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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

癌细胞转化中的自噬：一种潜在的新型治疗策略

卷 22, 期 9, 2022

发表于: 05 July, 2022

页: [749 - 756] 页: 8

弟呕挨: 10.2174/1568009622666220428102741

价格: $65

摘要

基础自噬在维持细胞内稳态和防止细胞逃避细胞周期调节机制和癌变方面起着至关重要的作用。 Mitophagy 和 nucleophagy 对细胞健康至关重要。自噬在癌细胞转化中起关键作用，其中上调的癌前自噬诱导细胞凋亡。已显示受损的自噬可上调癌细胞转化。然而，肿瘤细胞上调自噬以逃避消除并在不利条件和对化疗的抵抗中存活下来。癌细胞通过调节自噬调控机制促进自噬，增加自噬相关基因的表达。然而，自噬调节机制涉及 microRNA、转录因子和内化信号通路，如 AMPK、mTOR、III PI3K 和 ULK-1。被破坏的调节机制是多种多样的，如癌细胞多态性。针对更高水平的自噬调节更有效，例如负责上调癌细胞自噬的基因表达、转录因子或表观遗传修饰。目前，CRISPR-CAS9技术已经可用，可用于证明自噬在癌细胞中的潜在作用。

关键词: 自噬、转移、转化、肿瘤发生、发病机制、噬核、线粒体自噬、血管生成。

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