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Current Cancer Therapy Reviews

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ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

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Case Report

Neoadjuvant Chemotherapy, Carboplatin, and Paclitaxel in Pregnancy of a 22-Year Old with Stage IIA2 Cervical Cancer

Author(s): Tatit Nurseta*, Anggia Prameswari Wardhana* and Mukhammad Nooryanto

Volume 18, Issue 4, 2022

Published on: 06 September, 2022

Page: [316 - 320] Pages: 5

DOI: 10.2174/1573394718666220513115452

Price: $65

Abstract

Background: Cervical cancer is the second most common cancer found in pregnant women at a young age. Neoadjuvant with carboplatin and paclitaxel is often given to patients with cervical cancer, but the experience of administration during pregnancy is very limited.

Case: A 22-year-old woman was diagnosed with stage IIA2 cervical cancer at 26 weeks gestation. The patient received three medications, including neoadjuvant chemotherapy, carboplatin, and paclitaxel, in three cycles with three weeks intervals at 27 weeks gestation. The patient underwent pregnancy termination with emergency cesarean delivery at 36 weeks of gestation and continued with a hysterectomy radical for 60 days, after which the patient received a chemoradiation adjuvant. Mother and baby were found healthy at one year after the diagnosis.

Conclusion: NACT inhibited progression of the disease and allowed fetal maturity in locally advanced cervical cancer patient at a young age, followed by radical hysterectomy 60 weeks after cesarean section. The combination of carboplatin and paclitaxel seemed feasible and relatively safe for both the mother and the baby.

Keywords: cervical cancer, neoadjuvant chemotherapy, pregnancy, radical hysterectomy, young age

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