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Anti-Cancer Agents in Medicinal Chemistry

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ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

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Review Article

Anticancer Potential of Thymoquinone: A Novel Bioactive Natural Compound from Nigella sativa L.

Author(s): Prince Ahad Mir, Roohi Mohi-ud-din, Nazia Banday, Mudasir Maqbool, Syed Naeim Raza, Saeema Farooq, Suhaib Afzal and Reyaz Hassan Mir*

Volume 22, Issue 20, 2022

Published on: 04 August, 2022

Page: [3401 - 3415] Pages: 15

DOI: 10.2174/1871520622666220511233314

Price: $65

Abstract

Cancer involves the uncontrolled division of cells resulting in abnormal cell growth due to various gene mutations and is considered the second major cause of death. Due to drug resistance to current anticancer drugs, cancer incidence is rising, and seeking effective treatment is a major concern. Natural products are prospective to yield unique molecules, as nature is a leading source of various drug molecules due to plenty of pharmacologically active molecules. Thymoquinone, a bioactive constituent obtained from Nigella sativa L., has drawn considerable attention among researchers in recent years due to its anticancer potential involving various molecular targets, including initiation of apoptosis initiation, arrest of cell cycle and generation of ROS, besides targeting multiple kinases such as tyrosine kinase, MAPK, and Janus kinase. The current review summarizes the thymoquinone chemistry, sources and anticancer potential involving various molecular targets.

Keywords: Nigella sativa, thymoquinone, plant products, anticancer therapeutics, apoptosis, Janus kinase.

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