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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Nanogel-based Transdermal Drug Delivery System: A Therapeutic Strategy with Under Discussed Potential

Author(s): Lubna Tariq, Azher Arafah, Shafat Ali, Saba Beigh, Mashooq Ahmad Dar, Tanvir ul Hassan Dar, Aqib Iqbal Dar, Rana M. Alsaffar, Mubashir Hussain Masoodi and Muneeb U. Rehman*

Volume 23, Issue 1, 2023

Published on: 14 October, 2022

Page: [44 - 61] Pages: 18

DOI: 10.2174/1568026622666220818112728

Price: $65

Abstract

The application of nanoparticles in medication delivery has revolutionized the field of therapeutic biology. To improve medical efficacy, currently, drug nanocarriers are employed to control the release and stability, expand its circulation time, or protect it from cell clearance or premature breakdown. A crosslinked polymeric framework is used to crosslink the hydrogel nanoparticle dispersions for safer and stable delivery on target sites. Nanogels have developed in the last two decades as potential biomaterials with a wide variety of applications. Later attributes of nanogels are mainly due to large surface areas, retention of molecules, size flexibility, and water-based formulations that have made them popular as drug delivery vehicles, as seen by several in vivo uses. The gel matrix containing the nanoparticle drug demonstrated a considerable increase in drug penetration in transdermal drug and topical delivery methods. This review aims to understand why and how nanogels are considered so innovative as a drug delivery method. It also examines their preparation methods and applications in the pharmaceutical and biomedical fields and discusses the benefits of nanogels, including swelling capacity and stimulus stimuli sensitivity. Nanogels, on the other hand, have recently been investigated for applications outside the field of biomedicine. Since there are many possible uses for nanogels, we have comprehensively reviewed the current state of the art for all feasible nanogel applications and manufacturing methods.

Keywords: Nanotechnology, Nanogels, Hydrogels, Transdermal drug delivery system, Gel matrix, Therapeutics

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