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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Review Article

Novel Nanotechnological Strategies for Skin Anti-aging

Author(s): Sara Pozos-Nonato, Clara Luisa Domínguez-Delgado*, Kenia Areli Campos-Santander, Allyson Amelia Benavides, Sandy María Pacheco-Ortin, Rosa Isabel Higuera-Piedrahita, Guillermo Resendiz-González and Eva María Molina-Trinidad

Volume 24, Issue 11, 2023

Published on: 20 January, 2023

Page: [1397 - 1419] Pages: 23

DOI: 10.2174/1389201024666221223095315

Price: $65

Abstract

Background: Nanoparticle formulations development for anti-aging treatment is increasing due to their multifunctional properties. These nanotechnological strategies can target cellular/ molecular pathways of the skin affected by the aging process. However, a review of these strategies is required to discuss their efficacy/safety and establish the needs for further research.

Objective: Innovative nanotechnological advances for skin anti-aging/rejuvenation are summarized and discussed in this work.

Methods: The information in this review was extracted from recent and relevant studies using nanotechnology for anti-aging treatment from scientific databases.

Results and Discussion: Results show an enhanced skin anti-aging effect of actives-loaded nanoparticles of next generation (nanostructured lipid carriers, fullerenes, transfersomes, protransfersomes, niosomes, ethosomes, transethosomes, glycerosomes, phytosomes) compared with nanocarriers of first generation or conventional formulations. Anti-aging active ingredients such as, flavonoids (rutin, hesperidin, quercetagetine, quercetin, epigallocatechin-3-gallate, myricetin, silibinin, curcuminoids, isoflavones); vitamins (E, D3, CoQ10); acids (hyaluronic, ascorbic, rosmarinic, gallic); extracts (Citrus sinensis, Tagetes erecta L., Achillea millefolium L., Citrus aurantium L., Glycyrrhiza glabra L., Aloe vera, propolis earned by Apis mellifera); and other compounds (adenosine, beta-glucan, heptapetide DEETGEF, resveratrol, cycloastragenol, melatonin, botulinum toxin, grapeseed oil), have been successfully entrapped into nanoparticles for skin rejuvenation. This encapsulation has improved their solubility, bioavailability, stability, permeability, and effectivity for skin anti-aging, providing a controlled drug release with minimized side effects.

Conclusion: Recent studies show a trend of anti-aging herbal active ingredients-loaded nanoparticles, enhancing the moisturizing, antioxidant, regenerating and photoprotective activity of the skin. Suitable safety/shelf-life stability of these novel formulations is key to a successful translation to the clinic/industry.

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