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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

Molecular Iodine-Catalyzed N-Benzylic Sulfonamides C-N Bond Cleavage for the Decarboxylative Substitution of β-Keto Acids

Author(s): Lina Jia*, Jinyu Zhao and Xiangping Hu*

Volume 19, Issue 11, 2022

Published on: 18 July, 2022

Page: [924 - 930] Pages: 7

DOI: 10.2174/1570178619666220516124320

Price: $65

Abstract

A molecular iodine-catalyzed system for the decarboxylative substitution reactions of β-keto acids with N-benzylic sulfonamides via sp3 C-N bond cleavage has been disclosed. This procedure provides a series of α-functionalized ketones in good to excellent yields. Furthermore, the practicability of this method could be manifested efficiently in a gram-scale synthesis.

Keywords: Decarboxylative Substitution, iodine, N-benzylic sulfonamide, C-N bond cleavage, β-keto acids, sp3.

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