Recent Advances in Nanotechnology-Based Targeted Therapeutics for Breast Cancer Management

Title:Recent Advances in Nanotechnology-Based Targeted Therapeutics for Breast Cancer Management

Volume: 23 Issue: 8

Author(s): Abdulsalam Alhalmi, Sarwar Beg*, Waleed H. Almalki, Saad Alghamdi and Kanchan Kohli*

Affiliation:

• Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India
• School of Pharmacy and Biomedical Sciences, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK

• Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India

Keywords: Breast cancer, active targeted, nanocarriers, receptors, ligands, chemotherapy.

Abstract: Despite the great efforts that have been achieved in breast cancer treatment, it remains a significant cause of death in women and is a serious health problem. Treatment with chemotherapy drugs faces various challenges, such as toxicity and chemoresistance to chemotherapeutic drugs, which hinder their therapeutic success and clinical experiments. This review focuses on targeting nanocarrier approaches to target chemotherapy drugs to receptor targets that are overexpressed on the surface of breast cancer cells. In particular, the most commonly targeted nanocarriers for the chemotherapeutic agents examined by the different researcher groups, such as liposomes, dendrimers, polymeric micelles, lipid particulates, polymeric nanoparticles, and carbon nanotubes, have been reviewed. Moreover, we summarized the molecular receptors or targets that are the most commonly overexpressed in breast cancer cells and the natural and synthetic ligands studied for use as targeting moieties to functionalize chemotherapeutically loaded nanocarriers for potential specific breast cancer targeting.

Cite this article as:

Alhalmi Abdulsalam, Beg Sarwar*, Almalki H. Waleed, Alghamdi Saad and Kohli Kanchan*, Recent Advances in Nanotechnology-Based Targeted Therapeutics for Breast Cancer Management, Current Drug Metabolism 2022; 23 (8) . https://dx.doi.org/10.2174/1389200223666220514151110