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Current Drug Research Reviews

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ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

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Review Article

Biochanin-A: A Bioactive Natural Product with Versatile Therapeutic Perspectives

Author(s): Vadivelan Ramachandran*, Inba Kumar V, Kiran Kumar hr, Ruchi Tiwari and Gaurav Tiwari

Volume 14, Issue 3, 2022

Published on: 23 August, 2022

Page: [225 - 238] Pages: 14

DOI: 10.2174/2589977514666220509201804

Price: $65

Abstract

Background: Biochanin-A (5,7 dihydroxy 4 methoxy isoflavone) is a phytochemical phytoestrogen that is highly effective against various diseases. Biochanin-A is a nutritional and dietary isoflavonoid naturally present in red clover, chickpea, soybeans and other herbs. Biochanin- A possesses numerous biological activities.

Objective: The study focused on collective data of therapeutic activities of Biochanin-A.

Methods: According to the literature, biochanin-A revealed a range of activities starting from chemoprevention, by hindering cell growth, activation of tumor cell death, hampering metastasis, angiogenic action, cell cycle regulation, neuroprotection, by controlling microglial activation, balancing antioxidants, elevating the neurochemicals, suppressing BACE-1, NADPH oxidase hindrance to inflammation, by mitigating the MAPK and NF- κB, discharge of inflammatory markers, upregulating the PPAR-γ, improving the function of heme oxygenase-1, erythroid 2 nuclear factors, detoxifying the oxygen radicals and stimulating the superoxide dismutase action, and controlling its production of transcription factors. Against pathogens, biochanin-A acts by dephosphorylating tyrosine kinase proteins, obstructing gram-negative bacteria, suppressing the development of cytokines from viruses, and improving the action of a neuraminidase cleavage of caspase-3, and acts as an efflux pump inhibitor. In metabolic disorders, biochanin-A acts by encouraging transcriptional initiation and inhibition, activating estrogen receptors, and increasing the activity of differentiation, autophagy, inflammation, and blood glucose metabolism.

Conclusion: Therefore, biochanin-A could be used as a therapeutic drug for various pathological conditions and treatments in human beings.

Keywords: biochanin-A, chemoprevention, neuroprotection, anti-inflammatory, anti-microbial, metabolic disorders

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