Opinion: “High-Dose Immunosuppression to Prevent Death after Paraquat Self-Poisoning”- Under Estimation of a Significant Effect with Small Mortality Rate Reduction

Title:Opinion: “High-Dose Immunosuppression to Prevent Death after Paraquat Self-Poisoning”- Under Estimation of a Significant Effect with Small Mortality Rate Reduction

Volume: 19 Issue: 3

Author(s): Bita Anvari*

Affiliation:

• Department of Internal Medicine, Kermanshah University of Medical Sciences, School of Medicine, Imam Khomeini Hospital, Kermanshah, Iran

Keywords: Paraquat, toxicity, immunosuppression, intoxication, Treatment, Management

Abstract: A randomised double blinded clinical trial about high dose immunosuppression in Paraquat self-poisoning was published by Professor I. Gawaramanna et al. Before their research, it seems that a little overestimation might be present in the small previous non-randomised clinical trials. This new valuable work clarified the previous exaggerated favourable response to immunosuppression in paraquat self-poisoning; however, their analysis underestimated the favourable response to high dose immunosuppression. According to their results, high dose immunosuppression could decrease mortality considering serum paraquat level and effect time of immunosuppressive drugs but the opposite is concluded. They did not mention the impact of incomplete sample size on their results. Severe paraquat self-poisoning seems to be unresponsive to any treatment and these patients should be analyzed separately according to serum paraquat level. So after reanalysis of their results, the findings seem to be in favour of immunosuppression benefit in paraquat-self poisoning.

Cite this article as:

Anvari Bita*, Opinion: “High-Dose Immunosuppression to Prevent Death after Paraquat Self-Poisoning”- Under Estimation of a Significant Effect with Small Mortality Rate Reduction, Current Rheumatology Reviews 2023; 19 (3) . https://dx.doi.org/10.2174/1573397118666220823155018

DOI https://dx.doi.org/10.2174/1573397118666220823155018	Print ISSN 1573-3971
Publisher Name Bentham Science Publisher	Online ISSN 1875-6360