Synthesis of New Thiazolidinones and Thiazoles in Indole Series

Sofiane      Khanoussi; Abdelmadjid      Benmohammed; Omar      Khoumeri; Mokhtaria      Kadiri; Ayada      Djafri; Thierry      Terme; Patrice      Vanelle

doi:10.2174/1570178619666220827152700

Abstract

Recent findings confirm that thiosemicarbazones and thiazoles offer a wide range of biological properties. We report here the synthesis of two series of highly functionalized thiazole-derived compounds from the reactions of various indole-derived thiosemicarbazones with diethyl acetylenedicarboxylate and 4-bromophenacyl bromide. As a result, a series of new derivatives of thiosemicarbazone, thiazolidinone, and thiazole bearing an indole moiety was synthesized and developed in good yields.

Keywords: thiosemicarbazone, thiazolidinone, thiazole, indole, condensation, cyclization.

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DOI https://dx.doi.org/10.2174/1570178619666220827152700	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255

Letters in Organic Chemistry

Synthesis of New Thiazolidinones and Thiazoles in Indole Series

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