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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Perspective

β-lapachone：一种在胰腺癌中具有独特NQO1特异性凋亡的有前景的抗癌药物

卷 22, 期 7, 2022

发表于: 31 May, 2022

页: [537 - 540] 页: 4

弟呕挨: 10.2174/1568009622666220427121127

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摘要

癌症是全世界的主要健康问题之一，需要更有效的药物用于临床。最近正在研究的一种可能的化疗药物是β-lapachone。β-lapachone（1,2-萘醌）对显示烟酰胺二磷酸醌氧化还原酶-1（NQO1）水平升高的肿瘤具有很好的活性。发现NQO1在胰腺肿瘤细胞中上调，因此β-lapachone可在胰腺肿瘤等各种癌症中产生细胞毒性。β-lapachone在琼脂中具有独立生长和克隆形成细胞存活。使用NAD（P）H醌氧化还原酶-1抑制剂双香酚可以阻止β-lapachone的细胞杀伤作用。在先前建立的小鼠胰腺癌异种移植物中，β-lapachone在口服时抑制肿瘤生长，而不是与环糊精联合使用，以提高其生物利用度。

关键词: NAD（P）H醌氧化还原酶-1，β-lapachone，活性氧物种，醌，环糊精，人胰腺癌。

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图形摘要

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