Expanding the Chemical Space in Practice: Diversity-Oriented Synthesis

Marine      Peuchmaur; Yung-Sing      Wong

doi:10.2174/138620708785739916

Abstract

Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported.

Keywords: Diversity-Oriented Synthesis, small molecules, complexity, diversity, multicomponent reactions, stereodivergent reactions, skeletal divergent reactions, chemical space

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Combinatorial Chemistry & High Throughput Screening

Title: Expanding the Chemical Space in Practice: Diversity-Oriented Synthesis

Volume: 11 Issue: 8

Author(s): Marine Peuchmaur and Yung-Sing Wong

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Keywords: Diversity-Oriented Synthesis, small molecules, complexity, diversity, multicomponent reactions, stereodivergent reactions, skeletal divergent reactions, chemical space

Abstract: Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported.

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Peuchmaur Marine and Wong Yung-Sing, Expanding the Chemical Space in Practice: Diversity-Oriented Synthesis, Combinatorial Chemistry & High Throughput Screening 2008; 11 (8) . https://dx.doi.org/10.2174/138620708785739916