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Letters in Drug Design & Discovery

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ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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Research Article

Anti-cancerous Properties of the Synthesized Substituted Chromene Compounds and their Pharmacological Activities

Author(s): Ashraf Hassan Fekry Abdelwahab* and Salma Ashraf Hassan Fekry

Volume 20, Issue 8, 2023

Published on: 27 September, 2022

Page: [1098 - 1106] Pages: 9

DOI: 10.2174/1570180819666220811102040

Price: $65

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Abstract

Introduction: 2-Amino-7-hydroxy-4-phenyl-4H-chromene-3-carbonitrile (4) was synthesized through a three-component reaction in ethanol/piperidine solution.

Methods: Synthesis of several new 4H-chromenes (5-14) has been achieved involving various reactions. The structure of these new compounds was confirmed using IR, 1H NMR and 13C NMR, as well as MS spectroscopy.

Results and Conclusion: All newly substituted chromene derivatives displayed potential analgesic and anticonvulsant activities. The structure-activity relationship study revealed that 2-amino-4-phenyl-3-(1Htetrazol- 5-yl)-4H-chromen-7-ol (13) was more beneficial than 8-hydroxy-2-methyl-5-phenyl-3,5-dihydro- 4H-chromeno[2,3-d]pyrimidin-4-one (11), 8-hydroxy-2,5-diphenyl-3,5-dihydro-4H-chromeno[2,3-d]pyrimidin- 4-one (12), and 8-hydroxy-5-phenyl-3,5-dihydro-4H-chromeno[2,3-d]pyrimidin-4-one (14) in terms of analgesic and anti-inflammatory activities.

Keywords: Analgesic, resorcinol, benzaldehyde, hydrazine hydrate, aromatic aldehydes, anti-inflammatory activity.

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Graphical Abstract

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