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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

Direct Vinylation of Activated Methines by a Vinylsulfonium Salt

Author(s): Chunsong Xie*, Jiahong Hu, Xiaole Zhu, Song Wu, Yujia Xu and Hongyi Ye

Volume 20, Issue 5, 2023

Published on: 15 November, 2022

Page: [389 - 394] Pages: 6

DOI: 10.2174/1570178619666220926141846

Price: $65

Abstract

Vinylation of activated methines is a synthetically useful and challenging transformation. Traditional methods for this transformation always encounter multiple steps, limited generality and/or handling gaseous substrates. Herein, we report by using diphenyl(vinyl)sulfonium triflate as a vinylation component, a one-step direct vinylation of activated methines can be realized under mild conditions. This reaction, compatible with several kinds of activated methines, can lead to the construction of vinylated quaternary carbon centers concisely.

Keywords: Vinylation, Activated methine, Vinylsulfonium, Tandem Reaction, quaternary carbon center, cascade reaction

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