Login Register Cart 0
Generic placeholder image

Recent Advances in Inflammation & Allergy Drug Discovery

Editor-in-Chief

ISSN (Print): 2772-2708
ISSN (Online): 2772-2716

Back
Journal Home About Journal Editorial Board Current Issue Volumes/Issues
Subscribe
Case Report

Linezolid Intoxication with Extreme Lactate Blood Levels Successfully Treated with Dialytic Treatment in ICU: A Case Report

Author(s): Lorenzo Schiavoni, Alessia Mattei, Giuseppe Pascarella, Alessandro Strumia*, Antonio Nenna, Massimo Chello and Felice E. Agrò

Volume 16, Issue 1, 2022

Published on: 28 June, 2022

Page: [50 - 53] Pages: 4

DOI: 10.2174/2772270816666220606111049

Price: $65

Abstract

Introduction: Lactic acidosis is a rare but life-threatening complication associated with prolonged linezolid therapy. No specific treatment is suggested, except for antibiotic therapy interruption.

Case Report: A 70-years-old woman faced severe linezolid intoxication after antibiotics therapy initiation for infection of a surgical sternal wound. The patient suffered from a severe increment of blood lactate and thrombocytopenia. She was admitted to ICU twice, and due to dialytic treatment, linezolid and lactate serum levels came back to normality.

Conclusion: More studies should be conducted to evaluate the human tissue storage sites of linezolid and the influence of various factors on its clearance and plasma concentrations in critically ill patients.

Keywords: linezolid toxicity, dialysis, lactic acidosis, lactate, intensive care unit (ICU), antibiotics therapy.

« Previous Next »
Graphical Abstract

[1]
Hashemian SMR, Farhadi T, Ganjparvar M. Linezolid: A review of its properties, function, and use in critical care. Drug Des Devel Ther 2018; 12: 1759-67.
[http://dx.doi.org/10.2147/DDDT.S164515] [PMID: 29950810]
[2]
Depeint F, Bruce WR, Shangari N, Mehta R, O’Brien PJ. Mitochondrial function and toxicity: Role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact 2006; 163(1-2): 94-112.
[http://dx.doi.org/10.1016/j.cbi.2006.04.014] [PMID: 16765926]
[3]
Jackson MA, Holland MR, Nicholas J, Lodwick R, Forster D, Macdonald IA. Hemodialysis-induced hypoglycemia in diabetic patients. Clin Nephrol 2000; 54(1): 30-4.
[PMID: 10939754]
[4]
Garrabou G, Soriano À, Pinós T, et al. Influence of mitochondrial genetics on the mitochondrial toxicity of linezolid in blood cells and skin nerve fibers. Antimicrob Agents Chemother 2017; 61(9): 61.
[http://dx.doi.org/10.1128/AAC.00542-17] [PMID: 28674062]
[5]
Villa G, di Maggio P, de Gaudio AR, et al. Effects of continuous renal replacement therapy on linezolid pharmacokinetic/pharmacodynamics: A systematic review. Crit Care 2016; 20(1): 374.
[http://dx.doi.org/10.1186/s13054-016-1551-7] [PMID: 27863531]
[6]
Barrasa H, Soraluce A, Isla A, et al. Pharmacokinetics of linezolid in critically ill patients on continuous renal replacement therapy: Influence of residual renal function on PK/PD target attainment. J Crit Care 2019; 50: 69-76.
[http://dx.doi.org/10.1016/j.jcrc.2018.11.016] [PMID: 30496913]
[7]
Zheng J, Sun Z, Sun L, et al. Pharmacokinetics and pharmacodynamics of linezolid in patients with sepsis receiving continuous venovenous hemofiltration and extended daily hemofiltration. J Infect Dis 2020; 221 (Suppl. 2): S279-87.
[http://dx.doi.org/10.1093/infdis/jiz566] [PMID: 32176792]
[8]
Meyer B, Kornek GV, Nikfardjam M, et al. Multiple-dose pharmacokinetics of linezolid during continuous venovenous haemofiltration. J Antimicrob Chemother 2005; 56(1): 172-9.
[http://dx.doi.org/10.1093/jac/dki133] [PMID: 15905303]
[9]
Supinski GS, Schroder EA, Callahan LA. Mitochondria and critical illness. Chest 2020; 157(2): 310-22.
[http://dx.doi.org/10.1016/j.chest.2019.08.2182] [PMID: 31494084]
[10]
Moraza L, Leache L, Aquerreta I, Ortega A. Linezolid-induced haematological toxicity. Farm Hosp 2015; 39(6): 320-6.
[PMID: 26618376]

Rights & Permissions Print Cite
Article Metrics
14
© 2024 Bentham Science Publishers | Privacy Policy