, Visconti P, Abruzzo PM, et al. Oxidative stress and erythrocyte membrane alterations in children with Autism: Correlation with clinical features. PLoS One 2013; 8(6): e66418.
[http://dx.doi.org/10.1371/journal.pone.0066418] [PMID: 23840462]
[40]
Söğüt S, Zoroğlu SS, Özyurt H, et al. Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism. Clin Chim Acta 2003; 331(1-2): 111-7.
[http://dx.doi.org/10.1016/S0009-8981(03)00119-0] [PMID: 12691871]
[41]
Zoroglu SS, Armutcu F, Ozen S, et al. Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism. Eur Arch Psychiatry Clin Neurosci 2004; 254(3): 143-7.
[http://dx.doi.org/10.1007/s00406-004-0456-7] [PMID: 15205966]
[42]
Chauhan A, Chauhan V, Brown WT, Cohen I. Oxidative stress in autism: Increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin - the antioxidant proteins. Life Sci 2004; 75(21): 2539-49.
[http://dx.doi.org/10.1016/j.lfs.2004.04.038] [PMID: 15363659]
[43]
Damodaran LPM, Arumugam G. Urinary oxidative stress markers in children with autism. Redox Rep 2011; 16(5): 216-22.
[http://dx.doi.org/10.1179/1351000211Y.0000000012] [PMID: 22005342]
[44]
Napoli E, Wong S, Giulivi C. Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism. Mol Autism 2013; 4(1): 2.
[http://dx.doi.org/10.1186/2040-2392-4-2] [PMID: 23347615]
[45]
Frye RE, Melnyk S, MacFabe DF. Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Transl Psychiatry 2013; 3(1): e220.
[http://dx.doi.org/10.1038/tp.2012.143] [PMID: 23340503]
[46]
Tang G, Gudsnuk K, Kuo SH, et al. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron 2014; 83(5): 1131-43.
[http://dx.doi.org/10.1016/j.neuron.2014.07.040] [PMID: 25155956]
[47]
Piochon C, Kloth AD, Grasselli G, et al. Erratum: Corrigendum: Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism. Nat Commun 2015; 6(1): 6014.
[http://dx.doi.org/10.1038/ncomms7014] [PMID: 25625889]
[48]
Kim H-J, Cho M-H, Shim WH, et al. Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects. Mol Psychiatry 2017; 22(11): 1576-84.
[http://dx.doi.org/10.1038/mp.2016.103] [PMID: 27400854]
[49]
Hansel C. Deregulation of synaptic plasticity in autism. Neurosci Lett 2019; 688: 58-61.
[http://dx.doi.org/10.1016/j.neulet.2018.02.003] [PMID: 29421544]
[50]
Fattorusso A, Di Genova L, Dell’Isola G, Mencaroni E, Esposito S. Autism spectrum disorders and the gut microbiota. Nutrients 2019; 11(3): 521.
[http://dx.doi.org/10.3390/nu11030521] [PMID: 30823414]
[51]
Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ 2014; 63(2): 1-21.
[PMID: 24670961]
[52]
Buescher AVS, Cidav Z, Knapp M, Mandell DS. Costs of autism spectrum disorders in the United Kingdom and the United States. JAMA Pediatr 2014; 168(8): 721-8.
[http://dx.doi.org/10.1001/jamapediatrics.2014.210] [PMID: 24911948]
[53]
Kapp SK, Gillespie-Lynch K, Sherman LE, Hutman T. Deficit, difference, or both? Autism and neurodiversity. Dev Psychol 2013; 49(1): 59-71.
[http://dx.doi.org/10.1037/a0028353] [PMID: 22545843]
[54]
Modahl C, Green LA, Fein D, et al. Plasma oxytocin levels in autistic children. Biol Psychiatry 1998; 43(4): 270-7.
[http://dx.doi.org/10.1016/S0006-3223(97)00439-3] [PMID: 9513736]
[55]
Stokstad E. Development. New hints into the biological basis of autism. Science 2001; 294(5540): 34-7.
[http://dx.doi.org/10.1126/science.294.5540.34] [PMID: 11588233]
[56]
Ji NY, Findling RL. An update on pharmacotherapy for autism spectrum disorder in children and adolescents. Curr Opin Psychiatry 2015; 28(2): 91-101.
[http://dx.doi.org/10.1097/YCO.0000000000000132] [PMID: 25602248]
[57]
Green VA, Pituch KA, Itchon J, Choi A, O’Reilly M, Sigafoos J. Internet survey of treatments used by parents of children with autism. Res Dev Disabil 2006; 27(1): 70-84.
[http://dx.doi.org/10.1016/j.ridd.2004.12.002] [PMID: 15919178]
[58]
Perrin JM, Coury DL, Hyman SL, Cole L, Reynolds AM, Clemons T. Complementary and alternative medicine use in a large pediatric autism sample. Pediatrics 2012; 130 (Suppl. 2): S77-82.
[http://dx.doi.org/10.1542/peds.2012-0900E] [PMID: 23118257]
[59]
Brondino N, Fusar-Poli L, Rocchetti M, Provenzani U, Barale F, Politi P. Complementary and alternative therapies for autism spectrum disorder. Evid Based Complement Alternat Med 2015; 2015: 1-31.
[http://dx.doi.org/10.1155/2015/258589] [PMID: 26064157]
[60]
Brian Dennis, Carpenter MH, Greenberg AL. Teaching socially expressive behaviors to children with autism through video modeling. Educ Treat Child 2010; 33(3): 371-93.
[http://dx.doi.org/10.1353/etc.0.0104]
[61]
Charlop-Christy MH, Le L, Freeman KA. A comparison of video modeling with in vivo modeling for teaching children with autism. J Autism Dev Disord 2000; 30(6): 537-52.
[http://dx.doi.org/10.1023/A:1005635326276] [PMID: 11261466]
[62]
Miltenberger CA, Charlop MH. The comparative effectiveness of portable video modelling vs. traditional video modelling interventions with children with autism spectrum disorders. J Dev Phys Disabil 2015; 27(3): 341-58.
[http://dx.doi.org/10.1007/s10882-014-9416-y]
[63]
Kimberly Sancho, Reeve SA, Sidener DW. Two variations of video modelling interventions for teaching play skills to children with autism. Educ Treat Child 2010; 33(3): 421-42.
[http://dx.doi.org/10.1353/etc.0.0097]
[64]
Plavnick JB, Vitale FA. A comparison of vocal mind training strategies for children with autism spectrum disorders. J Posit Behav Interv 2016; 18(1): 52-62.
[http://dx.doi.org/10.1177/1098300714548800]
[65]
Cihak DF, Smith CC, Cornett A, Coleman MB. The use of video modelling with the picture exchange communication system to increase independent communicative initiations in preschoolers with autism and developmental delays. Focus Autism Other Dev Disabl 2012; 27(1): 3-11.
[http://dx.doi.org/10.1177/1088357611428426]
[66]
Macpherson K, Charlop MH, Miltenberger CA. Using portable video modeling technology to increase the compliment behaviors of children with autism during athletic group play. J Autism Dev Disord 2015; 45(12): 3836-45.
[http://dx.doi.org/10.1007/s10803-014-2072-3] [PMID: 24573335]
[67]
D’Ateno P, Mangiapanello K, Taylor BA. Using video modelling to teach complex play sequences to a preschooler with autism. J Posit Behav Interv 2003; 5(1): 5-11.
[http://dx.doi.org/10.1177/10983007030050010801]
[68]
MacDonald RCM, Garrigan E, Vangala M. Using video modelling to teach pretend play to children with autism. Behav Interv 2005; 20(4): 225-38.
[http://dx.doi.org/10.1002/bin.197]
[69]
MacManus C, MacDonald R, Ahearn WH. Teaching and generalizing pretend play in children with autism using video modelling and matrix training. Behav Interv 2015; 30(3): 191-218.
[http://dx.doi.org/10.1002/bin.1406]
[70]
Palechka G, MacDonald R. A comparison of the acquisition of play skills using instructor-created video models and commercially available videos. Educ Treat Child 2010; 33(3): 457-74.
[http://dx.doi.org/10.1353/etc.0.0100]
[71]
MacDonald R, Sacramone S, Mansfield R, Wiltz K, Ahearn WH. Using video modeling to teach reciprocal pretend play to children with autism. J Appl Behav Anal 2009; 42(1): 43-55.
[http://dx.doi.org/10.1901/jaba.2009.42-43] [PMID: 19721729]
[72]
Maione L, Mirenda P. Effects of video modelling and video feedback on peer-directed social language skills of a child with autism. J Posit Behav Interv 2006; 8(2): 106-18.
[http://dx.doi.org/10.1177/10983007060080020201]
[73]
Reagon KAHT, Endicott K. Teaching pretend play skills to a child with autism using video modelling with a sibling as a model and play partner. Educ Treat Child 2006; 29: 517-28.
[74]
Stokes TF, Baer DM. An implicit technology of generalization1. J Appl Behav Anal 1977; 10(2): 349-67.
[http://dx.doi.org/10.1901/jaba.1977.10-349] [PMID: 16795561]
[75]
Rex C, Charlop MH, Spector V. Using video modeling as an anti-bullying intervention for children with autism spectrum disorder. J Autism Dev Disord 2018; 48(8): 2701-13.
[http://dx.doi.org/10.1007/s10803-018-3527-8] [PMID: 29516338]
[76]
Dueñas AD, Plavnick JB, Bak MYS. Effects of joint video modeling on unscripted play behavior of children with autism spectrum disorder. J Autism Dev Disord 2019; 49(1): 236-47.
[http://dx.doi.org/10.1007/s10803-018-3719-2] [PMID: 30136112]
[77]
Kuriakose S, Lahiri U. Design of a physiology-sensitive vr-based social communication platform for children with autism. IEEE Trans Neural Syst Rehabil Eng 2017; 25(8): 1180-91.
[http://dx.doi.org/10.1109/TNSRE.2016.2613879] [PMID: 28114071]
[78]
Kool R, Lawver T. Play therapy: Considerations and applications for the practitioner. Psychiatry 2010; 7(10): 19-24.
[PMID: 21103141]
[79]
Mulherin MA. The Masterson Approach with play therapy: A parallel process between mother and child. Am J Psychother 2001; 55(2): 251-72.
[http://dx.doi.org/10.1176/appi.psychotherapy.2001.55.2.251] [PMID: 11467260]
[80]
O’Connor K. The value and use of interpretation in play therapy. Prof Psychol Res Pr 2002; 33(6): 523-8.
[http://dx.doi.org/10.1037/0735-7028.33.6.523]
[81]
Russell RLSS. Child Psychotherapy Process Research. Boston: Springer 1998.
[http://dx.doi.org/10.1007/978-1-4757-9038-2_3]
[82]
Landreth GL. Therapeutic limit setting in the play therapy relationship. Prof Psychol Res Pr 2002; 33(6): 529-35.
[http://dx.doi.org/10.1037/0735-7028.33.6.529]
[83]
Group psychotherapy with children. The theory and practice of play therapy. Northvale: Aronson 1994.
[84]
Landreth GSD. Child-centered play therapy. New York: Wiley 1997.
[85]
Children in play therapy: a key to understanding normal and disturbed emotions. New York: McGraw-Hill Book Company Inc. 1953.
[86]
Music Therapy for the Autistic Child. United Kingdom: Oxford University Press 1978.
[87]
Forms of vitality. Exploring dynamic experience in psychology and the arts. United Kingdom: Oxford University Press 2010.
[88]
Malloch STC. Communicative Musicality. United Kingdom: Oxford University Press 2008.
[89]
Geretsegger M, Holck U, Carpente JA, Elefant C, Kim J, Gold C. Common characteristics of improvisational approaches in music therapy for children with autism spectrum disorder: Developing treatment guidelines. J Music Ther 2015; 52(2): 258-81.
[http://dx.doi.org/10.1093/jmt/thv005] [PMID: 26019303]
[90]
Geretsegger M, Elefant C, Mössler KA, Gold C. Music therapy for people with autism spectrum disorder. Cochrane Libr 2014; 2016(3): CD004381.
[http://dx.doi.org/10.1002/14651858.CD004381.pub3] [PMID: 24936966]
[91]
Reschke-Hernández AE. History of music therapy treatment interventions for children with autism. J Music Ther 2011; 48(2): 169-207.
[http://dx.doi.org/10.1093/jmt/48.2.169] [PMID: 21938891]
[92]
Intuitive parenting: A hidden source of musical stimulation in infancy. Musical beginnings: Origins and development of musical competence. New York: Oxford University Press 1996; p. 88.
[93]
Stern DNHL, Haft W, Dore J. Affect attunement: The sharing of feeling states between mother and infant by means of inter-modal fluency. Norwood: Ablex Publishing Corporation 1985.
[94]
Music in everyday life. Cambridge: Cambridge University Press 2000.
[95]
Song lyrics and the alteration of self-image. J Music Ther 2011; 20(3): 225-41.
[96]
Batt-Rawden KB, DeNora T, Ruud E. Music listening and empowerment in health promotion: A study of the role and significance of music in everyday life of the long-term ill. Nord J Music Ther 2005; 14(2): 120-36.
[http://dx.doi.org/10.1080/08098130509478134]
[97]
Cuypers K, Krokstad S, Lingaas Holmen T, Skjei Knudtsen M, Bygren LO, Holmen J. Patterns of receptive and creative cultural activities and their association with perceived health, anxiety, depression and satisfaction with life among adults: The HUNT study, Norway. J Epidemiol Community Health 2012; 66(8): 698-703.
[http://dx.doi.org/10.1136/jech.2010.113571] [PMID: 21609946]
[98]
Giese T. Complementary and alternative medicine (CAM) position paper. Am J Occup Ther 2005; 59(6): 653-5.
[http://dx.doi.org/10.5014/ajot.59.6.653] [PMID: 16363186]
[99]
Field T. Yoga clinical research review. Complement Ther Clin Pract 2011; 17(1): 1-8.
[http://dx.doi.org/10.1016/j.ctcp.2010.09.007] [PMID: 21168106]
[100]
Krisanaprakornkit T, Krisanaprakornkit W, Piyavhatkul N, Laopaiboon M. Meditation therapy for anxiety disorders. Cochrane Database Syst Rev 2006; (1): CD004998.
[PMID: 16437509]
[101]
Lin KY, Hu YT, Chang KJ, Lin HF, Tsauo JY. Effects of yoga on psychological health, quality of life, and physical health of patients with cancer: A meta-analysis. Evid Based Complement Alternat Med 2011; 2011: 1-12.
[http://dx.doi.org/10.1155/2011/659876] [PMID: 21437197]
[102]
Sarris J, Camfield D, Berk M. Complementary medicine, self-help, and lifestyle interventions for Obsessive Compulsive Disorder (OCD) and the OCD spectrum: A systematic review. J Affect Disord 2012; 138(3): 213-21.
[http://dx.doi.org/10.1016/j.jad.2011.04.051] [PMID: 21620478]
[103]
Vancampfort D, De Hert M, Knapen J, et al. State anxiety, psychological stress and positive well-being responses to yoga and aerobic exercise in people with schizophrenia: A pilot study. Disabil Rehabil 2011; 33(8): 684-9.
[http://dx.doi.org/10.3109/09638288.2010.509458] [PMID: 20718623]
[104]
Chong CS, Tsunaka M, Tsang HW, Chan EP, Cheung WM. Effects of yoga on stress management in healthy adults: A systematic review. Altern Ther Health Med 2011; 17(1): 32-8.
[PMID: 21614942]
[105]
Ehleringer J. Yoga for children on the autism spectrum. Int J Yoga Therap 2010; 20(1): 131-9.
[http://dx.doi.org/10.17761/ijyt.20.1.eu176u2721423510]
[106]
Galantino ML, Galbavy R, Quinn L. Therapeutic effects of yoga for children: A systematic review of the literature. Pediatr Phys Ther 2008; 20(1): 66-80.
[http://dx.doi.org/10.1097/PEP.0b013e31815f1208] [PMID: 18300936]
[107]
Harrison LJ, Manocha R, Rubia K. Sahaja yoga meditation as a family treatment programme for children with attention deficit-hyperactivity disorder. Clin Child Psychol Psychiatry 2004; 9(4): 479-97.
[http://dx.doi.org/10.1177/1359104504046155]
[108]
Kenny M. Integrated movement therapy: Yoga-based therapy as a viable and effective intervention for autism spectrum and related disorders. Int J Yoga Therap 2002; 12(1): 71-9.
[http://dx.doi.org/10.17761/ijyt.12.1.r978vxt214683904]
[109]
Klatt M. Integrating yoga, meditation, and occupational therapy for inner-city children. Explore 2009; 5(3): 152-3.
[http://dx.doi.org/10.1016/j.explore.2009.03.026]
[110]
Peck HL, Kehle TJ, Bray MA, Theodore LA. Yoga as an intervention for children with attention problems. School Psych Rev 2005; 34(3): 415-24.
[http://dx.doi.org/10.1080/02796015.2005.12086295]
[111]
Uma K, Nagendra HR, Nagarathna R, Vaidehi S, Seethalakshmi R. The integrated approach of yoga: A therapeutic tool for mentally retarded children: A one-year controlled study. J Intellect Disabil Res 1989; 33(5): 415-21.
[http://dx.doi.org/10.1111/j.1365-2788.1989.tb01496.x] [PMID: 2795647]
[112]
Gwynette MF, Warren NJ. Yoga as an intervention for patients with autism spectrum disorder: A review of the evidence and future directions. Autism Open Access 2015; 5(3)
[http://dx.doi.org/10.4172/2165-7890.1000155]
[113]
Sotoodeh MS, Arabameri E, Panahibakhsh M, Kheiroddin F, Mirdoozandeh H, Ghanizadeh A. Effectiveness of yoga training program on the severity of autism. Complement Ther Clin Pract 2017; 28: 47-53.
[http://dx.doi.org/10.1016/j.ctcp.2017.05.001] [PMID: 28779937]
[114]
Tanksale R, Sofronoff K, Sheffield J, Gilmour J. Evaluating the effects of a yoga-based program integrated with third-wave cognitive behavioral therapy components on self-regulation in children on the autism spectrum: A pilot randomized controlled trial. Autism 2021; 25(4): 995-1008.
[http://dx.doi.org/10.1177/1362361320974841] [PMID: 33238718]
[115]
Wong C, Odom SL, Hume KA, et al. Evidence-based practices for children, youth, and young adults with autism spectrum disorder: A comprehensive review. J Autism Dev Disord 2015; 45(7): 1951-66.
[http://dx.doi.org/10.1007/s10803-014-2351-z] [PMID: 25578338]
[116]
Kwon K, Kim E, Sheridan S. Behavioral competence and academic functioning among early elementary children with externalizing problems. School Psych Rev 2012; 41(2): 123-40.
[http://dx.doi.org/10.1080/02796015.2012.12087516]
[117]
Radley KC, Jenson WR, Clark E, O’Neill RE. The feasibility and effects of a parent-facilitated social skills training program on social engagement of children with autism spectrum disorders. Psychol Sch 2014; 51(3): 241-55.
[http://dx.doi.org/10.1002/pits.21749]
[118]
Usher LV, Burrows CA, Schwartz CB, Henderson HA. Social competence with an unfamiliar peer in children and adolescents with high functioning autism: Measurement and individual differences. Res Autism Spectr Disord 2015; 17: 25-39.
[http://dx.doi.org/10.1016/j.rasd.2015.05.005] [PMID: 26161136]
[119]
Chester M, Richdale AL, McGillivray J. Group-based social skills training with play for children on the autism spectrum. J Autism Dev Disord 2019; 49(6): 2231-42.
[http://dx.doi.org/10.1007/s10803-019-03892-7] [PMID: 30701435]
[120]
Chang YS, Owen JP, Desai SS, et al. Autism and sensory processing disorders: Shared white matter disruption in sensory pathways but divergent connectivity in social-emotional pathways. PLoS One 2014; 9(7): e103038.
[http://dx.doi.org/10.1371/journal.pone.0103038] [PMID: 25075609]
[121]
Leekam SR, Nieto C, Libby SJ, Wing L, Gould J. Describing the sensory abnormalities of children and adults with autism. J Autism Dev Disord 2007; 37(5): 894-910.
[http://dx.doi.org/10.1007/s10803-006-0218-7] [PMID: 17016677]
[122]
Tomchek SD, Dunn W. Sensory processing in children with and without autism: A comparative study using the short sensory profile. Am J Occup Ther 2007; 61(2): 190-200.
[http://dx.doi.org/10.5014/ajot.61.2.190] [PMID: 17436841]
[123]
Baranek GT. Efficacy of sensory and motor interventions for children with autism. J Autism Dev Disord 2002; 32(5): 397-422.
[http://dx.doi.org/10.1023/A:1020541906063] [PMID: 12463517]
[124]
Pengelly S, Rogers P, Evans K. Space at home for families with a child with autistic spectrum disorder. Br J Occup Ther 2009; 72(9): 378-83.
[http://dx.doi.org/10.1177/030802260907200902]
[125]
Hoefman R, Payakachat N, van Exel J, et al. Caring for a child with autism spectrum disorder and parents’ quality of life: Application of the CarerQol. J Autism Dev Disord 2014; 44(8): 1933-45.
[http://dx.doi.org/10.1007/s10803-014-2066-1] [PMID: 24577786]
[126]
Case-Smith J, Weaver LL, Fristad MA. A systematic review of sensory processing interventions for children with autism spectrum disorders. Autism 2015; 19(2): 133-48.
[http://dx.doi.org/10.1177/1362361313517762] [PMID: 24477447]
[127]
Schaaf RCMZ. Clinician’s guide for implementing Ayres Sensory Integration®: promoting participation for children with autism. Bethesda: American Occupational Therapy Association 2015.
[128]
Schaaf RC, Benevides TW, Kelly D, Mailloux-Maggio Z. Occupational therapy and sensory integration for children with autism: A feasibility, safety, acceptability and fidelity study. Autism 2012; 16(3): 321-7.
[http://dx.doi.org/10.1177/1362361311435157] [PMID: 22318118]
[129]
Schaaf RC, Leiby B, Benevides T, et al. An intervention for sensory difficulties in children with autism: A randomized trial. J Autism Dev Disord 2014; 44(6): 1489-91.
[http://dx.doi.org/10.1007/s10803-014-2111-0] [PMID: 24214165]
[130]
Pfeiffer BA, Koenig K, Kinnealey M, Sheppard M, Henderson L. Effectiveness of sensory integration interventions in children with autism spectrum disorders: A pilot study. Am J Occup Ther 2011; 65(1): 76-85.
[http://dx.doi.org/10.5014/ajot.2011.09205] [PMID: 21309374]
[131]
Randell E, McNamara R, Delport S, et al. Sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children: Study protocol for a pragmatic randomised controlled trial. Trials 2019; 20(1): 113.
[http://dx.doi.org/10.1186/s13063-019-3205-y] [PMID: 30744672]
[132]
Warren LR, Rao PA, Paton DC. A pilot observational study of an acupressure/acupuncture intervention in children with autism spectrum disorder. J Altern Complement Med 2017; 23(11): 844-51.
[http://dx.doi.org/10.1089/acm.2016.0257] [PMID: 28530441]
[133]
Wong VCNCV, Cheuk DKL. Acupuncture in autism spectrum disorders. New York: Springer Science & Media 2014.
[134]
Chen WX, Wu-Li L, Wong VCN. Electroacupuncture for children with autism spectrum disorder: Pilot study of 2 cases. J Altern Complement Med 2008; 14(8): 1057-65.
[http://dx.doi.org/10.1089/acm.2007.0823] [PMID: 18990052]
[135]
Wong VCN, Sun JG. Randomized controlled trial of acupuncture versus sham acupuncture in autism spectrum disorder. J Altern Complement Med 2010; 16(5): 545-53.
[http://dx.doi.org/10.1089/acm.2007.0768] [PMID: 20804366]
[136]
Allam H, Eldine NG, Helmy G. Scalp acupuncture effect on language development in children with autism: A pilot study. J Altern Complement Med 2008; 14(2): 109-14.
[http://dx.doi.org/10.1089/acm.2007.0508] [PMID: 18315511]
[137]
Chan AS, Cheung MC, Sze SL, Leung WW. Seven-star needle stimulation improves language and social interaction of children with autistic spectrum disorders. Am J Chin Med 2009; 37(3): 495-504.
[http://dx.doi.org/10.1142/S0192415X09007004] [PMID: 19606510]
[138]
Yau CH, Ip CL, Chau YY. The therapeutic effect of scalp acupuncture on natal autism and regressive autism. Chin Med 2018; 13(1): 30.
[http://dx.doi.org/10.1186/s13020-018-0189-6] [PMID: 29983730]
[139]
Jin BX, Li N, Zhao Y, Qian XG, Liu ZH, Yang Y, et al. Effect of acupoint catgut embedding therapy on joint attention and social communication in children with autism spectrum disorder: a randomized controlled trial. Zhongguo Zhenjiu 2020; 40(2): 162-6.
[140]
Zhang JS, Zhang XT, Zou LP, Zhang R, Han SP, Han JS. A preliminary study on effect of transcutaneous electrical acupoint stimulation for children with Autism. Zhen Ci Yan Jiu 2017; 42(3): 249-53.
[PMID: 29071983]
[141]
Kingsnorth S, Blain S, McKeever P. Physiological and emotional responses of disabled children to therapeutic clowns: A pilot study. Evid Based Complement Alternat Med 2011; 2011: 1-10.
[http://dx.doi.org/10.1093/ecam/neq008] [PMID: 21799690]
[142]
Golan G, Tighe P, Dobija N, Perel A, Keidan I. Clowns for the prevention of preoperative anxiety in children: A randomized controlled trial. Paediatr Anaesth 2009; 19(3): 262-6.
[http://dx.doi.org/10.1111/j.1460-9592.2008.02903.x] [PMID: 19143948]
[143]
Meiri N, Ankri A, Ziadan F, et al. Assistance of medical clowns improves the physical examinations of children aged 2-6 years. Isr Med Assoc J 2017; 19(12): 786-91.
[PMID: 29235739]
[144]
Sridharan K, Sivaramakrishnan G. Therapeutic clowns in pediatrics: A systematic review and meta-analysis of randomized controlled trials. Eur J Pediatr 2016; 175(10): 1353-60.
[http://dx.doi.org/10.1007/s00431-016-2764-0] [PMID: 27605131]
[145]
Ben-Pazi H, Cohen A, Kroyzer N, et al. Clown-care reduces pain in children with cerebral palsy undergoing recurrent botulinum toxin injections- A quasi-randomized controlled crossover study. PLoS One 2017; 12(4): e0175028.
[http://dx.doi.org/10.1371/journal.pone.0175028] [PMID: 28414728]
[146]
Hansen LK, Kibaek M, Martinussen T, Kragh L, Hejl M. Effect of a clown’s presence at botulinum toxin injections in children: A randomized, prospective study. J Pain Res 2011; 4: 297-300.
[http://dx.doi.org/10.2147/JPR.S23199] [PMID: 22003302]
[147]
van Venrooij LT, Barnhoorn PC. Hospital clowning: A paediatrician’s view. Eur J Pediatr 2017; 176(2): 191-7.
[http://dx.doi.org/10.1007/s00431-016-2821-8] [PMID: 28013377]
[148]
Feniger-schaal RCA, Mittlelberg E, Ben EY. Intervention of medical (therapeutic) clowns in a kindergarten for children with intellectual disability: A case study intervention of medical (therapeutic) clowns in a kindergarten for children with intellectual disability: A case study. Int J Disabil Dev Educ 2018; 1-13.
[149]
Shefer S, Leon Attia O, Rosenan R, Wald OA, Ende H, Gabis LV. Benefits of medical clowning in the treatment of young children with autism spectrum disorder. Eur J Pediatr 2019; 178(8): 1283-9.
[http://dx.doi.org/10.1007/s00431-019-03415-7] [PMID: 31243575]
[150]
Jau J, Hodgson D. How interaction with animals can benefit mental health: A phenomenological study. Soc Work Ment Health 2018; 16(1): 20-33.
[http://dx.doi.org/10.1080/15332985.2017.1302037]
[151]
O’Haire ME, McKenzie SJ, Beck AM, Slaughter V. Social behaviors increase in children with autism in the presence of animals compared to toys. PLoS One 2013; 8(2): e57010.
[http://dx.doi.org/10.1371/journal.pone.0057010] [PMID: 23468902]
[152]
Martin F, Farnum J. Animal-assisted therapy for children with pervasive developmental disorders. West J Nurs Res 2002; 24(6): 657-70.
[http://dx.doi.org/10.1177/019394502320555403] [PMID: 12365766]
[153]
Solomon O. What a dog can do: Children with autism and therapy dogs in social interaction. Ethos 2010; 38: 143-66.
[http://dx.doi.org/10.1111/j.1548-1352.2010.01085.x]
[154]
Nagengast SL, Baun MM, Megel M, Michael Leibowitz JM. The effects of the presence of a companion animal on physiological arousal and behavioral distress in children during a physical examination. J Pediatr Nurs 1997; 12(6): 323-30.
[http://dx.doi.org/10.1016/S0882-5963(97)80058-9] [PMID: 9420370]
[155]
Smith BP, Dale AA. Integrating animals in the classroom: The attitudes and experiences of Australian school teachers toward animal-assisted interventions for children with Autism Spectrum Disorder. Pet Behav Sci 2016; 1(1): 13-22.
[http://dx.doi.org/10.21071/pbs.v0i1.3994]
[156]
Michelotto ALL, Anater A, Guebert MCC, Borges TD, Michelotto PV Jr, Pimpão CT. Animal-assisted activity for children with autism spectrum disorder: Parents’ and therapists’ perception. J Altern Complement Med 2019; 25(9): 928-9.
[http://dx.doi.org/10.1089/acm.2019.0196] [PMID: 31328957]
[157]
Masini E, Loi E, Vega-Benedetti AF, et al. An overview of the main genetic, epigenetic and environmental factors involved in autism spectrum disorder focusing on synaptic activity. Int J Mol Sci 2020; 21(21): 8290.
[http://dx.doi.org/10.3390/ijms21218290] [PMID: 33167418]
[158]
South M, Rodgers J, Van Hecke A. Anxiety and ASD: Current progress and ongoing challenges. J Autism Dev Disord 2017; 47(12): 3679-81.
[http://dx.doi.org/10.1007/s10803-017-3322-y] [PMID: 28988366]
[159]
Lyall K, Croen L, Daniels J, et al. The changing epidemiology of autism spectrum disorders. Annu Rev Public Health 2017; 38(1): 81-102.
[http://dx.doi.org/10.1146/annurev-publhealth-031816-044318] [PMID: 28068486]
[160]
Will MN, Currans K, Smith J, et al. Evidenced-based interventions for children with autism spectrum disorder. Curr Probl Pediatr Adolesc Health Care 2018; 48(10): 234-49.
[http://dx.doi.org/10.1016/j.cppeds.2018.08.014] [PMID: 30337149]
[161]
Mohammadi MR, Yadegari N, Hassanzadeh E, et al. Double-blind, placebo-controlled trial of risperidone plus amantadine in children with autism: A 10-week randomized study. Clin Neuropharmacol 2013; 36(6): 179-84.
[http://dx.doi.org/10.1097/WNF.0b013e3182a9339d] [PMID: 24201232]
[162]
Ishitobi M, Kosaka H, Takahashi T, et al. Effectiveness and tolerability of switching to aripiprazole from risperidone in subjects with autism spectrum disorders: A prospective open-label study. Clin Neuropharmacol 2013; 36(5): 151-6.
[http://dx.doi.org/10.1097/WNF.0b013e3182a31ec0] [PMID: 24045605]
[163]
Boon-yasidhi V, Jearnarongrit P, Tulayapichitchock P, Tarugsa J. Adverse effects of risperidone in children with autism spectrum disorders in a naturalistic clinical setting at siriraj hospital, Thailand. Psychiatry J 2014; 2014: 1-4.
[http://dx.doi.org/10.1155/2014/136158] [PMID: 24790986]
[164]
Tilmont Pittala E, Saint-Georges-Chaumet Y, Favrot C, Tanet A, Cohen D, Saint-Georges C. Clinical outcomes of interactive, intensive and individual (3i) play therapy for children with ASD: A two-year follow-up study. BMC Pediatr 2018; 18(1): 165.
[http://dx.doi.org/10.1186/s12887-018-1126-7] [PMID: 29753322]
[165]
Liu GH, Huang LS, Qian QF, Wang YX, Ge P. Curative effect of progressively integrated sandplay therapy on core symptoms and sleep management in preschool children with mild-to-moderate autism spectrum disorder. Zhongguo Dang Dai Er Ke Za Zhi 2019; 21(8): 743-8.
[PMID: 31416496]
[166]
Armstrong J, Girdler S, Davidson E, et al. Randomised controlled trial of a therapeutic playgroup for children with developmental delays. J Autism Dev Disord 2021; 51(4): 1039-53.
[http://dx.doi.org/10.1007/s10803-020-04580-7] [PMID: 32623539]
[167]
So WC, Cheng CH, Lam WY, et al. A robot-based play-drama intervention may improve the joint attention and functional play behaviors of Chinese-speaking preschoolers with autism spectrum disorder: A pilot study. J Autism Dev Disord 2020; 50(2): 467-81.
[http://dx.doi.org/10.1007/s10803-019-04270-z] [PMID: 31655965]
[168]
Chang YC, Shih W, Landa R, Kaiser A, Kasari C. Symbolic play in school-aged minimally verbal children with autism spectrum disorder. J Autism Dev Disord 2018; 48(5): 1436-45.
[http://dx.doi.org/10.1007/s10803-017-3388-6] [PMID: 29170936]
[169]
Bieleninik L, Geretsegger M, Mössler K, et al. Effects of improvisational music therapy vs enhanced standard care on symptom severity among children with autism spectrum disorder. JAMA 2017; 318(6): 525-35.
[http://dx.doi.org/10.1001/jama.2017.9478] [PMID: 28787504]
[170]
Gottfried T, Thompson G, Elefant C, Gold C. Reliability of the Music in Everyday Life (MEL) Scale: A parent-report assessment for children on the autism spectrum. J Music Ther 2018; 55(2): 133-55.
[http://dx.doi.org/10.1093/jmt/thy002] [PMID: 29800316]
[171]
Sharda M, Tuerk C, Chowdhury R, et al. Music improves social communication and auditory–motor connectivity in children with autism. Transl Psychiatry 2018; 8(1): 231.
[http://dx.doi.org/10.1038/s41398-018-0287-3] [PMID: 30352997]
[172]
Porter S, McConnell T, McLaughlin K, et al. Music therapy for children and adolescents with behavioural and emotional problems: A randomised controlled trial. J Child Psychol Psychiatry 2017; 58(5): 586-94.
[http://dx.doi.org/10.1111/jcpp.12656] [PMID: 27786359]
[173]
Crawford MJ, Gold C, Odell-Miller H, et al. International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: Time a study. Health Technol Assess 2017; 21(59): 1-40.
[http://dx.doi.org/10.3310/hta21590] [PMID: 29061222]
[174]
Cibrian FL, Madrigal M, Avelais M, Tentori M. Supporting coordination of children with ASD using neurological music therapy: A pilot randomized control trial comparing an elastic touch-display with tambourines. Res Dev Disabil 2020; 106: 103741.
[http://dx.doi.org/10.1016/j.ridd.2020.103741] [PMID: 32950853]
[175]
Corbett BA, Ioannou S, Key AP, et al. Treatment effects in social cognition and behavior following a theater-based intervention for youth with autism. Dev Neuropsychol 2019; 44(7): 481-94.
[http://dx.doi.org/10.1080/87565641.2019.1676244] [PMID: 31589087]
[176]
Sarabzadeh M, Azari BB, Helalizadeh M. The effect of six weeks of Tai Chi Chuan training on the motor skills of children with Autism Spectrum Disorder. J Bodyw Mov Ther 2019; 23(2): 284-90.
[http://dx.doi.org/10.1016/j.jbmt.2019.01.007] [PMID: 31103109]
[177]
Frazier TW, Krishna J, Klingemier E, Beukemann M, Nawabit R, Ibrahim S. A randomized, crossover trial of a novel sound-to-sleep mattress technology in children with autism and sleep difficulties. J Clin Sleep Med 2017; 13(1): 95-104.
[http://dx.doi.org/10.5664/jcsm.6398] [PMID: 27784416]
[178]
Direito B, Mouga S, Sayal A, et al. Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism. Autism 2021; 25(6): 1746-60.
[http://dx.doi.org/10.1177/13623613211002052] [PMID: 33765841]

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