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Current Organocatalysis

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ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

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Research Article

A Novel Idea of Sulfamic Acid as an Efficient Catalyst for the Synthesis of 2-Azapyrrolizidine Derivatives

Author(s): Radia Tafer*, Raouf Boulcina and Abdelmadjid Debache

Volume 10, Issue 1, 2023

Published on: 22 February, 2023

Page: [19 - 25] Pages: 7

DOI: 10.2174/2213337209666220728114131

Price: $65

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Abstract

Background: The synthesis of 2-azapyrrolizidine scaffolds has fascinated scientists due to their potential biological activities.

Objective: An efficient and environmentally sustainable synthetic method has been presented to synthesize structurally various 2-azapyrrolizidines via a three-component reaction.

Methods: The condensation of aldehydes, hydantoin, and malononitrile in the presence of green and sustainable sulfamic acid as catalyst in mild conditions has been achieved.

Results: The present protocol leads, in most cases, to the desired products in high yields.

Conclusion: The synthetic efficiency and operational simplicity make the present procedure cost effective, time efficient and eco-friendly for the synthesis of substituted 2-azapyrrolizidines.

Keywords: Multicomponent reactions, One-pot synthesis, Homogeneous catalysis, Hydantoin, 2-Azapyrrolizidines, Sulfamic acid.

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