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Current Drug Research Reviews

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ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

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Review Article

The Incredible Potential of Exosomes as Biomarkers in the Diagnosis of Colorectal Cancer

Author(s): Sankha Bhattacharya*

Volume 14, Issue 3, 2022

Published on: 16 August, 2022

Page: [188 - 202] Pages: 15

DOI: 10.2174/2665998002666220501164429

Price: $65

Abstract

Colorectal cancer (CRC) is common cancer that is one of the leading causes of cancerrelated deaths around the world. The creation of new biomarkers for this disease is an important public health strategy for lowering the disease's mortality rate. According to new research, exosomes may be important sources of biomarkers in CRC. Exosomes are nanometer-sized membrane vesicles (30-200 nm) secreted by normal and cancer cells that transport RNA and proteins between cells and are thought to help with intercellular communication. Exosomes have been linked to CRC initiation and progression, and some differentially expressed RNAs and proteins in exosomes have been identified as potential cancer detection candidates. As a result, studying the relationship between exosomes and CRC may aid in the development of new biomarkers for the disease. This article discusses the importance of exosomes as biomarkers in the diagnosis of CRC, as well as their use in the treatment of CRC metastasis, chemoresistance, and recrudescence. The benefits and drawbacks of using exosomes as tumour markers are also discussed.

Keywords: Colorectal cancer (CRC), lncRNAs; Exosomes, Multiplexed vesicular bodies (MVBs), Intraluminal vesicles (ILVs), Exosomal IRF-2

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