Regulation of Oxidative Stress and Cardioprotection in Diabetes Mellitus

Tetsuya      Hayashi; Tatsuhiko      Mori; Chika      Yamashita; Masatoshi      Miyamura

doi:10.2174/157340308786349426

Abstract

Analysis of the Framingham data has shown that the risk of heart failure is increased substantially among diabetic patients, while persons with the metabolic syndrome have an increased risk of both atherosclerosis and diabetes mellitus. Sleep apnea may be related to the metabolic syndrome and systemic inflammation through hypoxia, which might also cause the cardiac remodeling by increased oxidative stress. On the other hand, the renin-angiotensin system is activated in diabetes, and local angiotensin II production may lead to oxidative damage via the angiotensin II type 1 receptor. Basic and clinical data indicate that angiotensin II receptor blockers have the potential to preserve left ventricular function and prevent cardiac remodeling that is exaggerated by oxidative stress in patients with diabetes. Thus, alleviation of oxidative stress might be one possible strategy in the treatment of diabetic patients associated with sleep apnea.

Keywords: Oxidative stress, diabetes mellitus, sleep apnea, hypoxia, remodeling