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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Isolation, Bioactivities, and Synthesis of Lamellarin Alkaloids: A Review

Author(s): Dau Xuan Duc* and Nguyen Van Quoc

Volume 26, Issue 10, 2022

Published on: 04 August, 2022

Page: [961 - 990] Pages: 30

DOI: 10.2174/1385272826666220516114926

Price: $65

Abstract

Lamellarin alkaloid is a large class of marine alkaloids with diverse bioactivities. These heterocycles have been isolated from diverse marine organisms, mainly ascidians and sponges. They possess a fused 14-phenyl-6H-[1]benzopyrano[40,30:4,5] pyrrolo[2,1- a]isoquinoline or non-fused 3,4-diarylpyrrole-2-carboxylate ring systems. Until now, more than 50 lamellarins have been isolated from marine organisms. Various lamellarins exhibit valuable bioactivities, such as cytotoxicity, topoisomerase I inhibition, protein kinases inhibition, multidrug resistance reversal, and anti-HIV-1 activity. Due to their valuable biological activity, the synthesis of lamerallins has received great attention of chemists and a vast number of synthetic methods have been developed. This article gives overview of studies on lamellarins isolation, their bioactivities, and synthetic approaches for their total synthesis.

Keywords: Anticancer, marine organism, isoquinoline, fused pyrrole, lactonization, cross-coupling, pyruvic acid.

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