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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Sotorasib: First Approved KRAS Mutation Inhibitor for the Treatment of Non-small Cell Lung Cancer

Author(s): Surya K. De*

Volume 30, Issue 9, 2023

Published on: 30 September, 2022

Page: [1000 - 1002] Pages: 3

DOI: 10.2174/0929867329666220907161505

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[1]
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Sproat, M.R.; Hofherr, M.L.; Devarakonda, S. Successful use of sotorasib in a patient with end stage renal disease on dialysis with metastatic lung adenocarcinoma: A case report. Clin. Lung Cancer, 2022, 23(6), E339-E341.
[http://dx.doi.org/10.1016/j.cllc.2022.04.007]
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[http://dx.doi.org/10.1016/j.tips.2022.03.011] [PMID: 35461718]
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Skoulidis, F.; Li, B.T.; Dy, G.K.; Price, T.J.; Falchook, G.S.; Wolf, J.; Italiano, A.; Schuler, M.; Borghaei, H.; Barlesi, F.; Kato, T.; Curioni-Fontecedro, A.; Sacher, A.; Spira, A.; Ramalingam, S.S.; Takahashi, T.; Besse, B.; Anderson, A.; Ang, A.; Tran, Q.; Mather, O.; Henary, H.; Ngarmchamnanrith, G.; Friberg, G.; Velcheti, V.; Govindan, R. Sotorasib for lung cancers with KRAS p.G12C mutation. N. Engl. J. Med., 2021, 384(25), 2371-2381.
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Awad, M.M.; Liu, S.; Rybkin, I.I.; Arbour, K.C.; Dilly, J.; Zhu, V.W.; Johnson, M.L.; Heist, R.S.; Patil, T.; Riely, G.J.; Jacobson, J.O.; Yang, X.; Persky, N.S.; Root, D.E.; Lowder, K.E.; Feng, H.; Zhang, S.S.; Haigis, K.M.; Hung, Y.P.; Sholl, L.M.; Wolpin, B.M.; Wiese, J.; Christiansen, J.; Lee, J.; Schrock, A.B.; Lim, L.P.; Garg, K.; Li, M.; Engstrom, L.D.; Waters, L.; Lawson, J.D.; Olson, P.; Lito, P.; Ou, S.H.I.; Christensen, J.G.; Jänne, P.A.; Aguirre, A.J. Acquired resistance to KRAS G12C inhibition in cancer. N. Engl. J. Med., 2021, 384(25), 2382-2393.
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Fakih, M.G.; Kopetz, S.; Kuboki, Y.; Kim, T.W.; Munster, P.N.; Krauss, J.C.; Falchook, G.S.; Han, S.W.; Heinemann, V.; Muro, K.; Strickler, J.H.; Hong, D.S.; Denlinger, C.S.; Girotto, G.; Lee, M.A.; Henary, H.; Tran, Q.; Park, J.K.; Ngarmchamnanrith, G.; Prenen, H.; Price, T.J. Sotorasib for previously treated colorectal cancers with KRASG12C mutation (CodeBreaK100): A prespecified analysis of a single-arm, phase 2 trial. Lancet Oncol., 2022, 23(1), 115-124.
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Li, J.X.; Li, R.Z.; Ma, L.R.; Wang, P.; Xu, D.H.; Huang, J.; Li, L.Q.; Tang, L.; Xie, Y.; Leung, E.L.H.; Yan, P.Y. Targeting mutant kirsten rat sarcoma viral oncogene homolog in non-small cell lung cancer: Current difficulties, integrative treatments and future perspectives. Front. Pharmacol., 2022, 13, 875330.
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Haider, K.; Sharma, A.; Yar, M.S.; Yakkala, P.A.; Shafi, S.; Kamal, A. Novel approaches for the development of direct KRAS inhibitors: Structural insights and drug design. Expert Opin. Drug Discov., 2022, 17(3), 247-257.
[http://dx.doi.org/10.1080/17460441.2022.2029842] [PMID: 35084268]
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Rohatgi, A.; Govindan, R. Targeting KRAS G12C mutation in lung adenocarcinoma. Lung Cancer, 2022, 165, 28-33.
[http://dx.doi.org/10.1016/j.lungcan.2021.12.021] [PMID: 35066360]
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Kwan, A.K.; Piazza, G.A.; Keeton, A.B.; Leite, C.A. The path to the clinic: A comprehensive review on direct KRASG12C inhibitors. J. Exp. Clin. Cancer Res., 2022, 41(1), 27.
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[http://dx.doi.org/10.1158/2159-8290.CD-19-1167] [PMID: 31658955]
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[http://dx.doi.org/10.1016/j.critrevonc.2021.103524] [PMID: 34800654]

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