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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Beyond 1,2,3-triazoles: Formation and Applications of Ketemines Derived from Copper Catalyzed Azide Alkyne Cycloaddition

Author(s): Flor M. Escandón-Mancilla, Nelly González-Rivas, Murali V. Basavanag Unnamatla, Marco A. García-Eleno, David Corona-Becerril, Bernardo A. Frontana-Uribe and Erick Cuevas-Yañez*

Volume 21, Issue 4, 2024

Published on: 28 December, 2022

Page: [359 - 379] Pages: 21

DOI: 10.2174/1570179420666220929152449

Price: $65

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Abstract

Ketemines represent an interesting class of organic intermediates that has undergone a regrowth as a consequence of recent extensions of copper catalyzed azide alkyne cycloaddition (Cu- AAC) to other synthetic fields. This review summarizes the most recent generation methods of ketimines from CuAAC reaction, highlighting chemical properties focused on the synthesis of cyclic compounds, among others, affording a general outlook towards the development of new biologically active compounds.

Keywords: Ketenimine, alkyne, azide, copper catalyzed azide alkyne cycloaddition.

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Graphical Abstract

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