Abstract
The discoveries of the pluripotent role of glycogen synthase kinase-3 (GSK-3) are pointing to GSK-3 as a potential target for therapy of neurodegenerative disorders and type 2 diabetes. GSK-3 is a constitutively active protein kinase that is inhibited in response to various extracellular signals. Lithium has been found to be an important inhibitor of GSK-3 activity and its use as a laboratory tool has contributed to the understanding of the role of GSK-3. Fluoride has been often used in study designs on GSK-3 as the inhibitor of protein phosphatases. Potential interactions of fluoride with the observed lithium effects are discussed.
Keywords: Glycogen synthase kinase-3 (GSK-3), lithium, fluoride, aluminofluoride complexes, protein phosphatase -1
Current Enzyme Inhibition
Title: Potential Lithium and Fluoride Interactions in Studies of Glycogen Synthase Kinase-3
Volume: 4 Issue: 3
Author(s): Anna Strunecka and Jiri Patocka
Affiliation:
Keywords: Glycogen synthase kinase-3 (GSK-3), lithium, fluoride, aluminofluoride complexes, protein phosphatase -1
Abstract: The discoveries of the pluripotent role of glycogen synthase kinase-3 (GSK-3) are pointing to GSK-3 as a potential target for therapy of neurodegenerative disorders and type 2 diabetes. GSK-3 is a constitutively active protein kinase that is inhibited in response to various extracellular signals. Lithium has been found to be an important inhibitor of GSK-3 activity and its use as a laboratory tool has contributed to the understanding of the role of GSK-3. Fluoride has been often used in study designs on GSK-3 as the inhibitor of protein phosphatases. Potential interactions of fluoride with the observed lithium effects are discussed.
Export Options
About this article
Cite this article as:
Strunecka Anna and Patocka Jiri, Potential Lithium and Fluoride Interactions in Studies of Glycogen Synthase Kinase-3, Current Enzyme Inhibition 2008; 4 (3) . https://dx.doi.org/10.2174/157340808785909394
DOI https://dx.doi.org/10.2174/157340808785909394 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Differential Expression of Ribosomal Genes in Brain and Blood of Alzheimer’s Disease Patients
Current Alzheimer Research BACE1 Structure and Function in Health and Alzheimers Disease
Current Alzheimer Research Cholesterol, Alzheimers Disease, Prion Disorders: A menage a trois?
Current Drug Targets Recent Knowledge on Medicinal Plants as Source of Cholinesterase Inhibitors for the Treatment of Dementia
Mini-Reviews in Medicinal Chemistry Past, Present and Future Drugs for the Treatment of Obsessive- Compulsive Disorder
Current Medicinal Chemistry Application of Proteomic Tools in Modern Nanotechnological Approaches Towards Effective Management of Neurodegenerative Disorders
Current Drug Metabolism The Role of P-Glycoprotein in Psychiatric Disorders: A Reliable Guard of the Brain?
Central Nervous System Agents in Medicinal Chemistry Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics
Current Genomics Commentary: Multifactoriality of Amytrophic Lateral Sclerosis: Linking Unfolded Proteins to Oxidative Stress in Microglia
CNS & Neurological Disorders - Drug Targets Cucurbitacin E, An Experimental Lead Triterpenoid with Anticancer, Immunomodulatory and Novel Effects Against Degenerative Diseases. A Mini-Review
Current Topics in Medicinal Chemistry Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity
Current Medicinal Chemistry Biochemical, Molecular and Epigenetic Mechanisms of Valproic Acid Neuroprotection
Current Molecular Pharmacology Mitogenomics: Recognizing the Significance of Mitochondrial Genomic Variation for Personalized Medicine
Current Pharmacogenomics and Personalized Medicine Editorial (How Natural is it for Nature to Help with Major Depressive Disorder?)
CNS & Neurological Disorders - Drug Targets Current Experimental Therapy for Alzheimers Disease
Current Neuropharmacology Genetic Determinants of Amyotrophic Lateral Sclerosis as Therapeutic Targets
CNS & Neurological Disorders - Drug Targets Anesthesia Issues in Central Nervous System Disorders
Current Aging Science Strategies for Skeletal Muscle Targeting in Drug Discovery
Current Pharmaceutical Design The Role of 5-Hydroxymethylcytosine in Aging and Alzheimer’s Disease: Current Status and Prospects for Future Studies
Current Alzheimer Research X-ray Crystallography and Computational Docking for the Detection and Development of Protein–Ligand Interactions
Current Medicinal Chemistry