The Correlation between 25-Hydroxyvitamin D Levels and Testosterone Levels in Type 2 Diabetic Male Patients

Title:The Correlation between 25-Hydroxyvitamin D Levels and Testosterone Levels in Type 2 Diabetic Male Patients

Volume: 23

Author(s): Mohamed M. Aboelnaga*, Abdullah Nahed, Sherihan I. Gouda and Amro Elbaz

Affiliation:

• Department of Endocrinology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Keywords: Vitamin D, Testosterone, Type 2 DM, Male hypogonadism, 25OH D, Testosterone deficiency.

Abstract:

Background: Hypovitaminosis D and low testosterone levels are common in men with T2DM, and vitamin D has been proposed to regulate pituitary-testicular function.

Objective: We investigated the association between testosterone levels and the circulating vitamin D among type 2 diabetic males.

Methods: We recruited 95 males with type 2 diabetes in this cross-sectional study and investigated the circulating form of vitamin D, which is 25-hydroxyvitamin D (25(OH) D). 25(OH) D level <30 ng/mL was used to define vitamin D insufficiency, and 25(OH) D level <20 ng/ml was defined as a deficiency. Testosterone deficiency was described as a total testosterone level less than 300 ng/dl.

Result: Testosterone deficiency prevalence in type 2 diabetic males was found to be 46.3%. Testosterone deficient people with diabetes had significantly lower 25(OH) D levels than patients with normal testosterone. We observed a higher prevalence of vitamin D deficiency in testosterone deficient people with diabetes than testosterone sufficient patients. Furthermore, significantly lower total testosterone levels but not LH levels were observed in diabetic males with vitamin D deficiency compared to nondeficient patients. We observed that 25(OH) D significantly predicted total testosterone levels in diabetic males evaluated by linear regression analysis. However, this association was no longer statistically significant after excluding macro-albuminuric patients. Moreover, vitamin D deficiency was found to be a significant risk factor for testosterone deficiency in logistic regression analysis.

Conclusion: Testosterone deficient males with diabetes had significantly lower 25(OH)D levels and a higher prevalence of vitamin D deficiency than normal testosterone diabetic males. Likewise, vitamin D deficient patients had lower testosterone levels. Overall, 25(OH) D significantly predicted total testosterone levels. Vitamin D deficiency was thus a significant risk factor for testosterone deficiency in diabetic males.

Cite this article as:

Aboelnaga M. Mohamed*, Nahed Abdullah, Gouda I. Sherihan and Elbaz Amro, The Correlation between 25-Hydroxyvitamin D Levels and Testosterone Levels in Type 2 Diabetic Male Patients, Endocrine, Metabolic & Immune Disorders - Drug Targets 2023; 23 () . https://dx.doi.org/10.2174/1871530322666220524104929