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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

Correlation Between Vitamin B12 Deficiency and Autoimmune Thyroid Diseases

Author(s): Tinatin Kacharava*, Elene Giorgadze, Shota Janjgava, Nino Lomtadze and Iamze Taboridze

Volume 23, Issue 1, 2023

Published on: 27 September, 2022

Page: [86 - 94] Pages: 9

DOI: 10.2174/1871530322666220627145635

Price: $65

Abstract

Background: Autoimmune thyroid diseases (AITD) are the most prevalent organ-specific autoimmune disorders. Vitamin B12 plays an important role in the proper functioning of the immune system. The aim of this study was therefore to investigate the correlation between vitamin B12 deficiency and AITD.

Materials and Methods: A total of 306 patients (aged 18-65 years, mean – 37.6 ± 11.3 years and comprising 87 males and 219 females) were studied retrospectively (observational study). Patients were divided into groups: with and without vitamin B12 deficiency, and with and without AITD. Differences between groups were evaluated by Fisher’s exact test for qualitative variables and by Student’s t-test for quantitative variables. Correlations for quantitative factors were determined by the Pearson correlation coefficient and for qualitative factors by Spearman correlation analysis. The sensitivity and specificity of vitamin B12 deficiency for AITD were calculated by ROC analysis.

Results: The vitamin B12 level was significantly lower in patients with AITD (and 200.70 + 108.84) compared to controls (393.41+150.78 p<0.0001). Patients with vitamin B12 deficiency were characterized by significantly higher mean values of anti-TPO (236.60+455.74) compared to controls (39.51+165.57 p<0.0001). Vitamin B12 levels were inversely correlated to anti-TPO levels (r=– 0.233, p<0.001). Roc analysis of vitamin B12 as a diagnostic test for AITD gave the area under curve as 0.881 (95% CI: 0.839-0.924), a sensitivity of – 0.947, a specificity of – 0.768, and a cutoff value of – 178.9.

Conclusion: The vitamin B12 level correlates significantly to AITD. The concentration of vitamin B12 should therefore be determined in patients with autoimmune thyroiditis as a diagnostic test with high sensitivity and good specificity.

Keywords: B12 vitamin, AITD, thyroiditis, autoimmune, correlation, immune system.

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[1]
Salazar-Viedma, M.; Vergaño-Salazar, J.G.; Pastenes, L.; D’Afonseca, V. Simulation model for hashimoto autoimmune thyroiditis disease. Endocrinology, 2021, 162(12), bqab190.
[http://dx.doi.org/10.1210/endocr/bqab190]
[2]
Lerner, A.; Jeremias, P.; Matthias, T. The world incidence and prevalence of autoimmune diseases is increasing. Int. J. Celiac Dis., 2015, 3(4), 151-155.
[http://dx.doi.org/10.12691/ijcd-3-4-8]
[3]
dos Santos, J.M.; Alencar, E.V.; de Oliveira Martins, E.C.; Ossoski, C.A.; de Fátima Bonetti, A. Vitamin D in patients with Hashimoto’s disease: A systematic review and meta-analysis. Rev. Cienc. Farm. Basica Apl., 2022, 43, 1-3.
[4]
McLeod, D.S.; Cooper, D.S. The incidence and prevalence of thyroid autoimmunity. Endocrine, 2012, 42(2), 252-265.
[http://dx.doi.org/10.1007/s12020-012-9703-2] [PMID: 22644837]
[5]
Franco, J.S.; Amaya-Amaya, J.; Anaya, J.M. Thyroid disease and autoimmune diseases. In: Autoimmunity: From Bench to Bedside; Anaya, J.M.; Shoenfeld, Y.; Rojas-Villarraga, A., Eds.; El Rosario University Press: Bogota, Colombia, 2013.
[6]
Dong, Y.H.; Fu, D.G. Autoimmune thyroid disease: Mechanism, genetics and current knowledge. Eur. Rev. Med. Pharmacol. Sci., 2014, 18(23), 3611-3618.
[PMID: 25535130]
[7]
Sattler, S. The role of the immune system beyond the fight against infection. Adv. Exp. Med. Biol., 2017, 1003, 3-14.
[http://dx.doi.org/10.1007/978-3-319-57613-8_1] [PMID: 28667551]
[8]
Gombart, A.F.; Pierre, A.; Maggini, S. A review of micronutrients and the immune system-working in harmony to reduce the risk of infection. Nutrients, 2020, 12(1), 236.
[http://dx.doi.org/10.3390/nu12010236] [PMID: 31963293]
[9]
Lavriša, Ž.; Hristov, H.; Hribar, M.; Žmitek, K.; Kušar, A. Koroušić Seljak, B.; Gregorič M.; Blaznik, U.; Gregorič N.; Zaletel, K.; Oblak, A.; Osredkar, J.; Pravst, I. Dietary intake and status of vitamin B12 in Slovenian population. Nutrients, 2022, 14(2), 334.
[http://dx.doi.org/10.3390/nu14020334] [PMID: 35057515]
[10]
Al-Musharaf, S.; McTernan, P.G.; Hussain, S.D.; Aleisa, K.A.; Alnaami, A.M.; Wani, K.; Saravanan, P.; Al-Daghri, N. Prevalence and indicators of vitamin B12 insufficiency among young women of childbearing age. Int. J. Environ. Res. Public Health, 2020, 18(1), 1.
[http://dx.doi.org/10.3390/ijerph18010001] [PMID: 33374905]
[11]
Sobczyńska-Malefora, A.; Delvin, E.; McCaddon, A.; Ahmadi, K.R.; Harrington, D.J. Vitamin B12 status in health and disease: A critical review. Diagnosis of deficiency and insufficiency - clinical and laboratory pitfalls. Crit. Rev. Clin. Lab. Sci., 2021, 58(6), 399-429.
[http://dx.doi.org/10.1080/10408363.2021.1885339] [PMID: 33881359]
[12]
Bandyopadhyay, D.; Choudhury, J.R.; Mukherjee, K. Vitamin B12 deficiency in Eastern India: A hospital based cross-sectional study. J. Clin. Diagn. Res., 2021, 15(4)
[http://dx.doi.org/10.7860/JCDR/2021/46642.14685]
[13]
Watanabe, F. Vitamin B12 sources and bioavailability. Exp. Biol. Med. (Maywood), 2007, 232(10), 1266-1274.
[http://dx.doi.org/10.3181/0703-MR-67] [PMID: 17959839]
[14]
Todorova, T.T.; Ermenlieva, N.; Tsankova, G. Vitamin B12: Could It Be a Promising Immunotherapy? In: Immunotherapy: Myths, Reality, Ideas, Future; Metodiev, K., Ed.; IntechOpen: London, 2017; p. 85.
[15]
Smith, A.D.; Warren, M.J.; Refsum, H. Vitamin B12. Adv. Food Nutr. Res., 2018, 83, 215-279.
[http://dx.doi.org/10.1016/bs.afnr.2017.11.005] [PMID: 29477223]
[16]
Vincenti, A.; Bertuzzo, L.; Limitone, A.; D’Antona, G.; Cena, H. Perspective: Practical approach to preventing subclinical B12 deficiency in elderly population. Nutrients, 2021, 13(6), 1913.
[http://dx.doi.org/10.3390/nu13061913] [PMID: 34199569]
[17]
Jaya Kumari, S.; Bantwal, G.; Devanath, A.; Aiyyar, V.; Patil, M. Evaluation of serum vitamin B12 levels and its correlation with anti-thyroperoxidase antibody in patients with autoimmune thyroid disorders. Indian J. Clin. Biochem., 2015, 30(2), 217-220.
[http://dx.doi.org/10.1007/s12291-014-0418-4] [PMID: 25883432]
[18]
Oh, R.; Brown, D.L. Vitamin B12 deficiency. Am. Fam. Physician, 2003, 67(5), 979-986.
[PMID: 12643357]
[19]
Nawaz, A.; Khattak, N.N.; Khan, M.S.; Nangyal, H.; Sabri, S.; Shakir, M. Deficiency of vitamin B12 and its relation with neurological disorders: A critical review. J. Basic Appl. Zool., 2020, 81(1), 1-9.
[20]
Sahoo, M.K.; Avasthi, A.; Singh, P. Negative symptoms presenting as neuropsychiatric manifestation of vitamin B12 deficiency. Indian J. Psychiatry, 2011, 53(4), 370-371.
[http://dx.doi.org/10.4103/0019-5545.91914] [PMID: 22303049]
[21]
Aktaş H.Ş. Vitamin B12 and vitamin D levels in patients with autoimmune hypothyroidism and their correlation with anti-thyroid peroxidase antibodies. Med. Princ. Pract., 2020, 29(4), 364-370.
[http://dx.doi.org/10.1159/000505094] [PMID: 31779003]
[22]
Bivona, G.; Gambino, C.M.; Lo Sasso, B.; Scazzone, C.; Giglio, R.V.; Agnello, L.; Ciaccio, M. Serum vitamin D as a biomarker in autoimmune, psychiatric and neurodegenerative diseases. Diagnostics (Basel), 2022, 12(1), 130.
[http://dx.doi.org/10.3390/diagnostics12010130] [PMID: 35054296]
[23]
Jiang, H.; Chen, X.; Qian, X.; Shao, S. Effects of vitamin D treatment on thyroid function and autoimmunity markers in patients with Hashimoto’s thyroiditis-A meta-analysis of randomized controlled trials. J. Clin. Pharm. Ther., 2022, jcpt.13605
[http://dx.doi.org/10.1111/jcpt.13605] [PMID: 34981556]
[24]
Stewart, R.; Hirani, V. Relationship between vitamin D levels and depressive symptoms in older residents from a national survey population. Psychosom. Med., 2010, 72(7), 608-612.
[http://dx.doi.org/10.1097/PSY.0b013e3181e9bf15] [PMID: 20595420]
[25]
El-Shafie, K.T. Clinical presentation of hypothyroidism. J. Family Community Med., 2003, 10(1), 55-58.
[PMID: 23011981]
[26]
Hitzhusen, J.C.; Taplin, M.E.; Stephenson, W.P.; Ansell, J.E. Vitamin B12 levels and age. Am. J. Clin. Pathol., 1986, 85(1), 32-36.
[http://dx.doi.org/10.1093/ajcp/85.1.32] [PMID: 3940418]
[27]
Agbaht, K.; Mercan, Y.; Kutlu, S.; Alpdemir, M.F.; Sezgin, T. Obesity with and without metabolic syndrome: Do vitamin D and thyroid autoimmunity have a role? Diabetes Res. Clin. Pract., 2014, 106(1), 27-34.
[http://dx.doi.org/10.1016/j.diabres.2014.08.001] [PMID: 25172520]
[28]
Collins, A.B.; Pawlak, R. Prevalence of vitamin B-12 deficiency among patients with thyroid dysfunction. Asia Pac. J. Clin. Nutr., 2016, 25(2), 221-226.
[PMID: 27222404]
[29]
Rose, N.R. Prediction and prevention of autoimmune disease in the 21st century: A review and preview. Am. J. Epidemiol., 2016, 183(5), 403-406.
[http://dx.doi.org/10.1093/aje/kwv292] [PMID: 26888748]
[30]
Niepomniszcze, H.; Amad, R.H. Skin disorders and thyroid diseases. J. Endocrinol. Invest., 2001, 24(8), 628-638.
[http://dx.doi.org/10.1007/BF03343905] [PMID: 11686547]
[31]
Kasumagić-Halilović E. Thyroid autoimmunity in patients with alopecia areata. Acta Dermatovenerol. Croat., 2008, 16(3), 123-125.
[PMID: 18812059]
[32]
Lok, U.; Hatipoglu, S.; Gulacti, U.; Arpaci, A.; Aktas, N.; Borta, T. The role of thyroid and parathyroid metabolism disorders in the etiology of sudden onset dizziness. Med. Sci. Monit., 2014, 20, 2689-2694.
[http://dx.doi.org/10.12659/MSM.891305] [PMID: 25512242]
[33]
Mazokopakis, E.E.; Kotsiris, D.A. Hashimoto’s autoimmune thyroiditis and vitamin D deficiency. Current aspects. Hell. J. Nucl. Med., 2014, 17(1), 37-40.
[http://dx.doi.org/10.1967/s002449910120] [PMID: 24563883]
[34]
Shin, D.Y.; Kim, K.J.; Kim, D.; Hwang, S.; Lee, E.J. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med. J., 2014, 55(2), 476-481.
[http://dx.doi.org/10.3349/ymj.2014.55.2.476] [PMID: 24532520]
[35]
Gaitonde, D.Y.; Rowley, K.D.; Sweeney, L.B. Hypothyroidism: An update. S. Afr. Fam. Pract., 2012, 86(3), 244-251.
[PMID: 22962987]
[36]
Ness-Abramof, R.; Nabriski, D.A.; Braverman, L.E.; Shilo, L.; Weiss, E.; Reshef, T.; Shapiro, M.S.; Shenkman, L. Prevalence and evaluation of B12 deficiency in patients with autoimmune thyroid disease. Am. J. Med. Sci., 2006, 332(3), 119-122.
[http://dx.doi.org/10.1097/00000441-200609000-00004] [PMID: 16969140]
[37]
Wang, Y.P.; Lin, H.P.; Chen, H.M.; Kuo, Y.S.; Lang, M.J.; Sun, A. Hemoglobin, iron, and vitamin B12 deficiencies and high blood homocysteine levels in patients with anti-thyroid autoantibodies. J. Formos. Med. Assoc., 2014, 113(3), 155-160.
[http://dx.doi.org/10.1016/j.jfma.2012.04.003] [PMID: 24630032]
[38]
Lei, Y.; Yang, J.; Li, H.; Zhong, H.; Wan, Q. Changes in glucose-lipid metabolism, insulin resistance, and inflammatory factors in patients with autoimmune thyroid disease. J. Clin. Lab. Anal., 2019, 33(7), e22929.
[http://dx.doi.org/10.1002/jcla.22929] [PMID: 31350776]

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