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Current Genomics

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ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

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Review Article

Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review

Author(s): Farhad Babaie, Melodi Omraninava, Armita Mahdavi Gorabi, Arezou Khosrojerdi, Saeed Aslani, Arsalan Yazdchi, Shahram Torkamandi*, Haleh Mikaeili*, Thozhukat Sathyapalan and Amirhossein Sahebkar*

Volume 23, Issue 3, 2022

Published on: 09 June, 2022

Page: [163 - 174] Pages: 12

DOI: 10.2174/1389202923666220527111037

Price: $65

Abstract

Psoriasis is an organ-specific autoimmune disease characterized by the aberrant proliferation and differentiation of keratinocytes, leading to skin lesions. Abnormal immune responses mediated by T cells and dendritic cells and increased production of inflammatory cytokines have been suggested as underlying mechanisms in the pathogenesis of psoriasis. Emerging evidence suggests that there is a heritable basis for psoriatic disorders. Moreover, numerous gene variations have been associated with the disease risk, particularly those in innate and adaptive immune responses and antigen presentation pathways. Herein, this article discusses the genetic implications of psoriatic diseases' etiopathogenesis to develop novel investigative and management options.

Keywords: Genetics, immune response, autoimmunity, psoriasis, etiopathogenesis, keratinocytes.

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Graphical Abstract

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