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Current Drug Targets

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ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

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Mini-Review Article

Elabela Peptide: An Emerging Target in Therapeutics

Author(s): Maneesha Sharma, Kedar S. Prabhavalkar and Lokesh Kumar Bhatt*

Volume 23, Issue 14, 2022

Published on: 15 September, 2022

Page: [1304 - 1318] Pages: 15

DOI: 10.2174/1389450123666220826160123

Price: $65

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Abstract

Elabela, a bioactive micropeptide, is recognized as the second endogenous ligand for the Apelin receptor and is widely distributed in different tissues and organs. Elabela plays an important role in various physiological processes, such as blood pressure control, heart morphogenesis, apoptosis, angiogenesis, cell proliferation, migration, etc. Elabela is also implicated in pathological conditions, like cardiac dysfunctions, heart failure, hypertension, kidney diseases, cancer and CNS disorders. The association of Elabela with these disease conditions makes it a potential target for their therapy. This review summarizes the physiological role of Elabela peptide as well as its implication in various disease conditions.

Keywords: Elabela, APJ receptor, Cardiovascular diseases, Kidney diseases, Cancer, CNS diseases.

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Graphical Abstract

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