Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Editorial

Hesperidin Methyl Chalcone: An Emerging Compound for the Treatment of Inflammation and Pain

Author(s): Sergio Marques Borghi*, Rubia Casagrande and Waldiceu Aparecido Verri

Volume 30, Issue 5, 2023

Published on: 27 September, 2022

Page: [601 - 603] Pages: 3

DOI: 10.2174/0929867329666220822113459

conference banner
[1]
Fathiazad, F.; Afshar, J. An investigation on methylation methods of hesperidin. Daru, 2004, 12(1), 67-70.
[2]
Walle, T. Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption. Mol. Pharm., 2007, 4(6), 826-832.
[http://dx.doi.org/10.1021/mp700071d] [PMID: 17958394]
[3]
Pinho-Ribeiro, F.A.; Hohmann, M.S.; Borghi, S.M.; Zarpelon, A.C.; Guazelli, C.F.; Manchope, M.F.; Casagrande, R.; Verri, W.A., Jr Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-κB. Chem. Biol. Interact., 2015, 228, 88-99.
[http://dx.doi.org/10.1016/j.cbi.2015.01.011] [PMID: 25617481]
[4]
Koirala, N.; Thuan, N.H.; Ghimire, G.P.; Thang, D.V.; Sohng, J.K. Methylation of flavonoids: Chemical structures, bioactivities, progress and perspectives for biotechnological production. Enzyme Microb. Technol., 2016, 86, 103-116.
[http://dx.doi.org/10.1016/j.enzmictec.2016.02.003] [PMID: 26992799]
[5]
Gastillo, J.; Benavente, O.; Borrego, F. Analysis of commercial hesperidin methylchlcone by high performance liquid chromatography. J. Chromatogr. A, 1991, 555, 285-290.
[http://dx.doi.org/10.1016/S0021-9673(01)87191-0]
[6]
Martinez, R.M.; Pinho-Ribeiro, F.A.; Steffen, V.S.; Caviglione, C.V.; Pala, D.; Baracat, M.M.; Georgetti, S.R.; Verri, W.A.; Casagrande, R. Topical formulation containing hesperidin methyl chalcone inhibits skin oxidative stress and inflammation induced by ultraviolet B irradiation. Photochem. Photobiol. Sci., 2016, 15(4), 554-563.
[http://dx.doi.org/10.1039/C5PP00467E] [PMID: 27021784]
[7]
Ruiz-Miyazawa, K.W.; Pinho-Ribeiro, F.A.; Borghi, S.M.; Staurengo-Ferrari, L.; Fattori, V.; Amaral, F.A.; Teixeira, M.M.; Alves-Filho, J.C.; Cunha, T.M.; Cunha, F.Q.; Casagrande, R.; Verri, W.A. Jr. Hesperidin methylchalcone suppresses experimental gout arthritis in mice by inhibiting NF-κB activation. J. Agric. Food Chem., 2018, 66(25), 6269-6280.
[http://dx.doi.org/10.1021/acs.jafc.8b00959] [PMID: 29852732]
[8]
Monjotin, N.; Tenca, G. Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells. Microvasc. Res., 2022, 139, 104274.
[http://dx.doi.org/10.1016/j.mvr.2021.104274] [PMID: 34717967]
[9]
Allaert, F.A.; Hugue, C.; Cazaubon, M.; Renaudin, J.M.; Clavel, T.; Escourrou, P. Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort). Int. Angiol., 2011, 30(3), 272-277.
[PMID: 21617611]
[10]
Boyle, P.; Diehm, C.; Robertson, C. Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency. Int. Angiol., 2003, 22(3), 250-262.
[PMID: 14612852]
[11]
Martinez, R.M.; Pinho-Ribeiro, F.A.; Steffen, V.S.; Caviglione, C.V.; Vignoli, J.A.; Baracat, M.M.; Georgetti, S.R.; Verri, W.A., Jr; Casagrande, R. Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage. J. Photochem. Photobiol. B, 2015, 148, 145-153.
[http://dx.doi.org/10.1016/j.jphotobiol.2015.03.030] [PMID: 25916506]
[12]
Rasquel-Oliveira, F.S.; Manchope, M.F.; Staurengo-Ferrari, L.; Ferraz, C.R.; Saraiva-Santos, T.; Zaninelli, T.H.; Fattori, V.; Artero, N.A.; Badaro-Garcia, S.; de Freitas, A.; Casagrande, R.; Verri, W.A. Jr Hesperidin methyl chalcone interacts with NFκB Ser276 and inhibits zymosan-induced joint pain and inflammation, and RAW 264.7 macrophage activation. Inflammopharmacology, 2020, 28(4), 979-992.
[http://dx.doi.org/10.1007/s10787-020-00686-7] [PMID: 32048121]
[13]
Guazelli, C.F.S.; Fattori, V.; Ferraz, C.R.; Borghi, S.M.; Casagrande, R.; Baracat, M.M.; Verri, W.A., Jr Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis. Chem. Biol. Interact., 2021, 333, 109315.
[http://dx.doi.org/10.1016/j.cbi.2020.109315] [PMID: 33171134]
[14]
Parhiz, H.; Roohbakhsh, A.; Soltani, F.; Rezaee, R.; Iranshahi, M. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: An updated review of their molecular mechanisms and experimental models. Phytother. Res., 2015, 29(3), 323-331.
[http://dx.doi.org/10.1002/ptr.5256] [PMID: 25394264]

© 2024 Bentham Science Publishers | Privacy Policy