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Mini-Reviews in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Review Article

Chemistry of gem-Difluorovinyl Sulfonates

Author(s): Cai Zhang*

Volume 20, Issue 8, 2023

Published on: 01 November, 2022

Page: [842 - 853] Pages: 12

DOI: 10.2174/1570193X19666220929114415

Price: $65

Abstract

Among various emerging organofluorine molecules, gem-difluorovinyl sulfonates are attractive building blocks and less used in organic reactions. This review article is concerned with recent advances in organic reactions using gem-difluorovinyl sulfonates in recent years. We discussed the reactions of gem-difluorovinyl sulfonates with aldehydes, amines, imines, amides, boronic acids, aryl halides, etc. or addition, reduction, substitution and intramolecular 1,3-sulfonyl migration of gemdifluorovinyl sulfonates in nine approaches. The synthetic strategies described in this review provided diversely substituted fluorinated molecules.

Keywords: gem-difluorovinyl sulfonates, 2, 2-difluorovinyl tosylate, boronic acids, amines, indoles, alkynes.

Graphical Abstract

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