Recent Applications of Bioinformatics in Target Identification and Drug Discovery for Alzheimer’s Disease

Title:Recent Applications of Bioinformatics in Target Identification and Drug Discovery for Alzheimer’s Disease

Volume: 22 Issue: 26

Author(s): Sushil Kumar Singh*, Ashok Kumar, Ravi Bhushan Singh, Powsali Ghosh and Nilesh Gajanan Bajad

Affiliation:

• Pharmaceutical Chemistry Research Laboratory I, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India

Abstract: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disease characterized by progressive memory loss. The main pathological features of the disease are extracellular deposition of amyloid β (Aβ) plaques and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. Understanding factors contributing to AD progression, the number of molecular signatures, and the development of therapeutic agents played a significant role in the discovery of disease-modifying drugs to treat the disease. Bioinformatics has established its significance in many areas of biology. The role of bioinformatics in drug discovery, is emerging significantly and will continue to evolve. In recent years, different bioinformatics methodologies, viz. protein signaling pathway, molecular signature differences between different classes of drugs, interacting profiles of drugs and their potential therapeutic mechanisms, have been applied to identify potential therapeutic targets of AD. Bioinformatics tools were also found to contribute to the discovery of novel drugs, omics-based biomarkers, and drug repurposing for AD. The review aims to explore the applications of various advanced bioinformatics tools in the identification of targets, biomarkers, pathways, and potential therapeutics for the treatment of the disease.

Cite this article as:

Singh Kumar Sushil*, Kumar Ashok, Singh Bhushan Ravi, Ghosh Powsali and Bajad Gajanan Nilesh, Recent Applications of Bioinformatics in Target Identification and Drug Discovery for Alzheimer’s Disease, Current Topics in Medicinal Chemistry 2022; 22 (26) . https://dx.doi.org/10.2174/1568026623666221026091010