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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

New Bicyclic Lactone by Biotransformation of β-caryophyllene using Aspergillus niger

Author(s): Qutaiba Al-Dulaimi, Mohammad Yasin Mohammad*, Manal Al-Najdawi, Yusuf M. Al-Hiari, Haroon M. Haniffa and M. Iqbal Choudhary

Volume 19, Issue 12, 2022

Published on: 15 August, 2022

Page: [1132 - 1135] Pages: 4

DOI: 10.2174/1570178619666220615094240

Price: $65

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Abstract

Microbial transformation of β-caryophyllene (1) by suspended cell cultures of the plant pathogen fungus Aspergillus niger, resulted in the production of one major metabolite. This metabolite was identified as (3aR,11aS, E)-9-methyl-4-methylene-3a,4,7,10,11,11a-hexahydro-2H-furo[3,2- c]oxecine-2,6(3H)-dione (2), by different spectroscopic methods. Metabolite 2 was found to be a new compound. The proposed pathway for the synthesis of compound 2 was also explained.

Keywords: β-Caryophyllene, Aspergillus niger, fungal transformation, demethylation, oxidation, metabolite.

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