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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Review Article

Cytotoxicity and membrane perturbation associated with the myristylated n-terminal portion of hiv-1 gag protein

Author(s): C. C. Curtain and I. G. Macreadie*

Volume 7, Issue 1, 2000

Page: [37 - 42] Pages: 6

DOI: 10.2174/092986650701221205155142

Price: $65

Abstract

The Gag and Nef proteins of human immunodeficiency type l (HIV-1) have conserved N-terminal sequences that appear essential for HIV-1 function. In view of the structural similarities a Gag peptide corresponding to myrGag2_22, was subjected to cytotoxicity tests employing recently developed cell assays. The Gag peptide displays a similar activity to Nef. The role of such sequences may be important in viral membrane association, viral biogenesis and transition of these proteins through the cellular membrane.


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