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Current Pediatric Reviews

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ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

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Review Article

Cord Blood Sampling - A Review of Umbilical Cord Blood Use for Admission Laboratory Tests in the Immediate Newborn Period

Author(s): Patrick D. Carroll*

Volume 19, Issue 4, 2023

Published on: 21 December, 2022

Page: [371 - 375] Pages: 5

DOI: 10.2174/1573396319666221125140556

Price: $65

Abstract

Historically blood for admission laboratory studies in neonates was obtained through direct neonatal phlebotomy. Over the past decade, there has been a significant increase in studies evaluating the validity and clinical impact of using a cord blood sample for many admission laboratory studies. This article reviews various studies that together suggest that using cord blood samples for admission testing in neonates is both acceptable and beneficial.

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Graphical Abstract

[1]
Martin JA, Hamilton BE, Osterman M. Births in the United States, 2020. NCHS Data Brief 2021; (418): 1-8.
[PMID: 34582330]
[2]
Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P. The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol 2018; 52: 3-12.
[http://dx.doi.org/10.1016/j.bpobgyn.2018.04.003] [PMID: 29779863]
[3]
Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371(9606): 75-84.
[http://dx.doi.org/10.1016/S0140-6736(08)60074-4] [PMID: 18177778]
[4]
Venkatesh KK, Lynch CD, Costantine MM, et al. Trends in active treatment of live-born neonates between 22 weeks 0 days and 25 weeks 6 days by gestational age and maternal race and ethnicity in the US, 2014 to 2020. JAMA 2022; 328(7): 652-62.
[http://dx.doi.org/10.1001/jama.2022.12841] [PMID: 35972487]
[5]
Backes CH, Rivera BK, Pavlek L, et al. Proactive neonatal treatment at 22 weeks of gestation: a systematic review and meta-analysis. Am J Obstet Gynecol 2021; 224(2): 158-74.
[http://dx.doi.org/10.1016/j.ajog.2020.07.051] [PMID: 32745459]
[6]
Nishida H, Sakuma I. Limit of viability in Japan: ethical consideration. J Perinat Med 2009; 37(5): 457-60.
[http://dx.doi.org/10.1515/JPM.2009.112] [PMID: 19673680]
[7]
Sisson TRC, Knutson S, Kendall N. The blood volume of infants. Am J Obstet Gynecol 1973; 117(3): 351-7.
[http://dx.doi.org/10.1016/0002-9378(73)90037-9] [PMID: 4580964]
[8]
Yao A, Lind J. Effect of gravity on placental transfusion. Lancet 1969; 294(7619): 505-8.
[http://dx.doi.org/10.1016/S0140-6736(69)90213-X] [PMID: 4184835]
[9]
Yao AC, Lind J, Tiisala R, Michelsson K. Placetal transfusion in the premature infant with observation on clinical course and outcome. Acta Paediatr 1969; 58(6): 561-6.
[http://dx.doi.org/10.1111/j.1651-2227.1969.tb04762.x] [PMID: 5393044]
[10]
Yao A, Moinian M, Lind J. Distribution of blood between infant and placenta after birth. Lancet 1969; 294(7626): 871-3.
[http://dx.doi.org/10.1016/S0140-6736(69)92328-9] [PMID: 4186454]
[11]
Aladangady N, McHugh S, Aitchison TC, Wardrop CAJ, Holland BM. Infants’ blood volume in a controlled trial of placental transfusion at preterm delivery. Pediatrics 2006; 117(1): 93-8.
[http://dx.doi.org/10.1542/peds.2004-1773] [PMID: 16396865]
[12]
Becquet O, Guyot D, Kuo P, et al. Respective effects of phlebotomy losses and erythropoietin treatment on the need for blood transfusion in very premature infants. BMC Pediatr 2013; 13(1): 176.
[http://dx.doi.org/10.1186/1471-2431-13-176] [PMID: 24165292]
[13]
Rosebraugh MR, Widness JA, Nalbant D, Veng-Pedersen P. A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia. Transfusion 2013; 53(6): 1353-60.
[http://dx.doi.org/10.1111/j.1537-2995.2012.03908.x] [PMID: 23033916]
[14]
Counsilman CE, Heeger LE, Tan R. Iatrogenic blood loss in extreme preterm infants due to frequent laboratory tests and procedures. J Matern al-Fetal Neonat Med 2019; 34(16): 2660-5.
[15]
Carroll PD, Christensen RD. New and underutilized uses of umbilical cord blood in neonatal care. Matern Health Neonatol Perinatol 2015; 1(1): 16.
[http://dx.doi.org/10.1186/s40748-015-0017-2] [PMID: 27057333]
[16]
Hansen A, Forbes P, Buck R. Potential substitution of cord blood for infant blood in the neonatal sepsis evaluation. Neonatology 2005; 88(1): 12-8.
[http://dx.doi.org/10.1159/000083946] [PMID: 15711036]
[17]
Baer VL, Lambert DK, Carroll PD, Gerday E, Christensen RD. Using umbilical cord blood for the initial blood tests of VLBW neonates results in higher hemoglobin and fewer RBC transfusions. J Perinatol 2013; 33(5): 363-5.
[http://dx.doi.org/10.1038/jp.2012.127]
[18]
Beeram MR, Loughran C, Cipriani C, Govande V. Utilization of umbilical cord blood for the evaluation of group B streptococcal sepsis screening. Clin Pediatr (Phila) 2012; 51(5): 447-53.
[http://dx.doi.org/10.1177/0009922811431882] [PMID: 22199177]
[19]
Carroll PD, Nankervis CA, Iams J, Kelleher K. Umbilical cord blood as a replacement source for admission complete blood count in premature infants. J Perinatol 2011; 32(2): 97-102.
[PMID: 21566570]
[20]
Christensen RD, Lambert DK, Baer VL, et al. Postponing or eliminating red blood cell transfusions of very low birth weight neonates by obtaining all baseline laboratory blood tests from otherwise discarded fetal blood in the placenta. Transfusion 2011; 51(2): 253-8.
[http://dx.doi.org/10.1111/j.1537-2995.2010.02827.x] [PMID: 20723166]
[21]
Greer R, Safarulla A, Koeppel R, Aslam M, Bany-Mohammed FM. Can fetal umbilical venous blood be a reliable source for admission complete blood count and culture in NICU patients? Neonatology 2019; 115(1): 49-58.
[http://dx.doi.org/10.1159/000491993] [PMID: 30300890]
[22]
Medeiros PDB, Stark M, Long M, Allen E, Grace E, Andersen C. Feasibility and accuracy of cord blood sampling for admission laborato-ry investigations: A pilot trial. J Paediatr Child Health 2021; 57(5): 611-7.
[http://dx.doi.org/10.1111/jpc.15273] [PMID: 33171536]
[23]
Rotshenker-Olshinka K, Shinwell ES, Juster-Reicher A, Rosin I, Flidel-Rimon O. Comparison of hematologic indices and markers of infection in umbilical cord and neonatal blood. J Matern al-Fetal Neonat Med 2014; 27(6): 625-8.
[http://dx.doi.org/10.3109/14767058.2013.825597]
[24]
Grevsen AK, Hviid CVB, Hansen AK, Hvas AM. Platelet count and function in umbilical cord blood versus peripheral blood in term neo-nates. Platelets 2021; 32(5): 626-32.
[http://dx.doi.org/10.1080/09537104.2020.1786040] [PMID: 32631163]
[25]
Raffaeli G, Tripodi A, Manzoni F, et al. Is placental blood a reliable source for the evaluation of neonatal hemostasis at birth? Transfusion 2020; 60(5): 1069-77.
[http://dx.doi.org/10.1111/trf.15785] [PMID: 32315090]
[26]
Kellogg JA, Manzella JP, Bankert DA. Frequency of low-level bacteremia in children from birth to fifteen years of age. J Clin Microbiol 2000; 38(6): 2181-5.
[http://dx.doi.org/10.1128/JCM.38.6.2181-2185.2000] [PMID: 10834973]
[27]
Connell TG, Rele M, Cowley D, Buttery JP, Curtis N. How reliable is a negative blood culture result? Volume of blood submitted for cul-ture in routine practice in a children’s hospital. Pediatrics 2007; 119(5): 891-6.
[http://dx.doi.org/10.1542/peds.2006-0440] [PMID: 17473088]
[28]
Gonsalves WI, Cornish N, Moore M, Chen A, Varman M. Effects of volume and site of blood draw on blood culture results. J Clin Microbiol 2009; 47(11): 3482-5.
[http://dx.doi.org/10.1128/JCM.02107-08] [PMID: 19794050]
[29]
Woodford EC, Dhudasia MB, Puopolo KM, et al. Neonatal blood culture inoculant volume: feasibility and challenges. Pediatr Res 2021; 90(5): 1086-92.
[http://dx.doi.org/10.1038/s41390-021-01484-9] [PMID: 33824451]
[30]
Herson VC, Block C, McLaughlin JC, Tetreault J, Eisenfeld LI, Krause PJ. Placental blood sampling: An aid to the diagnosis of neonatal sepsis. J Perinatol 1998; 18(2): 135-7.
[PMID: 9605305]
[31]
Polin JI, Knox I, Baumgart S, Campman E, Mennuti MT, Polin RA. Use of umbilical cord blood culture for detection of neonatal bactere-mia. Obstet Gynecol 1981; 57(2): 233-7.
[PMID: 7465130]
[32]
Alissa R, Williams PD, Baker EL, Hipp JA, Saremian J, Aysola AE. Suitability of placental blood samples of newborns for pre-transfusion testing. Front Pediatr 2021; 9, 661321.
[http://dx.doi.org/10.3389/fped.2021.661321] [PMID: 33996695]
[33]
Judd WJ. Practice guidelines for prenatal and perinatal immunohematology, revisited. Transfusion 2001; 41(11): 1445-52.
[http://dx.doi.org/10.1046/j.1537-2995.2001.41111445.x] [PMID: 11724993]
[34]
Miller J. Newborn Screening Guidelines for Premature and/or Sick Newborns; Proposed Guidelines. Wayne, PA: Clinical and Laboratory Standards Institute 2008.
[35]
Balasubramanian H, Malpani P, Sindhur M, Kabra NS, Ahmed J, Srinivasan L. Effect of Umbilical Cord Blood Sampling versus Admission Blood Sampling on Requirement of Blood Transfusion in Extremely Preterm Infants: A Randomized Controlled Trial. J Pediatr 2019; 211: 39-45.e2.
[http://dx.doi.org/10.1016/j.jpeds.2019.04.033] [PMID: 31113718]
[36]
Mu TS, Prescott AC, Haischer-Rollo GD, Aden JK, Shapiro JB. Umbilical Cord Blood Use for Admission Blood Tests of VLBW Preterm Neonates: A Randomized Control Trial. Am J Perinatol 2021. Epub ahead of print
[http://dx.doi.org/10.1055/s-0041-1733781] [PMID: 34407547]
[37]
Carroll PD, Livingston E, Baer VL, Karkula K, Christensen RD. Evaluating otherwise-discarded umbilical cord blood as a source for a neonate’s complete blood cell count at various time points. Neonatology 2018; 114(1): 82-6.
[http://dx.doi.org/10.1159/000488024] [PMID: 29719291]
[38]
George R. Use of Cord Blood for Admissoin Lab Testing in High Risk Neonates, School of Nursing. Baltimore: University of Maryland 2019.
[39]
American Academy of Pediatrics and Subcommittee on Hyperbilirubinemia Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation 2004.
[40]
Josephson C, Meyer E. Neonatal and Pediatric transfusion practice. American Association of Blood Banking Technical Manual 2011; pp. 645-70.

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