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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Research Article

The Diagnostic and Prognostic Value of Plasma Circulating CircNUP98 for Nasopharyngeal Carcinoma

Author(s): Bin Zhang, Bohuai Xu, Lujie Yu, Yingying Pei and Yong He*

Volume 24, Issue 2, 2024

Published on: 22 December, 2022

Page: [226 - 232] Pages: 7

DOI: 10.2174/1566524023666221103152824

Price: $65

Abstract

Background: Our preliminary sequencing analysis revealed increased expression levels of circNUP98 in nasopharyngeal carcinoma (NPC). This study was therefore carried out to explore the role of circNUP98 in NPC.

Methods: The present study enrolled 56 patients with NPC, 44 patients with cervical lymphadenitis (CL), 50 patients with nose bleeding (NB), 50 patients with chronic sinusitis (CS), 50 patients with lymph node tuberculosis (LNT), and 50 healthy controls (Control). Plasma samples were obtained from all patients and the controls. In addition, NPC and paired non-tumor tissue samples were collected from the 56 NPC patients. The expression of circNUP98 in both tissue and plasma samples was determined by RT-qPCR. The 56 NPC patients were followed up for 5 years to analyze the associations between plasma expression of circNUP98 and the survival of patients. The diagnostic value of circNUP98 for NPC was analyzed through ROC curve analysis.

Results: The plasma expression levels of circNUP98 were only increased in NPC, but not in CL, NB, CS and LNT groups compared to that in the Control group. In addition, increased expression levels of circNUP98 were observed in NPC tissues compared to that in non-tumor tissues. Plasma circNUP98 was closely correlated with circNUP98 in NPC tissues, but not circNUP98 in non-tumor tissues. With plasma circNUP98 as a biomarker, NPC patients were separated from CL, NB, CS, LNT, and the Control groups. The Plasma expression of circNUP98 was found to be positively correlated with the poor survival of patients. Moreover, plasma circNUP98 was only closely associated with tumor metastasis, but not tumor size.

Conclusion: The expression of circNUP98 in plasma may be used to diagnose NPC and predict patients’ survival.

« Previous Next »
[1]
Chua MLK, Wee JTS, Hui EP, Chan ATC. Nasopharyngeal carcinoma. Lancet 2016; 387(10022): 1012-24.
[http://dx.doi.org/10.1016/S0140-6736(15)00055-0] [PMID: 26321262]
[2]
Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet 2019; 394(10192): 64-80.
[http://dx.doi.org/10.1016/S0140-6736(19)30956-0] [PMID: 31178151]
[3]
Tang LL, Chen WQ, Xue WQ, et al. Global trends in incidence and mortality of nasopharyngeal carcinoma. Cancer Lett 2016; 374(1): 22-30.
[http://dx.doi.org/10.1016/j.canlet.2016.01.040] [PMID: 26828135]
[4]
Wei KR, Zheng RS, Zhang SW, Liang ZH, Ou ZX, Chen WQ. Nasopharyngeal carcinoma incidence and mortality in China in 2010. Chin J Cancer 2014; 33(8): 381-7.
[PMID: 25096544]
[5]
Xu ZX, Lin ZX, Fang JY, et al. Mortality characteristic and prediction of nasopharyngeal carcinoma in China from 1991 to 2013. Asian Pac J Cancer Prev 2015; 16(15): 6729-34.
[http://dx.doi.org/10.7314/APJCP.2015.16.15.6729] [PMID: 26434902]
[6]
Fu ZT, Guo XL, Zhang SW, et al. Incidence and mortality of nasopharyngeal carcinoma in China, 2014. Zhonghua Zhong Liu Za Zhi 2018; 40(8): 566-71.
[PMID: 30139025]
[7]
Li C, Wang Y. Factors associated with early diagnosis in pediatric vs adult nasopharyngeal carcinoma. Acta Otolaryngol 2018; 138(1): 56-9.
[http://dx.doi.org/10.1080/00016489.2017.1371330] [PMID: 28875765]
[8]
Wang KH, Austin SA, Chen SH, Sonne DC, Gurushanthaiah D. Nasopharyngeal carcinoma diagnostic challenge in a nonen-demic setting: our experience with 101 patients. Perm J 2017; 21(3): 16-180.
[http://dx.doi.org/10.7812/TPP/16-180] [PMID: 28609261]
[9]
Mo L, Kuang G, Huang G, Yang R. Effects on distant metastasis of misdiagnosis of nasopharyngeal carcinoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007; 21(24): 1124-6.
[PMID: 18330260]
[10]
Wong KCW, Hui EP, Lo KW, et al. Nasopharyngeal carcinoma: an evolving paradigm. Nat Rev Clin Oncol 2021; 18(11): 679-95.
[http://dx.doi.org/10.1038/s41571-021-00524-x] [PMID: 34194007]
[11]
Li X, Fasano R, Wang E, Yao KT, Marincola F. HLA associations with nasopharyngeal carcinoma. Curr Mol Med 2009; 9(6): 751-65.
[http://dx.doi.org/10.2174/156652409788970698] [PMID: 19689302]
[12]
Goel A, Aman, Narayan J, Raheja V, Saini M. Unusual presentation of pediatric nasopharyngeal carcinoma as acute cervical lymphadenitis. IP J Otorhinolaryngol Alli Sci 2019; 2019: 2108-10.
[13]
Huang PW, Chiou YR, Wu SL, Liu JC, Chiou KR. Risk of nasopharyngeal carcinoma in patients with chronic rhinosinusitis: A nationwide propensity score matched study in Taiwan. Asia Pac J Clin Oncol 2020; 17(6): 442-7.
[PMID: 32970941]
[14]
Ge Y, He Z, Xiang Y, et al. The identification of key genes in nasopharyngeal carcinoma by bioinformatics analysis of high-throughput data. Mol Biol Rep 2019; 46(3): 2829-40.
[http://dx.doi.org/10.1007/s11033-019-04729-3] [PMID: 30830589]
[15]
Li J, Zhou C, Wang G, et al. Promoter hypermethylation of SLIT2 is a risk factor and potential diagnostic biomarker for naso-pharyngeal carcinoma. Gene 2018; 644: 74-9.
[http://dx.doi.org/10.1016/j.gene.2017.10.059] [PMID: 29107007]
[16]
Liu L, Zuo L, Yang J, et al. Exosomal cyclophilin A as a novel noninvasive biomarker for Epstein‐Barr virus associated naso-pharyngeal carcinoma. Cancer Med 2019; 8(6): 3142-51.
[http://dx.doi.org/10.1002/cam4.2185] [PMID: 31063269]
[17]
Shang Q, Yang Z, Jia R, Ge S. The novel roles of circRNAs in human cancer. Mol Cancer 2019; 18(1): 6.
[http://dx.doi.org/10.1186/s12943-018-0934-6] [PMID: 30626395]
[18]
Wang M, Yang Y, Xu J, Bai W, Ren X, Wu H. CircRNAs as biomarkers of cancer: a meta-analysis. BMC Cancer 2018; 18(1): 303.
[http://dx.doi.org/10.1186/s12885-018-4213-0] [PMID: 29554887]
[19]
Yu R, Yao J, Ren Y. A novel circRNA, circNUP98, a potential biomarker, acted as an oncogene via the miR‐567/PRDX3 axis in renal cell carcinoma. J Cell Mol Med 2020; 24(17): 10177-88.
[http://dx.doi.org/10.1111/jcmm.15629] [PMID: 32729669]
[20]
Shuai M, Hong J, Huang D, Zhang X, Tian Y. Upregulation of circRNA_0000285 serves as a prognostic biomarker for naso-pharyngeal carcinoma and is involved in radiosensitivity. Oncol Lett 2018; 16(5): 6495-501.
[http://dx.doi.org/10.3892/ol.2018.9471] [PMID: 30405788]
[21]
Zhu L, Liu Y, Yang Y, Mao XM, Yin ZD. CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p. Eur Rev Med Pharmacol Sci 2019; 23(7): 2817-26.
[PMID: 31002133]

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