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Recent Advances in Drug Delivery and Formulation

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ISSN (Print): 2667-3878
ISSN (Online): 2667-3886

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Review Article

In Situ Hydrogels for Effective Treatment of Cancer: Strategies and Polymers Used

Author(s): Anshula Mehra, Abhay Tharmatt, Navdeep Saini, Gurdeep Singh, Kirandeep Kaur, Gurpreet Singh and Neena Bedi*

Volume 16, Issue 4, 2022

Published on: 21 October, 2022

Page: [287 - 308] Pages: 22

DOI: 10.2174/2667387816666221005102931

Price: $65

Abstract

Cancer is a worldwide health ailment with no known boundaries in terms of mortality and occurrence rates, thus is one of the biggest threats to humankind. Hence, there is an absolute need to develop novel therapeutics to bridge the infirmities associated with chemotherapy and conventional surgical methodologies, including impairment of normal tissue, compromised drug efficiency and an escalation in side effects. In lieu of this, there has been a surge in curiosity towards the development of injectable hydrogels for cancer therapy because local administration of the active pharmaceutical agent offers encouraging advantages such as providing a higher effective dose at the target site, a prolonged retention time of drug, ease of administration, mitigation of dose in vivo, and improved patient compliance. Furthermore, due to their biocompatible nature, such systems can significantly reduce the side effects that occur on long-term exposure to chemotherapy. The present review details the most recent advancements in the in-situ gel forming polymers (natural and synthetic), polymeric cross-linking methodologies and in-situ gelling mechanisms, focusing on their clinical benefits in cancer therapy.

Keywords: Injectable, Hydrogels, Natural polymers, Synthetic polymers, Cross-linking, Cancer

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