Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Research Article

DPP-Cu2+ Complexes Gated Mesoporous Silica Nanoparticles For pH and Redox Dual Stimuli-Responsive Drug Delivery

Author(s): Wei Chen, Mingyang Ma, Qingteng Lai, Yanke Zhang and Zhengchun Liu*

Volume 30, Issue 28, 2023

Published on: 28 November, 2022

Page: [3249 - 3260] Pages: 12

DOI: 10.2174/0929867329666221011110504

Price: $65

Abstract

Objective: A simple pH and redox dual stimuli-responsive diketopyrrolopyrrole (DPP)-Cu2+ complexes gated mesoporous silica nanoparticles (MSN) were prepared for precise drug delivery and controlled drug release.

Method: MSN was prepared by sol-gel method and then laminated. Carboxylic acid (CA)-Pyrrolo[3,4-c] pyrrole-1,4-dione, 2,5-dihydro-3,6-di-2-pyridinyl (PyDPP) was grafted onto the surface of amino-functionalized MSN (MSN-NH2) through a simple amide reaction and then complexed with Cu2+ to form gated molecules after doxorubicin (DOX) loading.

Results: Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Low-angle X-ray diffraction (XRD) showed that MSN with uniform particle size (100 nm) and porous structure was successfully prepared. The prepared MSN, MSN- NH2, and MSN-DPP were fully characterized by Zeta potential, Fourier transforms infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and nitrogen adsorption- desorption. High DOX-loading capacity (18.22%) and encapsulation efficiency (89.16%) were achieved by optimizing the mass ratio of MSN to DOX. Release studies showed that the gated molecules of our designed DPP-Cu2+ complexes had a good blocking effect under physiological conditions (the cumulative release rate of drugs within 24 hours was only 4.18%) and responded well to the pH and redox glutathione (GSH) dual stimuli. In vitro cytotoxicity assay showed that MSN-DPP-Cu2+ had good biocompatibility in both Hep G2 cells and L02 cells (the relative cell viability of both cells within 48 hours was above 97%), and the MSN-DPP-Cu2+@DOX could be triggered for efficient drug release in Hep G2 cells.

Conclusion: The MSN-DPP-Cu2+ described in this research may be a good delivery system for the controlled release of antitumor drugs and can provide a potential possibility for clinical application in the future.

[1]
Bakken, E.; Heruth, K. Temporal control of drugs: An engineering perspective. Ann. N. Y. Acad. Sci., 1991, 618(1 Temporal Cont), 422-427.
[http://dx.doi.org/10.1111/j.1749-6632.1991.tb27261.x]
[2]
Corti, A.; Pastorino, F.; Curnis, F.; Arap, W.; Ponzoni, M.; Pasqualini, R. Targeted drug delivery and penetration into solid tumors. Med. Res. Rev., 2012, 32(5), 1078-1091.
[http://dx.doi.org/10.1002/med.20238] [PMID: 21287572]
[3]
Zhang, J.; Wu, D.; Li, M.F.; Feng, J. Multifunctional mesoporous silica nanoparticles based on charge-reversal plug-gate nanovalves and acid-decomposable ZnO quantum dots for intracellular drug delivery. ACS Appl. Mater. Interfaces, 2015, 7(48), 26666-26673.
[http://dx.doi.org/10.1021/acsami.5b08460] [PMID: 26553405]
[4]
van der Koog, L.; Gandek, T.B.; Nagelkerke, A. Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization. Adv. Healthc. Mater., 2022, 11(5), 2100639.
[http://dx.doi.org/10.1002/adhm.202100639] [PMID: 34165909]
[5]
Antoniou, A.I.; Giofrè, S.; Seneci, P.; Passarella, D.; Pellegrino, S. Stimulus-responsive liposomes for biomedical applications. Drug Discov. Today, 2021, 26(8), 1794-1824.
[http://dx.doi.org/10.1016/j.drudis.2021.05.010] [PMID: 34058372]
[6]
Eygeris, Y.; Gupta, M.; Kim, J.; Sahay, G. Chemistry of lipid nanoparticles for RNA delivery. Acc. Chem. Res., 2022, 55(1), 2-12.
[http://dx.doi.org/10.1021/acs.accounts.1c00544] [PMID: 34850635]
[7]
Mignani, S.; Shi, X.; Ceña, V.; Majoral, J.P. Dendrimer– and polymeric nanoparticle–aptamer bioconjugates as nonviral delivery systems: A new approach in medicine. Drug Discov. Today, 2020, 25(6), 1065-1073.
[http://dx.doi.org/10.1016/j.drudis.2020.03.009] [PMID: 32283193]
[8]
Lin, M.; Dai, Y.; Xia, F.; Zhang, X. Advances in non-covalent crosslinked polymer micelles for biomedical applications. Mater. Sci. Eng. C, 2021, 119, 111626.
[http://dx.doi.org/10.1016/j.msec.2020.111626] [PMID: 33321667]
[9]
Birk, S.E.; Boisen, A.; Nielsen, L.H. Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms. Adv. Drug Deliv. Rev., 2021, 174, 30-52.
[http://dx.doi.org/10.1016/j.addr.2021.04.005] [PMID: 33845040]
[10]
Ghosh, B.; Biswas, S. Polymeric micelles in cancer therapy: State of the art. J. Control. Release, 2021, 332, 127-147.
[http://dx.doi.org/10.1016/j.jconrel.2021.02.016] [PMID: 33609621]
[11]
Tyler, B.; Gullotti, D.; Mangraviti, A.; Utsuki, T.; Brem, H. Polylactic acid (PLA) controlled delivery carriers for biomedical applications. Adv. Drug Deliv. Rev., 2016, 107, 163-175.
[http://dx.doi.org/10.1016/j.addr.2016.06.018] [PMID: 27426411]
[12]
Sharifi, M.; Attar, F.; Saboury, A.A.; Akhtari, K.; Hooshmand, N.; Hasan, A.; El-Sayed, M.A.; Falahati, M. Plasmonic gold nanoparticles: Optical manipulation, imaging, drug delivery and therapy. J. Control. Release, 2019, 311-312, 170-189.
[http://dx.doi.org/10.1016/j.jconrel.2019.08.032] [PMID: 31472191]
[13]
Liu, X.Y.; Wang, J.Q.; Ashby, C.R., Jr; Zeng, L.; Fan, Y.F.; Chen, Z.S. Gold nanoparticles: Synthesis, physiochemical properties and therapeutic applications in cancer. Drug Discov. Today, 2021, 26(5), 1284-1292.
[http://dx.doi.org/10.1016/j.drudis.2021.01.030] [PMID: 33549529]
[14]
Vangijzegem, T.; Stanicki, D.; Laurent, S. Magnetic iron oxide nanoparticles for drug delivery: Applications and characteristics. Expert Opin. Drug Deliv., 2019, 16(1), 69-78.
[http://dx.doi.org/10.1080/17425247.2019.1554647] [PMID: 30496697]
[15]
Singh, T.A.; Das, J.; Sil, P.C. Zinc oxide nanoparticles: A comprehensive review on its synthesis, anticancer and drug delivery applications as well as health risks. Adv. Colloid Interface Sci., 2020, 286, 102317.
[http://dx.doi.org/10.1016/j.cis.2020.102317] [PMID: 33212389]
[16]
Zare, H.; Ahmadi, S.; Ghasemi, A.; Ghanbari, M.; Rabiee, N.; Bagherzadeh, M.; Karimi, M.; Webster, T.J.; Hamblin, M.R.; Mostafavi, E. Carbon nanotubes: Smart drug/gene delivery carriers. Int. J. Nanomedicine, 2021, 16, 1681-1706.
[http://dx.doi.org/10.2147/IJN.S299448] [PMID: 33688185]
[17]
Chen, L.; Zhao, T.; Zhao, M.; Wang, W.; Sun, C.; Liu, L.; Li, Q.; Zhang, F.; Zhao, D.; Li, X. Size and charge dual- transformable mesoporous nanoassemblies for enhanced drug delivery and tumor penetration. Chem. Sci. (Camb.), 2020, 11(10), 2819-2827.
[http://dx.doi.org/10.1039/C9SC06260B] [PMID: 34084342]
[18]
Zhao, F.; Zhang, C.; Zhao, C.; Gao, W.; Fan, X.; Wu, G. A facile strategy to fabricate a pH-responsive mesoporous silica nanoparticle end-capped with amphiphilic peptides by self-assembly. Colloids Surf. B Biointerfaces, 2019, 179, 352-362.
[http://dx.doi.org/10.1016/j.colsurfb.2019.03.019] [PMID: 30991215]
[19]
Zhang, J.; Shen, B.; Chen, L.; Chen, L.; Meng, Y.; Feng, J. A dual-sensitive mesoporous silica nanoparticle based drug carrier for cancer synergetic therapy. Colloids Surf. B Biointerfaces, 2019, 175, 65-72.
[http://dx.doi.org/10.1016/j.colsurfb.2018.11.071] [PMID: 30522009]
[20]
Yan, Q.; Guo, X.; Huang, X.; Meng, X.; Liu, F.; Dai, P.; Wang, Z.; Zhao, Y. Gated mesoporous silica nanocarriers for hypoxia-responsive cargo release. ACS Appl. Mater. Interfaces, 2019, 11(27), 24377-24385.
[http://dx.doi.org/10.1021/acsami.9b04142] [PMID: 31195793]
[21]
Castillo, R.R.; Lozano, D.; González, B.; Manzano, M.; Izquierdo-Barba, I.; Vallet-Regí, M. Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: An update. Expert Opin. Drug Deliv., 2019, 16(4), 415-439.
[http://dx.doi.org/10.1080/17425247.2019.1598375] [PMID: 30897978]
[22]
Rahikkala, A.; Pereira, S.A.P.; Figueiredo, P.; Passos, M.L.C.; Araújo, A.R.T.S.; Saraiva, M.L.M.F.S.; Santos, H.A. Mesoporous silica nanoparticles for targeted and stimuli-responsive delivery of chemotherapeutics: A review. Adv. Biosyst., 2018, 2(7), 1800020.
[http://dx.doi.org/10.1002/adbi.201800020]
[23]
Liong, M.; Lu, J.; Tamanoi, F.; Zink, J.I. Google patents US20100255103A1. June 12, 2018.
[24]
Zhou, S.; Ding, C.; Wang, C.; Fu, J. UV-light cross-linked and pH de-cross-linked coumarin-decorated cationic copolymer grafted mesoporous silica nanoparticles for drug and gene co-delivery in vitro. In: Materials Science & Engineering C-Materials for Biological Applications; , 2020; p. 108.
[25]
Yang, C.; Shi, Z.; Feng, C.; Li, R.; Luo, S.; Li, X.; Ruan, L. An adjustable pH-responsive drug delivery system based on self-assembly polypeptide-modified mesoporous silica. Macromol. Biosci., 2020, 20(6), 2000034.
[http://dx.doi.org/10.1002/mabi.202000034] [PMID: 32329202]
[26]
Yang, B.; Zhou, S.; Zeng, J.; Zhang, L.; Zhang, R.; Liang, K.; Xie, L.; Shao, B.; Song, S.; Huang, G.; Zhao, D.; Chen, P.; Kong, B. Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy. Nano Res., 2020, 13(4), 1013-1019.
[http://dx.doi.org/10.1007/s12274-020-2736-6]
[27]
Lu, J.; Luo, B.; Chen, Z.; Yuan, Y.; Kuang, Y.; Wan, L.; Yao, L.; Chen, X.; Jiang, B.; Liu, J.; Li, C. Host-guest fabrication of dual-responsive hyaluronic acid/mesoporous silica nanoparticle based drug delivery system for targeted cancer therapy. Int. J. Biol. Macromol., 2020, 146, 363-373.
[http://dx.doi.org/10.1016/j.ijbiomac.2019.12.265] [PMID: 31911174]
[28]
Chen, C.; Yao, W.; Sun, W.; Guo, T.; Lv, H.; Wang, X.; Ying, H.; Wang, Y.; Wang, P. A self-targeting and controllable drug delivery system constituting mesoporous silica nanoparticles fabricated with a multi-stimuli responsive chitosan-based thin film layer. Int. J. Biol. Macromol., 2019, 122, 1090-1099.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.09.058] [PMID: 30219514]
[29]
Lin, J.T.; Ye, Q.B.; Yang, Q.J.; Wang, G.H. Hierarchical bioresponsive nanocarriers for codelivery of curcumin and doxorubicin. Colloids Surf. B Biointerfaces, 2019, 180, 93-101.
[http://dx.doi.org/10.1016/j.colsurfb.2019.04.023] [PMID: 31035057]
[30]
Wang, S.; Liu, H.; Wu, D.; Wang, X. Temperature and pH dual-stimuli-responsive phase-change microcapsules for multipurpose applications in smart drug delivery. J. Colloid Interface Sci., 2021, 583, 470-486.
[http://dx.doi.org/10.1016/j.jcis.2020.09.073] [PMID: 33011414]
[31]
Luo, Q.; Lin, L.; Huang, Q.; Duan, Z.; Gu, L.; Zhang, H.; Gu, Z.; Gong, Q.; Luo, K. Dual stimuli-responsive dendronized prodrug derived from poly(oligo-(ethylene glycol) methacrylate)-based copolymers for enhanced anti- cancer therapeutic effect. Acta Biomater., 2022, 143, 320-332.
[http://dx.doi.org/10.1016/j.actbio.2022.02.033] [PMID: 35235863]
[32]
Wei, D.; Tong, Q.; An, Q.; Ma, X.; Jiang, X.; Li, X.; Yi, Z. Dual stimuli-responsive nanocarriers based on polyethylene glycol-mediated schiff base interactions for overcoming tumour chemoresistance. Colloids Surf. B Biointerfaces, 2022, 213, 112408.
[http://dx.doi.org/10.1016/j.colsurfb.2022.112408] [PMID: 35168105]
[33]
Zegota, M.M.; Müller, M.A.; Lantzberg, B.; Kizilsavas, G.; Coelho, J.A.S.; Moscariello, P.; Martínez-Negro, M.; Morsbach, S.; Gois, P.M.P.; Wagner, M.; Ng, D.Y.W.; Kuan, S.L.; Weil, T. Dual stimuli-responsive dynamic covalent peptide tags: Toward sequence-controlled release in tumor-like microenvironments. J. Am. Chem. Soc., 2021, 143(41), 17047-17058.
[http://dx.doi.org/10.1021/jacs.1c06559] [PMID: 34632780]
[34]
Gao, M.; Han, Z.; Zhang, X.; Zou, X.; Peng, L.; Zhao, Y.; Sun, L. Construction of double-shelled hollow Ag2s@polydopamine nanocomposites for fluorescence-guided, dual stimuli-responsive drug delivery and photothermal therapy. Nanomaterials (Basel), 2022, 12(12), 2068.
[http://dx.doi.org/10.3390/nano12122068]
[35]
Wang, Z.; Peng, Y.; Zhou, Y.; Zhang, S.; Tan, J.; Li, H.; He, D.; Deng, L. Pd-Cu nanoalloy for dual stimuli-responsive chemo-photothermal therapy against pathogenic biofilm bacteria. Acta Biomater., 2022, 137, 276-289.
[http://dx.doi.org/10.1016/j.actbio.2021.10.028] [PMID: 34715367]
[36]
He, T.; He, J.; Younis, M.R.; Blum, N.T.; Lei, S.; Zhang, Y.; Huang, P.; Lin, J. Dual-stimuli-responsive nanotheranostics for dual-targeting photothermal-enhanced chemotherapy of tumor. ACS Appl. Mater. Interfaces, 2021, 13(19), 22204-22212.
[http://dx.doi.org/10.1021/acsami.1c03211] [PMID: 33956444]
[37]
Xiao, Y.; Xu, M.; Lv, N.; Cheng, C.; Huang, P.; Li, J.; Hu, Y.; Sun, M. Dual stimuli-responsive metal-organic framework-based nanosystem for synergistic photothermal/pharmacological antibacterial therapy. Acta Biomater., 2021, 122, 291-305.
[http://dx.doi.org/10.1016/j.actbio.2020.12.045] [PMID: 33359766]
[38]
Wei, Y.; Yu, F.; Diao, Z.; Xu, R.; Li, H.; Qin, G.; Guo, X. Self-cleaning electrochemical protein-imprinting biosensor with a dual-driven switchable affinity for sensing bovine serum albumin. Talanta, 2022, 237, 122893.
[http://dx.doi.org/10.1016/j.talanta.2021.122893] [PMID: 34736709]
[39]
Shen, J.; Qiao, J.; Zhang, X.; Qi, L. Dual-stimuli-responsive porous polymer enzyme reactor for tuning enzymolysis efficiency. Mikrochim. Acta, 2021, 188(12), 435.
[http://dx.doi.org/10.1007/s00604-021-05095-3] [PMID: 34837525]
[40]
Ma, E.; Wang, K.; Hu, Z.; Wang, H. Dual-stimuli-responsive CuS-based micromotors for efficient photo-Fenton degradation of antibiotics. J. Colloid Interface Sci., 2021, 603, 685-694.
[http://dx.doi.org/10.1016/j.jcis.2021.06.142] [PMID: 34225072]
[41]
He, L.; Qin, X.; Fan, D.; Feng, C.; Wang, Q.; Fang, J. Dual-stimuli responsive polymeric micelles for the effective treatment of rheumatoid arthritis. ACS Appl. Mater. Interfaces, 2021, 13(18), 21076-21086.
[http://dx.doi.org/10.1021/acsami.1c04953] [PMID: 33913684]
[42]
Nie, K.; Xu, S.; Duan, X.; Shi, H.; Dong, B.; Long, M.; Xu, H.; Jiang, X.F.; Liu, Z. Diketopyrrolopyrrole-doped hybrid FONs as two-photon absorbing and dual-emission fluorescent nanosensors for Hg2+. Sens. Actuators B Chem., 2018, 265, 1-9.
[http://dx.doi.org/10.1016/j.snb.2018.03.026]
[43]
Nie, K.; Dong, B.; Shi, H.; Liu, Z.; Liang, B. Thienyl diketopyrrolopyrrole as a robust sensing platform for multiple ions and its application in molecular logic system. Sens. Actuators B Chem., 2017, 244, 849-853.
[http://dx.doi.org/10.1016/j.snb.2017.01.037]
[44]
Nie, K.; Dong, B.; Shi, H.; Liu, Z.; Liang, B. Diketopyrrolopyrrole amphiphile-based micelle-like fluorescent nanoparticles for selective and sensitive detection of mercury (II) ions in water. Anal. Chem., 2017, 89(5), 2928-2936.
[http://dx.doi.org/10.1021/acs.analchem.6b04258] [PMID: 28192984]
[45]
Nie, K.; Dong, B.; Shi, H.; Chao, L.; Huang, Z.; Long, M.; Xu, H.; Liu, Z.; Liang, B. Pyridyl DPP based soluble nanoaggregates for ratiometric/fluorescent detection of Cu2+/Hg2+ in water. J. Lumin., 2019, 208, 408-414.
[http://dx.doi.org/10.1016/j.jlumin.2018.12.046]
[46]
Schmitt, J.; Heitz, V.; Sour, A.; Bolze, F.; Ftouni, H.; Nicoud, J.F.; Flamigni, L.; Ventura, B. Diketopyrrolopyrrole- porphyrin conjugates with high two-photon absorption and singlet oxygen generation for two-photon photodynamic therapy. Angew. Chem. Int. Ed., 2015, 54(1), 169-173.
[http://dx.doi.org/10.1002/anie.201407537] [PMID: 25370127]
[47]
Liang, P.; Wang, Y.; Wang, P.; Zou, J.; Xu, H.; Zhang, Y.; Si, W.; Dong, X. Triphenylamine flanked furan-diketopyrrolopyrrole for multi-imaging guided photothermal/photodynamic cancer therapy. Nanoscale, 2017, 9(47), 18890-18896.
[http://dx.doi.org/10.1039/C7NR07204J] [PMID: 29177329]
[48]
Li, C.; Wang, J.; Wang, Y.; Gao, H.; Wei, G.; Huang, Y.; Yu, H.; Gan, Y.; Wang, Y.; Mei, L.; Chen, H.; Hu, H.; Zhang, Z.; Jin, Y. Recent progress in drug delivery. Acta Pharm. Sin. B, 2019, 9(6), 1145-1162.
[http://dx.doi.org/10.1016/j.apsb.2019.08.003] [PMID: 31867161]
[49]
Qiu, Z.; Shu, J.; Tang, D. Bioresponsive release system for visual fluorescence detection of carcinoembryonic antigen from mesoporous silica nanocontainers mediated optical color on quantum dot-enzyme-impregnated paper. Anal. Chem., 2017, 89(9), 5152-5160.
[http://dx.doi.org/10.1021/acs.analchem.7b00989] [PMID: 28376620]
[50]
Roggers, R.A.; Lin, V.S.Y.; Trewyn, B.G. Chemically reducible lipid bilayer coated mesoporous silica nanoparticles demonstrating controlled release and HeLa and normal mouse liver cell biocompatibility and cellular internalization. Mol. Pharm., 2012, 9(9), 2770-2777.
[http://dx.doi.org/10.1021/mp200613y] [PMID: 22738645]
[51]
Chen, X.; Sun, H.; Hu, J.; Han, X.; Liu, H.; Hu, Y. Transferrin gated mesoporous silica nanoparticles for redox-responsive and targeted drug delivery. Colloids Surf. B Biointerfaces, 2017, 152, 77-84.
[http://dx.doi.org/10.1016/j.colsurfb.2017.01.010] [PMID: 28088015]
[52]
Chen, H.; Kuang, Y.; Liu, R.; Chen, Z.; Jiang, B.; Sun, Z.; Chen, X.; Li, C. Dual-pH-sensitive mesoporous silica nanoparticle-based drug delivery system for tumor-triggered intracellular drug release. J. Mater. Sci., 2018, 53(15), 10653-10665.
[http://dx.doi.org/10.1007/s10853-018-2363-8]
[53]
Zeng, X.; Liu, G.; Tao, W.; Ma, Y.; Zhang, X.; He, F.; Pan, J.; Mei, L.; Pan, G. A drug-self-gated mesoporous antitumor nanoplatform based on ph-sensitive dynamic covalent bond. Adv. Funct. Mater., 2017, 27(11), 1605985.
[http://dx.doi.org/10.1002/adfm.201605985]
[54]
Cheng, Y.J.; Luo, G.F.; Zhu, J.Y.; Xu, X.D.; Zeng, X.; Cheng, D.B.; Li, Y.M.; Wu, Y.; Zhang, X.Z.; Zhuo, R.X.; He, F. Enzyme-induced and tumor-targeted drug delivery system based on multifunctional mesoporous silica nanoparticles. ACS Appl. Mater. Interfaces, 2015, 7(17), 9078-9087.
[http://dx.doi.org/10.1021/acsami.5b00752] [PMID: 25893819]

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version324msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[21:37:36] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[21:37:36] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[21:37:36] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[21:37:36] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[21:37:36] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (96.48ms)time
  • Application (228ms)time
  • 1 x Application (70.26%)
    228ms
    1 x Booting (29.74%)
    96.48ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    36 statements were executed, 4 of which were duplicates, 32 unique. Show only duplicated150ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316307720','',1,1740346656,1740346656) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740346656
      1.09msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316307720','/article/126916',1,1740346656,1740346656)
      170μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316307720 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316307720) limit 1
      11.75msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316307720
      • 1: 316307720
      • 2: 316307720
      • 3: 316307720
      • 4: 316307720
      • 5: 316307720
      • 6: 316307720
      • 7: 316307720
      • 8: 316307720
      • 9: 316307720
      • 10: 316307720
      • 11: 316307720
      • 12: 316307720
      • 13: 316307720
      • 14: 316307720
      • 15: 316307720
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=126916
      650μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 25 limit 1
      730μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 25
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=25) and sj.journal_id!=25 group by `j`.`nid`) as `aggregate_table`
      1.31msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=25) and sj.journal_id!=25 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      1.11msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=25) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      3.42msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=25) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      2.92msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '126916'
      200μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 126916
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '126916'
      3.6msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 126916
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '126916' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      1.53msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 126916
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      230μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      450μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 25 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      38msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 25 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      32.29msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 25 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      29.87msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 126916 limit 1
      170μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 126916
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 126916 and content_type = 'article' order by status desc limit 1
      220μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 209840 limit 1
      190μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 209840
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      200μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CMC' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      320μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CMC
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '126916' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      360μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '12432' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      280μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3321' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      260μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316307720 and j.to_ip >=316307720 )) and ((j.from_date <= 1740346656 and j.to_date >= 1740346656 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3321) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316307720 and j.to_ip >=316307720 )) and ((j.from_date <= 1740346656 and j.to_date >= 1740346656 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3321) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316307720 and j.to_ip >=316307720 )) and ((j.from_date <= 1740346656 and j.to_date >= 1740346656 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3321)
      11.64msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316307720 and j.to_ip >=316307720 )) and ((j.from_date <= 1740346656 and j.to_date >= 1740346656 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12432) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316307720 and j.to_ip >=316307720 )) and ((j.from_date <= 1740346656 and j.to_date >= 1740346656 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12432) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316307720 and j.to_ip >=316307720 )) and ((j.from_date <= 1740346656 and j.to_date >= 1740346656 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12432)
      600μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316307720 and j.to_ip >=316307720 )) and ((j.from_date <= 1740346656 and j.to_date >= 1740346656 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 126916) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316307720 and j.to_ip >=316307720 )) and ((j.from_date <= 1740346656 and j.to_date >= 1740346656 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 126916) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316307720 and j.to_ip >=316307720 )) and ((j.from_date <= 1740346656 and j.to_date >= 1740346656 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 126916)
      550μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '3249' and is_uploaded = 1 and issue_id = 12432 order by cast(first_page as SIGNED) desc limit 1
      420μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 3249
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '3260' and is_uploaded = 1 and issue_id = 12432 order by cast(first_page as SIGNED) asc limit 1
      340μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 3260
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      160μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      170μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 126916 limit 1
      2.32msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 126916
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 25 and `b`.`banner_from_date` <= 1740346656 and `b`.`banner_to_date` >= 1740346656 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.16msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 25
      • 3: 1740346656
      • 4: 1740346656
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 25 and `b`.`banner_from_date` <= 1740346656 and `b`.`banner_to_date` >= 1740346656 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.06msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 25
      • 3: 1740346656
      • 4: 1740346656
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='9454ef163dd8f837c1593eb5394a64e9'
      190μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        kV71YkqNUODFtsjjrXN3E10OXOkN0kFFEC8PBH3p
        uc_cart_id
        9454ef163dd8f837c1593eb5394a64e9
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/126916" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/126916
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6Ilk2aDdjVjBmZ0kyUGFLYmpqRkUyTkE9PSIsInZhbHVlIjoiVG82clRiaHdyTVUyVzlhYk1CTjhrWG9FL29naURKSlBaRFpRTHNVd0VnND0iLCJtYWMiOiI3YzVkYzU1ZTc3YzUwNWU1Mjc4M2VhMjcxNDVjODlkYWViOGM0OGZiOGRmYmM5YjM1OTE3MDNlNTk2YjMyYjhjIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6Ilk2aDdjVjBmZ0kyUGFLYmpqRkUyTkE9PSIsInZhbHVlIjoiVG82clRiaHdyTVUyVzlhYk1CTjhrWG9FL29naURKSlBaRFpRTHNVd0VnND0iLCJtYWMiOiI3YzVkYzU1ZTc3YzUw" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Sun, 23 Feb 2025 21:37:36 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjAydk5mVWg1cjUvMk9ERTdmekg4dUE9PSIsInZhbHVlIjoibGpnMDBuZW1tTkZWZmJOQUFtME9BVStocmRkZXRqYUh1RDdGZVRiQkl2K3VXZEMxWlJLdkk1Z09HMlpGWmZQMHJBV0ZieWNheU01ZmxkU2NyeVM1NzZqSkIwcEZjdDRRTDVyeFBrSnhaRzFiakJPZTdmRlA3cnZtS1ErbHAwOVMiLCJtYWMiOiIyYTMxMDc2ZjQzMThhOGQxNWRlOTZkZjViNWZlYzA2MDEzYmVmNjgyY2YzYWYyMWQ2OGQ5YzNjOTQ0ZDc0NjEyIiwidGFnIjoiIn0%3D; expires=Wed, 26 Feb 2025 09:37:36 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IjAydk5mVWg1cjUvMk9ERTdmekg4dUE9PSIsInZhbHVlIjoibGpnMDBuZW1tTkZWZmJOQUFtME9BVStocmRkZXRqYUh1RDdGZVRiQkl2K3VXZEMxWlJLdkk1Z09HMlpGWmZQMHJBV0Zie" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkhIOGdEOVVjMG5QQjJ1dldwZUtIb2c9PSIsInZhbHVlIjoiQlJwcXBxb3JCZXU4YUFXblNvMmFFSkJxUUg3ay8rSXE0RGxyUXBFMUZZR3kwdHpqWktROHlHOGJnSnVDSUlUQTNnVUFWVzZ0TlR3Z3dsdS9nUlVzZS9VVHVyaGlBR2pXY2dtS1Nlcm9ZMW51SjVjb0htblpGT1d5L1lZMXlIalYiLCJtYWMiOiJhMDZiMDJhMjViNzM2MTZjYWI4MzczZmViNDlkOTIzZGIzNDBkMjA0MDczODlkYzkwYTJhZDVlMDVmYTQ0YWJlIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IkhIOGdEOVVjMG5QQjJ1dldwZUtIb2c9PSIsInZhbHVlIjoiQlJwcXBxb3JCZXU4YUFXblNvMmFFSkJxUUg3ay8rSXE0RGxyUXBFMUZZR3kwdHpqWktROHlHOGJ" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjAydk5mVWg1cjUvMk9ERTdmekg4dUE9PSIsInZhbHVlIjoibGpnMDBuZW1tTkZWZmJOQUFtME9BVStocmRkZXRqYUh1RDdGZVRiQkl2K3VXZEMxWlJLdkk1Z09HMlpGWmZQMHJBV0ZieWNheU01ZmxkU2NyeVM1NzZqSkIwcEZjdDRRTDVyeFBrSnhaRzFiakJPZTdmRlA3cnZtS1ErbHAwOVMiLCJtYWMiOiIyYTMxMDc2ZjQzMThhOGQxNWRlOTZkZjViNWZlYzA2MDEzYmVmNjgyY2YzYWYyMWQ2OGQ5YzNjOTQ0ZDc0NjEyIiwidGFnIjoiIn0%3D; expires=Wed, 26-Feb-2025 09:37:36 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IjAydk5mVWg1cjUvMk9ERTdmekg4dUE9PSIsInZhbHVlIjoibGpnMDBuZW1tTkZWZmJOQUFtME9BVStocmRkZXRqYUh1RDdGZVRiQkl2K3VXZEMxWlJLdkk1Z09HMlpGWmZQMHJBV0Zie" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkhIOGdEOVVjMG5QQjJ1dldwZUtIb2c9PSIsInZhbHVlIjoiQlJwcXBxb3JCZXU4YUFXblNvMmFFSkJxUUg3ay8rSXE0RGxyUXBFMUZZR3kwdHpqWktROHlHOGJnSnVDSUlUQTNnVUFWVzZ0TlR3Z3dsdS9nUlVzZS9VVHVyaGlBR2pXY2dtS1Nlcm9ZMW51SjVjb0htblpGT1d5L1lZMXlIalYiLCJtYWMiOiJhMDZiMDJhMjViNzM2MTZjYWI4MzczZmViNDlkOTIzZGIzNDBkMjA0MDczODlkYzkwYTJhZDVlMDVmYTQ0YWJlIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IkhIOGdEOVVjMG5QQjJ1dldwZUtIb2c9PSIsInZhbHVlIjoiQlJwcXBxb3JCZXU4YUFXblNvMmFFSkJxUUg3ay8rSXE0RGxyUXBFMUZZR3kwdHpqWktROHlHOGJ" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "kV71YkqNUODFtsjjrXN3E10OXOkN0kFFEC8PBH3p" "uc_cart_id" => "9454ef163dd8f837c1593eb5394a64e9" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/126916" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-23 21:37:36GET/article/126916514361