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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

General Review Article

Apolipoprotein-mimetic Peptides: Current and Future Prospectives

Author(s): Sunil A. Nankar, Sakeel Ahmed, Shyam Sunder Sharma and Abhay H. Pande*

Volume 23, Issue 11, 2022

Published on: 21 October, 2022

Page: [757 - 772] Pages: 16

DOI: 10.2174/1389203723666221003122624

Price: $65

Abstract

Apolipoprotein-mimetic peptides, mimicking the biological properties of apolipoproteins, have shown beneficial properties against various diseases (central and peripheral diseases) and have emerged as potential candidates for their treatments. Progress has been made from first-generation to second-generation apolipoprotein-mimetic peptides. Understanding these peptides from the first generation to the second generation is discussed in this review. First, we discussed the structural and therapeutic potentials of first-generation apolipoprotein-mimetic peptides. Further, we discussed the development of second-generation apolipoprotein-mimetic peptides, like dual-domain and bihelical peptides the emergence of second-generation apolipoprotein-mimetic peptides as potential candidates in different preclinical and clinical studies has also been emphasized.

Keywords: apolipoprotein, peptides, inflammation, CVDs, Alzheimer's disease.

Graphical Abstract


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