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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Perspective

The Complex Relationship Between Diabetes and Cardiac Arrhythmias: Pathophysiology and Mechanisms

Author(s): Michael Spartalis*, Panteleimon Pantelidis, Christos Kontogiannis, Stavroula A. Paschou, Eleftherios Spartalis, Dimitrios C. Iliopoulos and Gerasimos Siasos

Volume 28, Issue 26, 2022

Published on: 01 August, 2022

Page: [2129 - 2130] Pages: 2

DOI: 10.2174/1381612828666220720095433

Abstract

Coronary artery disease, autonomic neuropathy, and diabetic cardiomyopathy are the most common cardiovascular complications of diabetes. However, emerging evidence demonstrates that diabetes also affects the heart’s electrical conduction system, culminating in lethal arrhythmias and sudden cardiac death. Diabetes and rhythm disturbances have a complex relationship, and arrhythmias cannot only be attributed to ischemia and autonomic neuropathy. Hypoglycemia, hyperglycemia, and glucose fluctuations can potentially induce arrhythmias by activating various pathways. Structural remodeling can accelerate and exacerbate disease development. Mitochondrial dysfunction can also alter the structure and metabolism of cardiomyocytes and contribute to disease progression through oxidative stress and inflammation.

Keywords: Diabetes mellitus, arrhythmias, cardiovascular, sudden cardiac death, fibrosis, substrate.

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