Abstract
Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.
Keywords: Polyethylenimine, polymer, DNA, transfection, gene therapy, drug delivery, medicinal chemistry, biomedical applications
Current Medicinal Chemistry
Title: Polyethylenimine In Medicinal Chemistry
Volume: 15 Issue: 27
Author(s): Paola Vicennati, Antonella Giuliano, Giancarlo Ortaggi and Andrea Masotti
Affiliation:
Keywords: Polyethylenimine, polymer, DNA, transfection, gene therapy, drug delivery, medicinal chemistry, biomedical applications
Abstract: Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.
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Cite this article as:
Vicennati Paola, Giuliano Antonella, Ortaggi Giancarlo and Masotti Andrea, Polyethylenimine In Medicinal Chemistry, Current Medicinal Chemistry 2008; 15 (27) . https://dx.doi.org/10.2174/092986708786242778
DOI https://dx.doi.org/10.2174/092986708786242778 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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