Login Register Cart 0
Generic placeholder image

Recent Advances in Anti-Infective Drug Discovery

Editor-in-Chief

ISSN (Print): 2772-4344
ISSN (Online): 2772-4352

Back
Journal Home About Journal Editorial Board Current Issue Volumes/Issues
Subscribe
Research Article

Triggers for Acceptance of COVID-19 Vaccination: A Community- Based Study

Author(s): Mohammed A. Medhat, Mohamed O. Nour, Ahmed Yousef, Fathiya El-Raey, Heba Aly, Sherief Mousa, Nahed A Makhlouf, Mohamed El Badry, Amin Abdel Baki, Maysaa A. Saeed, Sherief Abd-Elsalam*, Esssam A. Hassan, Shaker Wagih Shaltout, Hanaa Kh. Fathelbab and Samy Zaky

Volume 18, Issue 1, 2023

Published on: 17 October, 2022

Page: [54 - 68] Pages: 15

DOI: 10.2174/2772434417666220907151635

Price: $65

Abstract

Background: COVID- 19 vaccines have been released, giving a major hope of getting rid of the dark pandemic crisis. The availability of vaccines does not necessarily mean that the mass vaccination program is a success. We aimed to investigate COVID-19 vaccination knowledge level, acceptance rate, and perception state among Egyptians.

Methods: An analytical cross-sectional online survey was carried out utilizing a selfadministered adult questionnaire that assesses vaccination acceptance with related sociodemographic factors and perceptions based on health belief model perspectives. Predictors of vaccination acceptance were based on logistic regression analysis.

Results: We analyzed data for 957 participants, aged 18–78 years, 55.7% were females, and 66.9% were healthcare workers (HCWs). About one-fourth had a history of confirmed COVID-19 infection and 56.5% would accept to have one of the COVID-19 vaccines, where “Pfizer” was the preferable one (37.8%), while “AstraZeneca” was the most rejected vaccine (26.8%). The 1st vaccine dose was received by 273 (28.5%) of which 260 were intended to receive the 2nd dose. Vaccine efficacy, side effects, protection time, and administration route were essentially among the factors that may influence their decision to accept COVID-19 vaccines. About 83.1% had good knowledge about vaccination which was significantly higher with increased age, among graduates/professionals, governmental workers, HCWs in addition to those able to save/invest money, had a history of confirmed COVID-19 infection and intending to have COVID-19 vaccine. Perceptions that vaccination decreases the chance of getting COVID-19 or its complications (OR = 9.28; CI: 5.03-17.12), vaccination makes less worry about catching COVID-19 (OR = 6.76; CI: 3.88-11.76), and being afraid of getting COVID-19 (OR = 2.04; CI: 1.26–3.31) were strong significant predictors for vaccine acceptance.

Conclusion: Vaccine campaigns should emphasize vaccine benefits and highlight the severity of infection while addressing barriers to vaccination in order to improve vaccine coverage among populations.

Keywords: COVID-19, Vaccine, Knowledge, Acceptance, Barriers, Perception

« Previous Next »
Graphical Abstract

[1]
Eurosurveillance editorial team. Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern. Euro Surveill 2020; 25(5): 200131.
[http://dx.doi.org/10.2807/1560-7917.ES.2020.25.5.200131e]
[2]
Gates B. Responding to Covid-19 - A once-in-a-century pandemic? N Engl J Med 2020; 382(18): 1677-9.
[http://dx.doi.org/10.1056/NEJMp2003762] [PMID: 32109012]
[3]
World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard. 2022. Available at: https://covid19.who.int/ (Accessed on: June 29, 2021).
[4]
World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard: Egypt. 2022. Available at: https://covid19.who.int/region/emro/country/eg (Accessed on: June 29, 2021).
[5]
Kennedy A, LaVail K, Nowak G, Basket M, Landry S. Confidence about vaccines in the United States: understanding parents’ perceptions. Health Aff 2011; 30(6): 1151-9.
[http://dx.doi.org/10.1377/hlthaff.2011.0396] [PMID: 21653969]
[6]
Mellet J, Pepper MS. A COVID-19 vaccine: Big strides come with big challenges. Vaccines 2021; 9(1): 39.
[http://dx.doi.org/10.3390/vaccines9010039] [PMID: 33440895]
[7]
Sallam M, Dababseh D, Eid H, et al. Low COVID-19 vaccine acceptance is correlated with conspiracy beliefs among university students in Jordan. Int J Environ Res Public Health 2021; 18(5): 2407.
[http://dx.doi.org/10.3390/ijerph18052407] [PMID: 33804558]
[8]
de Figueiredo A, Simas C, Karafillakis E, Paterson P, Larson HJ. Mapping global trends in vaccine confidence and investigating barriers to vaccine uptake: A large-scale retrospective temporal modelling study. Lancet 2020; 396(10255): 898-908.
[http://dx.doi.org/10.1016/S0140-6736(20)31558-0] [PMID: 32919524]
[9]
Baumgaertner B, Ridenhour BJ, Justwan F, Carlisle JE, Miller CR. Risk of disease and willingness to vaccinate in the United States: A population-based survey. PLoS Med 2020; 17(10): e1003354.
[http://dx.doi.org/10.1371/journal.pmed.1003354] [PMID: 33057373]
[10]
Neumann-Böhme S, Varghese NE, Sabat I, et al. Once we have it, will we use it? A European survey on willingness to be vaccinated against COVID-19. Eur J Health Econ 2020; 21(7): 977-82.
[http://dx.doi.org/10.1007/s10198-020-01208-6] [PMID: 32591957]
[11]
Reiter PL, Pennell ML, Katz ML. Acceptability of a COVID-19 vaccine among adults in the United States: How many people would get vaccinated? Vaccine 2020; 38(42): 6500-7.
[http://dx.doi.org/10.1016/j.vaccine.2020.08.043] [PMID: 32863069]
[12]
Rosenstock IM, Strecher VJ, Becker MH. Social learning theory and the health belief model. Health Educ Q 1988; 15(2): 175-83.
[http://dx.doi.org/10.1177/109019818801500203] [PMID: 3378902]
[13]
Yang ZJ. Predicting young adults’ intentions to get the H1N1 vaccine: An integrated model. J Health Commun 2015; 20(1): 69-79.
[http://dx.doi.org/10.1080/10810730.2014.904023] [PMID: 24870976]
[14]
Shahrabani S, Benzion U, Yom Din G. Factors affecting nurses’ decision to get the flu vaccine. Eur J Health Econ 2009; 10(2): 227-31.
[http://dx.doi.org/10.1007/s10198-008-0124-3] [PMID: 18781347]
[15]
Larson HJ. The biggest pandemic risk? Viral misinformation. Nature 2018; 562(7727): 309.
[http://dx.doi.org/10.1038/d41586-018-07034-4] [PMID: 30327527]
[16]
García-Montero C, Fraile-Martínez O, Bravo C, et al. An updated review of SARS-CoV-2 vaccines and the importance of effective vaccination programs in pandemic times. Vaccines 2021; 9(5): 433.
[http://dx.doi.org/10.3390/vaccines9050433] [PMID: 33925526]
[17]
Pai SM, Othman AA, Rusch L, et al. Science and evidence-based review and approval of COVID-19 vaccines: A statement of support for the US FDA. J Clin Pharmacol 2021; 61(3): 277-9.
[http://dx.doi.org/10.1002/jcph.1794] [PMID: 33274473]
[18]
Lazarus JV, Ratzan SC, Palayew A, et al. A global survey of potential acceptance of a COVID-19 vaccine. Nat Med 2021; 27(2): 225-8.
[http://dx.doi.org/10.1038/s41591-020-1124-9] [PMID: 33082575]
[19]
Chirumbolo S. Vaccination hesitancy and the “myth” on mRNA‐based vaccines in Italy in the COVID‐19 era: Does urgency meet major safety criteria? J Med Virol 2021; 93(7): 4049-53.
[http://dx.doi.org/10.1002/jmv.26922] [PMID: 33666240]
[20]
Wilson K. Nguyen, Holdt H, Brehaut JC, Hoe E. Acceptance of a pandemic influenza vaccine: A systematic review of surveys of the general public. Infect Drug Resist 2011; 4: 197-207.
[http://dx.doi.org/10.2147/IDR.S23174] [PMID: 22114512]
[21]
Kreps S, Prasad S, Brownstein JS, et al. Factors associated with US adults’ likelihood of accepting COVID-19 vaccination. JAMA Netw Open 2020; 3(10): e2025594.
[http://dx.doi.org/10.1001/jamanetworkopen.2020.25594] [PMID: 33079199]
[22]
Gallè F, Sabella EA, Roma P, et al. Knowledge and acceptance of COVID-19 vaccination among undergraduate students from Central and Southern Italy. Vaccines 2021; 9(6): 638.
[http://dx.doi.org/10.3390/vaccines9060638] [PMID: 34200835]
[23]
Levkovich I, Shinan-Altman S. The impact of gender on emotional reactions, perceived susceptibility and perceived knowledge about COVID-19 among the Israeli public. Int Health 2021; 13(6): 555-61.
[http://dx.doi.org/10.1093/inthealth/ihaa101] [PMID: 33449111]
[24]
Biasio LR, Bonaccorsi G, Lorini C, Mazzini D, Pecorelli S. Italian adults’ likelihood of getting a COVID-19 vaccine: A second online survey. Vaccines 2021; 9(3): 268.
[http://dx.doi.org/10.3390/vaccines9030268] [PMID: 33802873]
[25]
Glanz K, Rimer BK, Viswanath K, Eds. Health behavior and health education: Theory, research, and practice. John Wiley & Sons 2008.
[26]
Becker MH, Maiman LA, Kirscht JP, Haefner DP, Drachman RH. The health belief model and prediction of dietary compliance: A field experiment. J Health Soc Behav 1977; 18(4): 348-66.
[http://dx.doi.org/10.2307/2955344] [PMID: 617639]
[27]
Schwarzinger M, Flicoteaux R, Cortarenoda S, Obadia Y, Moatti JP. Low acceptability of A/H1N1 pandemic vaccination in French adult population: Did public health policy fuel public dissonance? PLoS One 2010; 5(4): e10199.
[http://dx.doi.org/10.1371/journal.pone.0010199] [PMID: 20421908]
[28]
Wang Q, Yue N, Zheng M, et al. Influenza vaccination coverage of population and the factors influencing influenza vaccination in mainland China: A meta-analysis. Vaccine 2018; 36(48): 7262-9.
[http://dx.doi.org/10.1016/j.vaccine.2018.10.045] [PMID: 30340886]
[29]
Wang J, Lu X, Lai X, et al. The changing acceptance of COVID-19 vaccination in different epidemic phases in China: A longitudinal study. Vaccines 2021; 9(3): 191.
[http://dx.doi.org/10.3390/vaccines9030191] [PMID: 33668923]
[30]
Wang J, Jing R, Lai X, et al. Acceptance of COVID-19 vaccination during the COVID-19 pandemic in China. Vaccines 2020; 8(3): 482.
[http://dx.doi.org/10.3390/vaccines8030482] [PMID: 32867224]
[31]
Larson HJ, Jarrett C, Eckersberger E, Smith DMD, Paterson P. Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: A systematic review of published literature, 2007–2012. Vaccine 2014; 32(19): 2150-9.
[http://dx.doi.org/10.1016/j.vaccine.2014.01.081] [PMID: 24598724]
[32]
Barello S, Nania T, Dellafiore F, Graffigna G, Caruso R. ‘Vaccine hesitancy’ among university students in Italy during the COVID-19 pandemic. Eur J Epidemiol 2020; 35(8): 781-3.
[http://dx.doi.org/10.1007/s10654-020-00670-z] [PMID: 32761440]
[33]
Mullard A. COVID-19 vaccine development pipeline gears up. Lancet 2020; 395(10239): 1751-2.
[http://dx.doi.org/10.1016/S0140-6736(20)31252-6] [PMID: 32505245]
[34]
Larson HJ, Cooper LZ, Eskola J, Katz SL, Ratzan S. Addressing the vaccine confidence gap. Lancet 2011; 378(9790): 526-35.
[http://dx.doi.org/10.1016/S0140-6736(11)60678-8] [PMID: 21664679]
[35]
Reno C, Maietti E, Fantini MP, et al. Enhancing COVID-19 vaccine acceptance: Results from a survey on vaccine hesitancy in Northern Italy. Vaccines 2021; 9(4): 378.
[http://dx.doi.org/10.3390/vaccines9040378] [PMID: 33924534]
[36]
David M. Valuing Health care: costs, benefits, and effectiveness of pharmaceuticals and other medical technologies. J Policy Analysis Manag 1996; Vol. 15(3): 273.
[http://dx.doi.org/10.1002/pam.4050150323]
[37]
Lin Y, Hu Z, Zhao Q, Alias H, Danaee M, Wong LP. Understanding COVID-19 vaccine demand and hesitancy: A nationwide online survey in China. PLoS Negl Trop Dis 2020; 14(12): e0008961.
[http://dx.doi.org/10.1371/journal.pntd.0008961] [PMID: 33332359]
[38]
MacDonald NE. Vaccine hesitancy: Definition, scope and determinants. Vaccine 2015; 33(34): 4161-4.
[http://dx.doi.org/10.1016/j.vaccine.2015.04.036] [PMID: 25896383]
[39]
Abdelhafiz AS, Mohammed Z, Ibrahim ME, et al. Knowledge, perceptions, and attitude of Egyptians towards the novel coronavirus disease (COVID-19). J Community Health 2020; 45(5): 881-90.
[http://dx.doi.org/10.1007/s10900-020-00827-7] [PMID: 32318986]
[40]
Application of health belief model to assess COVID-19 vaccine acceptance: A population-based survey. Egypt J Community Med 2022; 40(3): 173-80.
[41]
Wong LP, Alias H, Wong PF, Lee HY, AbuBakar S. The use of the health belief model to assess predictors of intent to receive the COVID-19 vaccine and willingness to pay. Hum Vaccin Immunother 2020; 16(9): 2204-14.
[http://dx.doi.org/10.1080/21645515.2020.1790279] [PMID: 32730103]
[42]
Alobaidi S. Predictors of intent to receive the COVID-19 vaccination among the population in the Kingdom of Saudi Arabia: A survey study. J Multidiscip Healthc 2021; 14: 1119-28.
[http://dx.doi.org/10.2147/JMDH.S306654] [PMID: 34040382]

Rights & Permissions Print Cite
Article Metrics
1
© 2024 Bentham Science Publishers | Privacy Policy