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Recent Advances in Anti-Infective Drug Discovery

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ISSN (Print): 2772-4344
ISSN (Online): 2772-4352

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Review Article

Multidrug-Resistant Acinetobacter baumannii: An Emerging Aspect of New Drug Discovery

Author(s): Khushi R. Mittal, Nandini Jain, Poornima Srivastava and Chakresh Kumar Jain*

Volume 18, Issue 1, 2023

Published on: 12 October, 2022

Page: [29 - 41] Pages: 13

DOI: 10.2174/2772434417666220912120726

Price: $65

Abstract

Background: Acinetobacter baumannii is an opportunistic multidrugresistant, aerobic, glucose non-fermentative, and oxidative-negative coccobacilli bacteria. This life-threatening nosocomial infection is associated with immunocompromised patients.

Objective: This review aims to investigate the multiple drug resistance mechanisms and new emerging diagnostics & treatments for Acinetobacter baumannii.

Methods: All the articles that were most relevant to A. baumannii virulence and drug resistance mechanisms were founded by a literature search on PubMed. Google Patents were used to find discoveries related to diagnostics and treatment.

Results: Efflux pumps, β-lactamases, aminoglycosides, outer membrane proteins, and alteration of the target sites were identified in the Acinetobacter baumannii pathogen as the most prevalent drug resistance mechanisms. Gene detection, peptide detection, and antigen-antibody-associated detection were the latest diagnostics. Novel antimicrobial peptides, sterilization techniques using blue light, and combination therapies are being developed to effectively treat A. baumannii infections.

Conclusion: This review concludes that new drugs and formulations with high efficiency, low cytotoxicity, and no nephrotoxicity are in absolute need. In the near future, we can expect omics technology to play a significant role in discovering new drugs and potential targets.

Keywords: Antimicrobial resistance, Acinetobacter baumannii, Multidrug resistance, Efflux pump, β-lactamases, Aminoglycosidases, Porins, Immunocompromised patients

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