Ball Milling in Organic Transformations

Keya      Roy; Suprakash      Sahoo; Anay      Saha; Laksmikanta      Adak

doi:10.2174/1385272827666221223143844

Abstract

In organic synthesis, mechanochemical approaches have received increased attention because of their broad applications in green methodologies. By utilization of mechanical forces on the various reactants, there is a certain increase of their surface area and also areas of contact, which usually make reaction pathways more available through a greater number of effective collisions. Mechanical energy can be produced and transferred through ball mills, one of the highest necessary devices for green organic solid-state reactions. In the last few decades, various challenging organic transformations have been published using ball milling in different fields of organic synthesis. Ball milling has received tremendous attention in numerous organic synthesis since it allows for reactions to occur at ambient temperature in the absence of any solvent under mild conditions which are compatible for a green process. The carbon-carbon and carbon–heteroatom bond formation reactions and also synthesis of heterocyclic compounds are of ample importance in both academia and pharmaceutical industry. This review will highlight the recent developments of amidation reactions, asymmetric synthesis, various heterocyclic compounds synthesis, crosscoupling reactions, C–H bond activation for C–C and carbon–heteroatom bond formation reactions under the ballmilling conditions.

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DOI https://dx.doi.org/10.2174/1385272827666221223143844	Print ISSN 1385-2728
Publisher Name Bentham Science Publisher	Online ISSN 1875-5348

Current Organic Chemistry

Ball Milling in Organic Transformations

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

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Ball Milling in Organic Transformations

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

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