Login Register Cart 0
Generic placeholder image

Current Nanomedicine

Editor-in-Chief

ISSN (Print): 2468-1873
ISSN (Online): 2468-1881

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Applications of Herbal Drug Delivery Through a Targeted Approach Using Vesicular Carriers

Author(s): Dipthi Shree*, Chinam N. Patra, Sasmita K. Acharjya and Biswa M. Sahoo

Volume 12, Issue 1, 2022

Published on: 16 May, 2022

Page: [2 - 16] Pages: 15

DOI: 10.2174/1871520622666220425093718

Price: $65

Abstract

Background and Objective: Herbal medicines exhibit pronounced therapeutic activity with minimal toxic effects. The use of the herbal drug through the oral route is considered to be an impediment owing to its poor bioavailability. Therefore, an alternative approach to the Transdermal route was adopted. It has been a challenge for pharmaceutical scientists to deliver the herbal compound effectively through the skin due to the presence of the impregnable layer i.e. the Stratum corneum. Various strategies were employed to overcome the obstruction property of the skin. Firstly, vesicular liposomes were developed and they were unable to access the intact skin layer namely the stratum corneum. Later the use of novel lipid-based vesicular carriers such as ethosomes, invasomes, glycerosomes, transferosomes, and transethosomes for herbal drug delivery showed an increased efficiency to penetrate through the stratum corneum. Furthermore, the use of novel niosomes and proniosomes which are categorized as surfactant-based vesicular carriers improves the skin permeation of the herbal medication.

Methods: In this current review, painstaking efforts were made to compile and update the various applications of the emerging vesicular carriers such as ethosomes, transethosomes, transferosomes, glycerosomes, invasomes, niosomes, and proniosomes which are employed in herbal drug formulations. This article portrays a detailed survey about varied applications as viz., anti-cancer, anti-acne, anti-oxidant, anti-inflammatory, anti-microbial, anti-aging, anti-diabetic, etc. in the form of tables.

Conclusion: The application of herbal medicines by employing a suitable novel carrier can exhibit a pronounced therapeutic activity. Therefore, extensive research in the field of herbal drug technology is carried out to impart the phytoconstituents to the targeted sites.

Keywords: Herbal medicine, novel carrier, transdermal route, stratum corneum, penetration enhancer, non-ionic surfactants.

« Previous Next »
Graphical Abstract

[1]
Chamundeeswar M, Jeslin J, Verma ML. Nanocarriers for drug delivery applications. Environ Chem Lett 2019; 17(2): 849-65.
[http://dx.doi.org/10.1007/s10311-018-00841-1]
[2]
Obeid MA, Al Qaraghuli MM, Alsaadi M, Alzahrani AR, Niwasabutra K, Ferro VA. Delivering natural products and biotherapeutics to improve drug efficacy. Ther Deliv 2017; 8(11): 947-56.
[http://dx.doi.org/10.4155/tde-2017-0060] [PMID: 29061102]
[3]
Kumar R, Kumar S, Jha SS, Jha AK. Vesicular system-carrier for drug delivery. Pharm Sin 2011; 2(4): 192-202.
[4]
Singh D, Pradhan M, Nag M, Singh MR. Vesicular system: Versatile carrier for transdermal delivery of bioactives. Artif Cells Nanomed Biotechnol 2015; 43(4): 282-90.
[http://dx.doi.org/10.3109/21691401.2014.883401] [PMID: 24564350]
[5]
Touitou E, Dayan N, Levi-Schaffer F, Piliponsky A. Novel lipid vesicular system for enhanced delivery. J Lipid Res 1998; 8: 113-4.
[6]
Goyal A, Kumar S, Nagpal M, Singh I, Arora S. Potential of novel drug delivery systems for herbal drugs. Indian J Pharm Educ Res 2011; 45: 225-35.
[7]
Atmakuri LR, Dathi S. Current trends in herbal medicines. J Pharm Res 2010; 3(1): 109-13.
[8]
Vyas SP, Khar RK. Targeted and Controlled Drug Delivery. 1st ed. CBS Publisher 2013; pp. 3-10.
[9]
Cheng Y-C, Li TS, Su HL, Lee PC, Wang HD. Transdermal delivery systems of natural products applied to skin therapy and care. Molecules 2020; 25(21): 5051.
[http://dx.doi.org/10.3390/molecules25215051] [PMID: 33143260]
[10]
Mukherjee PK, Wahile A. Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. J Ethnopharmacol 2006; 103(1): 25-35.
[http://dx.doi.org/10.1016/j.jep.2005.09.024] [PMID: 16271286]
[11]
Thakur L, Ghodasra U, Patel N, Dabhi M. Novel approaches for stability improvement in natural medicines. Pharmacogn Rev 2011; 5(9): 48-54.
[http://dx.doi.org/10.4103/0973-7847.79099] [PMID: 22096318]
[12]
Ioele G, Tavano L, Luca M, Muzzalupo R, Mancuso A, Ragno G. Light-sensitive drugs in topical formulations: Stability indicating methods and photostabilization strategies. Future Med Chem 2017; 9(15): 1795-808.
[http://dx.doi.org/10.4155/fmc-2017-0105] [PMID: 28925725]
[13]
Korać RR, Khambholja KM. Potential of herbs in skin protection from ultraviolet radiation. Pharmacogn Rev 2011; 5(10): 164-73.
[http://dx.doi.org/10.4103/0973-7847.91114] [PMID: 22279374]
[14]
Tonnesen HH. Photostability of Drugs and Drug Formulations. 2nd ed. Boca Raton, FL, USA: CRC Press 2004; pp. 11-26.
[http://dx.doi.org/10.1201/9780367801021]
[15]
Ioele G, De Luca M, Garofalo A, Ragno G. Photosensitive drugs: A review on their photoprotection by liposomes and cyclodextrins. Drug Deliv 2017; 24(sup1): 33-4.
[http://dx.doi.org/10.1080/10717544.2017.1386733] [PMID: 29069944]
[16]
Touitou E, Godin B. Vesicular carriers for enhanced delivery through the skin. In: Enhancement in Drug Delivery. CRC Press 2016; pp. 255-78.
[17]
Arora R, Aggarwal G, Dhingra GA, Nagpal M. Herbal active ingredients used in skin cosmetics. Asian J Pharm Clin Res 2019; 12(9): 7-15.
[http://dx.doi.org/10.22159/ajpcr.2019.v12i9.33620]
[18]
Ribeiro AS, Estanqueiro M, Oliveira MB, Lobo JMS. Main benefits and applicability of plant extracts in skin care products. Cosmetics 2015; 2(2): 48-65.
[http://dx.doi.org/10.3390/cosmetics2020048]
[19]
Aburjai T, Natsheh FM. Plants used in cosmetics. Phytother Res 2003; 17(9): 987-1000.
[http://dx.doi.org/10.1002/ptr.1363] [PMID: 14595575]
[20]
Niculae G, Lacatusu I, Badea N, Stan R, Vasile BS, Meghea A. Rice bran and raspberry seed oil-based nanocarriers with self-antioxidative properties as safe photoprotective formulations. Photochem Photobiol Sci 2014; 13(4): 703-16.
[http://dx.doi.org/10.1039/c3pp50290b] [PMID: 24590004]
[21]
Jun SH, Kim H, Lee H, Song JE, Park SG, Kang NG. Synthesis of retinol-loaded lipid nanocarrier via vacuum emulsification to improve topical skin delivery. Polymers (Basel) 2021; 13(5): 826.
[http://dx.doi.org/10.3390/polym13050826] [PMID: 33800335]
[22]
Sarangi MK, Padhi S. Novel herbal drug delivery system: An overview. Arch Med Health Sci 2018; 6(1): 171-9.
[http://dx.doi.org/10.4103/amhs.amhs_88_17]
[23]
Cevc G, Vierl U. Nanotechnology and the transdermal route: A state of the art review and critical appraisal. J Control Release 2010; 141(3): 277-99.
[http://dx.doi.org/10.1016/j.jconrel.2009.10.016] [PMID: 19850095]
[24]
Touitou E, Godin B. Vesicular Carriers for Enhanced Delivery through the Skin. 1st ed. CRC Press 2011; p. 24.
[25]
Ajazuddin SS, Saraf S. Applications of novel drug delivery system for herbal formulations. Fitoterapia 2010; 81(7): 680-9.
[http://dx.doi.org/10.1016/j.fitote.2010.05.001] [PMID: 20471457]
[26]
Gunasekaran T, Haile T, Nigusse T, Dhanaraju MD. Nanotechnology: An effective tool for enhancing bioavailability and bioactivity of phytomedicine. Asian Pac J Trop Biomed 2014; 4(1)(Suppl. 1): S1-7.
[http://dx.doi.org/10.12980/APJTB.4.2014C980] [PMID: 25183064]
[27]
Kumar L, Verma S, Singh K, Prasad DN, Jain AK. Ethanol based vesicular carriers in transdermal drug delivery: Nanoethosomes and transethosomes in focus. NanoWorld J 2016; 2(3): 41-51.
[28]
Abdulbaqi IM, Darwis Y, Khan NAK, Assi RA, Khan AA. Ethosomal nanocarriers: The impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials. Int J Nanomedicine 2016; 11: 2279-304.
[http://dx.doi.org/10.2147/IJN.S105016] [PMID: 27307730]
[29]
Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes - novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties. J Control Release 2000; 65(3): 403-18.
[http://dx.doi.org/10.1016/S0168-3659(99)00222-9] [PMID: 10699298]
[30]
Song CK, Balakrishnan P, Shim CK, Chung SJ, Chong S, Kim DD. A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: Characterization and in vitro/in vivo evaluation. Colloids Surf B Biointerfaces 2012; 92: 299-304.
[http://dx.doi.org/10.1016/j.colsurfb.2011.12.004] [PMID: 22205066]
[31]
Mishra KK, Kaur CD, Verma S, et al. Transethosomes and nanoethosomes: Recent approach on transdermal drug delivery system. Nanomedicine (Lond) 2019; 2: 33-54.
[32]
Joseph AE, Abrahm S, Beena P, Das C, Joseph S. A review on ethosomes: Novel drug delivery system. J Glob Trends Pharm Sci 2019; 10(3): 6340-6.
[33]
Sultana B, Rajak P, Bhuyan B, et al. Therapeutic potential of herbal ethosome in applied nanotechnology. Saudi J Med Pharm Sci 2018; 4(4): 443-54.
[34]
Zhang Y, Xia Q, Li Y, et al. CD44 assists the topical anti-psoriatic efficacy of curcumin-loaded hyaluronan-modified ethosomes: A new strategy for clustering drug in inflammatory skin. Theranostics 2019; 9(1): 48-64.
[http://dx.doi.org/10.7150/thno.29715] [PMID: 30662553]
[35]
Jeswani G, Saraf S. Topical delivery of curcuma longa extract loaded nanosized ethosomes to combat facial wrinkles. J Pharm Drug Deliv Res 2014; 3(1): 1-8.
[36]
Hallan SS, Sguizzato M, Mariani P, et al. Design and characterization of ethosomes for transdermal delivery of caffeic acid. Pharmaceutics 2020; 12(8): 740.
[http://dx.doi.org/10.3390/pharmaceutics12080740] [PMID: 32781717]
[37]
Soni K, Mujtaba A, Akhter MH, Zafar A, Kohli K. Optimisation of ethosomal nanogel for topical nano-CUR and sulphoraphane delivery in effective skin cancer therapy. J Microencapsul 2020; 37(2): 91-108.
[http://dx.doi.org/10.1080/02652048.2019.1701114] [PMID: 31810417]
[38]
Sundari BT, Rao PS, Sireesha K, Sai YK. Formulation and evaluation of ethosomal gels of Mangifera indica leaf extract. IAJPS 2017; 4(6): 1755-61.
[39]
Parameswaran S, Snehalata J. Formulation development and evaluation of Antiacne activity of ethosomal gel prepared using Plumbago zeylanica root extract. Int J Res Pharm Sci 2020; 11(4): 5511-6.
[http://dx.doi.org/10.26452/ijrps.v11i4.3185]
[40]
Zhaowu Z, Xiaoli W, Yangde Z, Nianfeng L. Preparation of matrine ethosome, its percutaneous permeation in vitro and anti-inflammatory activity in vivo in rats. J Liposome Res 2009; 19(2): 155-62.
[http://dx.doi.org/10.1080/08982100902722381] [PMID: 19241204]
[41]
Surini S, Arnedy AR, Iswandana R. Development of ethosome containing bitter melon (Momordica charantia linn.) fruit fraction and in vitro skin penetration. Pharmacogn J 2019; 11(6): 1242-51.
[http://dx.doi.org/10.5530/pj.2019.11.193]
[42]
Shen LN, Zhang YT, Wang Q, Xu L, Feng NP. Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes. Int J Pharm 2014; 460(1-2): 280-8.
[http://dx.doi.org/10.1016/j.ijpharm.2013.11.017] [PMID: 24269286]
[43]
Ma H, Guo D, Fan Y, Wang J, Cheng J, Zhang X. Paeonol-loaded ethosomes as transdermal delivery carriers: Design, preparation and evaluation. Molecules 2018; 23(7): 1756.
[http://dx.doi.org/10.3390/molecules23071756] [PMID: 30018278]
[44]
Somwanshi SB, Hiremath SN. Development and evaluation of novel ethosomal vesicular drug delivery system of Sesamum indicum l. seed extract. Asian J Pharm 2018; 12(4): S1282-90.
[45]
Zhou Y, Wei Y, Liu H, Zhang G, Wu X. Preparation and in vitro evaluation of ethosomal total alkaloids of Sophora alopecuroides loaded by a transmembrane pH-gradient method. AAPS PharmSciTech 2010; 11(3): 1350-8.
[http://dx.doi.org/10.1208/s12249-010-9509-6] [PMID: 20740333]
[46]
Srivastava N, Srivastava K, Singh AK. Formulation and evaluation of seabuckthorn leaf extract loaded ethosomal gel. Asian J Pharm Clin Res 2015; 8(5): 316-20.
[47]
Yu Z, Lv H, Han G, Ma K. Ethosomes loaded with cryptotanshinone for acne treatment through topical gel formulation. PLoS One 2016; 11(7): e0159967.
[http://dx.doi.org/10.1371/journal.pone.0159967] [PMID: 27441661]
[48]
Jin P, Yao R, Qin D, Chen Q, Du Q. Enhancement in antibacterial activities of eugenol-entrapped ethosome nanoparticles via strengthening its permeability and sustained release. J Agric Food Chem 2019; 67(5): 1371-80.
[http://dx.doi.org/10.1021/acs.jafc.8b06278] [PMID: 30624923]
[49]
Kaur P, Garg V, Bawa P, et al. Formulation, systematic optimization, in vitro, ex vivo, and stability assessment of transethosome based gel of curcumin. Asian J Pharm Clin Res 2018; 11(14): 41-7.
[http://dx.doi.org/10.22159/ajpcr.2018.v11s2.28563]
[50]
Moolakkadath T, Aqil M, Ahad A, et al. Development of transethosomes formulation for dermal fisetin delivery: Box-Behnken design, optimization, in vitro skin penetration, vesiclesskin interaction and dermatokinetic studies. Artif Cells Nanomed Biotechnol 2018; 46(sup2): 755-65.
[http://dx.doi.org/10.1080/21691401.2018.1469025] [PMID: 29730964]
[51]
Abdulbaqi IM, Darwis Y, Assi RA, Khan NAK. Transethosomal gels as carriers for the transdermal delivery of colchicine: Statistical optimization, characterization, and ex vivo evaluation. Drug Des Devel Ther 2018; 12: 795-813.
[http://dx.doi.org/10.2147/DDDT.S158018] [PMID: 29670336]
[52]
Anwar E, Ramadon D, Ardi GD. Novel transethosome containing green tea (Camellia sinensis l. kuntze) leaf extract for enhanced skin delivery of Epigallocatechin gallate: Formulation and in vitro penetration test. Int J App Pharm 2018; 10(1): 299-302.
[http://dx.doi.org/10.22159/ijap.2018.v10s1.66]
[53]
Chen ZX, Li B, Liu T, et al. Evaluation of paeonol-loaded transethosomes as transdermal delivery carriers. Eur J Pharm Sci 2017; 99: 240-5.
[http://dx.doi.org/10.1016/j.ejps.2016.12.026] [PMID: 28039091]
[54]
Azizah N, Sagita E, Iskandarsyah I. In vitro penetration tests of transethosome gel preparations containing capsaicin. Int J App Pharm 2017; 9(1): 116-9.
[http://dx.doi.org/10.22159/ijap.2017.v9s1.68_75]
[55]
Chauhan P, Kumar TB. Herbal novel drug delivery systems and Transferosomes. J Drug Deliv Ther 2018; 8(3): 162-8.
[http://dx.doi.org/10.22270/jddt.v8i3.1772]
[56]
Opatha SAT, Titapiwatanakun V, Chutoprapat R. Transfersomes: A promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics 2020; 12(9): 855.
[http://dx.doi.org/10.3390/pharmaceutics12090855] [PMID: 32916782]
[57]
Chaurasiya P, Ganju E, Upmanyu N, Ray SK, Jain P. Transfersomes: A novel technique for Transdermal drug delivery. J Drug Deliv Ther 2019; 9(1): 279-85.
[http://dx.doi.org/10.22270/jddt.v9i1.2198]
[58]
Rajan R, Jose S, Mukund VPB, Vasudevan DT. Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation. J Adv Pharm Technol Res 2011; 2(3): 138-43.
[http://dx.doi.org/10.4103/2231-4040.85524] [PMID: 22171309]
[59]
Kumar A, Nayak A, Ghatuary SK, Dasgupta S, Jain AP. Transferosome: A recent approach for transdermal drug delivery. J Drug Deliv Ther 2018; 8(5-s): 100-4.
[http://dx.doi.org/10.22270/jddt.v8i5-s.1981]
[60]
Gupta A, Aggarwal G, Singla S, Arora R. Transfersomes: A novel vesicular carrier for enhanced transdermal delivery of sertraline: Development, characterization, and performance evaluation. Sci Pharm 2012; 80(4): 1061-80.
[http://dx.doi.org/10.3797/scipharm.1208-02] [PMID: 23264950]
[61]
Prajapati ST, Patel CG, Patel CN. Transfersomes: A vesicular carrier system for Transdermal drug delivery. Asian J Biochem Pharma Res (AJBPR) 2011; 1(2): 507-24.
[62]
Bhasin B, Londhe VY. An overview of transferosomal drug delivery. IJPSR 2018; 9(6): 2175-84.
[63]
Venkatesh DN. Transferosomes: A novel technique for transdermal drug delivery. Int J Res Pharm Nano Sci 2014; 3(4): 266-76.
[64]
Rai S, Pandey V, Rai G. Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: The state of the art. Nano Rev Exp 2017; 8(1): 1325708.
[http://dx.doi.org/10.1080/20022727.2017.1325708] [PMID: 30410704]
[65]
Allaw M, Pleguezuelos-Villa M, Manca ML, et al. Innovative strategies to treat skin wounds with mangiferin: Fabrication of transfersomes modified with glycols and mucin. Nanomedicine (Lond) 2020; 15(17): 1671-85.
[http://dx.doi.org/10.2217/nnm-2020-0116] [PMID: 32677507]
[66]
Nimisha, Rizvi DA, Fatima Z, Neema, Kaur CD. Nimisha, Rizvi DA, Fatima Z, Neema, Kaur CD. Antipsoriatic and anti-inflammatory studies of Berberis aristata extract loaded Nanovesicular gels. Pharmacogn Mag 2017; 13(51)(Suppl. 3): S587-94.
[http://dx.doi.org/10.4103/pm.pm_210_17] [PMID: 29142419]
[67]
Surini S, Sarah S, Djajadisastra J. Formulation and in vitro penetration study of transfersomes gel containing gotu kola leaves extract (Centella asiatica L. Urban). J Young Pharm 2018; 10(1): 27-31.
[http://dx.doi.org/10.5530/jyp.2018.10.8]
[68]
Barone A, Cristiano MC, Cilurzo F, et al. Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery. Colloids Surf B Biointerfaces 2020; 193: 111152.
[http://dx.doi.org/10.1016/j.colsurfb.2020.111152] [PMID: 32535351]
[69]
Wu PS, Li YS, Kuo YC, Tsai SJJ, Lin CC. Preparation and evaluation of novel transfersomes combined with the natural antioxidant resveratrol. Molecules 2019; 24(3): 600.
[http://dx.doi.org/10.3390/molecules24030600] [PMID: 30743989]
[70]
Zesiorani NF, Anwar E. Transfersome gel formulation of an ethanol extract of apples (Malus domestica mill) containing antioxidants and in vitro penetration testing using franz diffusion cells. Int J App Pharm 2017; 9(1): 32.
[http://dx.doi.org/10.22159/ijap.2017.v9s1.19_24]
[71]
Fitrya F, Fithri NA, Winda M, Muharni M. Ethanol extract of Parkia speciosa Hassk. loaded transfersome: Characterization and optimization. J Pharm Pharmacogn Res 2020; 8(3): 167-76.
[72]
Jangdey MS, Gupta A, Saraf S, Saraf S. Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation. Artif Cells Nanomed Biotechnol 2017; 45(7): 1452-62.
[http://dx.doi.org/10.1080/21691401.2016.1247850] [PMID: 28050929]
[73]
Pandit AP, Omase SB, Mute VM. A chitosan film containing quercetin-loaded transfersomes for treatment of secondary osteoporosis. Drug Deliv Transl Res 2020; 10(5): 1495-506.
[http://dx.doi.org/10.1007/s13346-020-00708-5] [PMID: 31942700]
[74]
Patel R, Singh SK, Singh S, Sheth NR, Gendle R. Development and characterization of curcumin loaded transfersome for transdermal delivery. J Pharm Sci & Res 2009; 1(4): 71-80.
[75]
Raahulan S, Sanapalli BKR, Karri VVSR. Paclitaxel loaded Transferosomal vesicular drug delivery for the treatment of melanoma skin cancers. IntJResPharmSci 2019; 10(4): 2891-7.
[http://dx.doi.org/10.26452/ijrps.v10i4.1569]
[76]
Naik NJ, Abhyankar I, Darne P, Prabhune A, Madhusudhan B. Sustained transdermal release of lignans facilitated by sophorolipid based transferosomal hydrogel for cosmetic application. Int J Curr Microbiol Appl Sci 2019; 8(2): 1783-91.
[http://dx.doi.org/10.20546/ijcmas.2019.802.210]
[77]
Arun Raj A, Murali R. Formulation and evaluation of curcumin loaded transferosomal nasal in-situ gel for Alzheimer’s disease. RRJoDFDP 2019; 6(2): 19-31.
[78]
Ramadon D, Harme M, Anwar E. Formulation of transferosomal green tea (Camellia sinensis L. Kuntze) leaves extract cream and in vitro penetration study using franz diffusion cell. J Young Pharm 2018; 10(2): s63-8.
[http://dx.doi.org/10.5530/jyp.2018.2s.12]
[79]
Arora D, Khurana B, Nanda S. DoE directed optimization, development and evaluation of resveratrol loaded ultradeformable vesicular cream for topical antioxidant benefits. Drug Dev Ind Pharm 2020; 46(2): 227-35.
[http://dx.doi.org/10.1080/03639045.2020.1716373] [PMID: 31928244]
[80]
Avadhani KS, Manikkath J, Tiwari M, et al. Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage. Drug Deliv 2017; 24(1): 61-74.
[http://dx.doi.org/10.1080/10717544.2016.1228718] [PMID: 28155509]
[81]
Manca ML, Cencetti C, Matricardi P, et al. Glycerosomes: Use of hydrogenated soy phosphatidylcholine mixture and its effect on vesicle features and diclofenac skin penetration. Int J Pharm 2016; 511(1): 198-204.
[http://dx.doi.org/10.1016/j.ijpharm.2016.07.009] [PMID: 27418567]
[82]
Zaru M, Manca ML, Fadda AM, Orsini G. Glycerosomes and use thereof in pharmaceutical and cosmetic preparations for topical applications. USA Patent, 2014; 8 778,367 B2
[83]
Gupta P, Mazumder R, Padhi S. Glycerosomes: Advanced liposomal drug delivery system. Indian J Pharm Sci 2020; 82(3): 385-97.
[84]
Manca ML, Zaru M, Manconi M, et al. Glycerosomes: A new tool for effective dermal and transdermal drug delivery. Int J Pharm 2013; 455(1-2): 66-74.
[http://dx.doi.org/10.1016/j.ijpharm.2013.07.060] [PMID: 23911913]
[85]
Pleguezuelos-Villa M, Diez-Sales O, Manca ML, et al. Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis. Int J Pharm 2020; 573: 118844.
[http://dx.doi.org/10.1016/j.ijpharm.2019.118844] [PMID: 31751638]
[86]
Manca ML, Peris JE, Melis V, et al. Nano-incorporation of curcumin in polymer-glycerosomes and evaluation of their in vitro-in vivo suitability as pulmonary delivery systems. RSC Adv 2015; 5(127): 105149-59.
[http://dx.doi.org/10.1039/C5RA24032H]
[87]
Md S, Alhakamy NA, Aldawsari HM, et al. Plumbagin-loaded glycerosome gel as topical delivery system for skin cancer therapy. Polymers (Basel) 2021; 13(6): 923.
[http://dx.doi.org/10.3390/polym13060923] [PMID: 33802819]
[88]
Zhang K, Zhang Y, Li Z, Li N, Feng N. Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: Optimization, characterization, and evaluation in vitro and in vivo. Int J Nanomedicine 2017; 12(12): 3521-32.
[http://dx.doi.org/10.2147/IJN.S135749] [PMID: 28503066]
[89]
Zhu C, Zhanga Y, Wua T, et al. Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery. Acta Pharm 2022; 72(1): 135-46.
[http://dx.doi.org/10.2478/acph-2022-0006]
[90]
Moolakkadath T, Aqil M, Ahad A, et al. Preparation and optimization of fisetin loaded glycerol based soft nanovesicles by Box-Behnken design. Int J Pharm 2020; 578: 119125.
[http://dx.doi.org/10.1016/j.ijpharm.2020.119125] [PMID: 32036010]
[91]
Manca ML, Castangia I, Caddeo C, et al. Improvement of quercetin protective effect against oxidative stress skin damages by incorporation in nanovesicles. Colloids Surf B Biointerfaces 2014; 123: 566-74.
[http://dx.doi.org/10.1016/j.colsurfb.2014.09.059] [PMID: 25444664]
[92]
Lakshmi PK, Kalpana B, Domaraju P. Invasomes-novel vesicular carriers for enhanced skin permeation. SRP 2013; 4(1): 26-30.
[http://dx.doi.org/10.4103/0975-8453.135837]
[93]
Afreen U, Shailaja K. Overall review on invasomes. Res J nanosci eng 2019; 3(4): 5-9.
[94]
Saudagar RB, Bornare AS. Invasomes novel vesicular carriers for transdermal drug delivery. Inter J Univ Pharm Biosci 2016; 5(6): 2319-814.
[95]
Babaie S, Bakhshayesh ARD, Ha JW, Hamishehkar H, Kim KH. Invasome: A novel nanocarrier for transdermal drug delivery. Nanomaterials (Basel) 2020; 10(2): 341.
[http://dx.doi.org/10.3390/nano10020341] [PMID: 32079276]
[96]
Nangare S, Dugam S. Smart invasomes synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: A review. Future J PharmSci 2020; 6(1): 123.
[http://dx.doi.org/10.1186/s43094-020-00145-8]
[97]
Lakshmi PK, Mounica V, Kumar Y. Manoj, Prasanthi D. Preparation and evaluation of curcumin invasomes. Int J Drug Deliv 2014; 6(2): 113-20.
[98]
Abdelkader H, Alani AWG, Alany RG. Recent advances in non-ionic surfactant vesicles (niosomes): Self-assembly, fabrication, characterization, drug delivery applications and limitations. Drug Deliv 2014; 21(2): 87-100.
[http://dx.doi.org/10.3109/10717544.2013.838077] [PMID: 24156390]
[99]
Nagalakshmi S, Krishnaraj K, Jothy A, et al. Fabrication and characterization of herbal drug-loaded nonionic surfactant based niosomal topical gel. J Pharm Sci & Res 2016; 8(11): 1271-8.
[100]
Bhardwaj P, Tripathi P, Gupta R, Pandey S. Niosomes: A review on niosomal research in the last decade. J Drug Deliv Sci Technol 2020; 56(4): 101581.
[http://dx.doi.org/10.1016/j.jddst.2020.101581]
[101]
Kazi KM, Mandal AS, Biswas N, et al. Niosome: A future of targeted drug delivery systems. J Adv Pharm Technol Res 2010; 1(4): 374-80.
[http://dx.doi.org/10.4103/0110-5558.76435] [PMID: 22247876]
[102]
Seleci DA, Seleci M, Walter JG, Stahl F, Scheper T. Niosomes as nanoparticular drug carriers: Fundamentals and recent applications. J Nanomater 2016; 3: 1-13.
[http://dx.doi.org/10.1155/2016/7372306]
[103]
Mahale NB, Thakkar PD, Mali RG, Walunj DR, Chaudhari SR. Niosomes: Novel sustained release nonionic stable vesicular systems--an overview. Adv Colloid Interface Sci 2012; 183-184: 46-54.
[http://dx.doi.org/10.1016/j.cis.2012.08.002] [PMID: 22947187]
[104]
Rahimpour Y, Hamishehkar H. Niosomes as carrier in dermal drug delivery. In: Recent Advances in Novel Drug Carrier Systems. IntechOpen 2012; pp. 142-64.
[http://dx.doi.org/10.5772/51729]
[105]
Sharma V, Anandhakumar S, Sasidharan M. Self-degrading niosomes for encapsulation of hydrophilic and hydrophobic drugs: An efficient carrier for cancer multi-drug delivery. Mater Sci Eng C 2015; 56: 393-400.
[http://dx.doi.org/10.1016/j.msec.2015.06.049] [PMID: 26249606]
[106]
Wang Z, Liu L, Xiang S, et al. Formulation and characterization of a 3D-printed cryptotanshinone-loaded niosomal hydrogel for topical therapy of acne. AAPS PharmSciTech 2020; 21(5): 159.
[http://dx.doi.org/10.1208/s12249-020-01677-1] [PMID: 32476076]
[107]
Khazaeli P, Pardakhty A, Shoorabi H. Caffeine-loaded niosomes: Characterization and in vitro release studies. Drug Deliv 2007; 14(7): 447-52.
[http://dx.doi.org/10.1080/10717540701603597] [PMID: 17994362]
[108]
Alam MS, Ahad A, Abidin L, Aqil M, Mir SR, Mujeeb M. Embelin-loaded oral niosomes ameliorate streptozotocin-induced diabetes in Wistar rats. Biomed Pharmacother 2018; 97: 1514-20.
[http://dx.doi.org/10.1016/j.biopha.2017.11.073] [PMID: 29793314]
[109]
Raafat KM, El-Zahaby SA. Niosomes of active Fumaria officinalis phytochemicals: Antidiabetic, antineuropathic, anti-inflammatory, and possible mechanisms of action. Chin Med 2020; 15(40): 40.
[http://dx.doi.org/10.1186/s13020-020-00321-1] [PMID: 32377229]
[110]
Isnan AP, Jufri M. Formulation of niosomal gel containing green tea extract (Camellia sinensis l. kuntze) using thin-layer hydration. Int J App Pharm 2017; 9(1): 38-43.
[http://dx.doi.org/10.22159/ijap.2017.v9s1.23_28]
[111]
Ali M, Abdel Motaal A, Ahmed MA, Alsayari A, El-Gazayerly ON. An in vivo study of Hypericum perforatum in a niosomal topical drug delivery system. Drug Deliv 2018; 25(1): 417-25.
[http://dx.doi.org/10.1080/10717544.2018.1431977] [PMID: 29382233]
[112]
Barani M, Mirzaei M, Torkzadeh-Mahani M, Nematollahi MH. Lawsone-loaded Niosome and its antitumor activity in MCF-7 breast Cancer cell line: A Nano-herbal treatment for Cancer. Daru 2018; 26(1): 11-7.
[http://dx.doi.org/10.1007/s40199-018-0207-3] [PMID: 30159762]
[113]
Sharma PK, Saxena P, Jaswanth A, et al. Novel encapsulation of lycopene in niosomes and assessment of its anti-cancer activity. J Bioequivalence Bioavailab 2016; 8(5): 224-32.
[114]
Raeiszadeh M, Pardakhty A, Sharififar F, Mehrabani M, Nejat-Mehrab-Kermani H, Mehrabani M. Phytoniosome: A novel drug delivery for myrtle extract. Iran J Pharm Res 2018; 17(3): 804-17.
[PMID: 30127807]
[115]
Agarwal S, Mohamed MS, Raveendran S, Rochani AK, Maekawa T, Kumar DS. Formulation, characterization and evaluation of morusin loaded niosomes for potentiation of anticancer therapy. RSC Advances 2018; 8(57): 32621-36.
[http://dx.doi.org/10.1039/C8RA06362A]
[116]
Zarei M, Norouzian D, Honarvar B, Mohammadi M, Shamabadi HE, Akbarzadeh A. Paclitaxel loaded niosome nanoparticle formulation prepared via reverse phase evaporation method: An in vitro evaluation. Pak J Biol Sci 2013; 16(6): 295-8.
[http://dx.doi.org/10.3923/pjbs.2013.295.298] [PMID: 24498794]
[117]
Hanu P, Singh H. Formulation and Evaluation of Niosomes containing punicalagin from peels of Punica granatum. J Drug Deliv Ther 2012; 2(6): 56-7.
[118]
Negi P, Aggarwal M, Sharma G, et al. Niosome-based hydrogel of resveratrol for topical applications: An effective therapy for pain related disorder(s). Biomed Pharmacother 2017; 88: 480-7.
[http://dx.doi.org/10.1016/j.biopha.2017.01.083] [PMID: 28126673]
[119]
Manosroi A, Chutoprapat R, Abe M, Manosroi W, Manosroi J. Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds. Pharm Biol 2012; 50(2): 208-24.
[http://dx.doi.org/10.3109/13880209.2011.596206] [PMID: 22235888]
[120]
Anghore D, Kulkarni GT. Development of novel nano niosomes as drug delivery system of spermacoce hispida extract and in vitro antituberculosis activity. Curr Nanomater 2017; 2(1): 17-23.
[http://dx.doi.org/10.2174/2405461502666170314151949]
[121]
Tu YS, Sun DM, Zhang JJ, et al. Preparation and characterisation of andrographolide niosomes and its anti-hepatocellular carcinoma activity. J Microencapsul 2014; 31(4): 307-16.
[http://dx.doi.org/10.3109/02652048.2013.843727] [PMID: 24124885]
[122]
Un RN, Barlas FB, Yavuz M, et al. Phyto-niosomes: In vitro assessment of the novel nanovesicles containing marigold extract. Int J Polym Mater 2015; 64(17): 927-37.
[http://dx.doi.org/10.1080/00914037.2015.1030663]
[123]
Mohamad EA, Aly AA, Khalaf AA, et al. Evaluation of natural bioactive-derived punicalagin niosomes in skin-aging processes accelerated by oxidant and ultraviolet radiation. Drug Des Devel Ther 2021; 15: 3151-62.
[http://dx.doi.org/10.2147/DDDT.S316247] [PMID: 34321865]
[124]
Marianecci C, Rinaldi F, Di Marzio L, et al. Ammonium glycyrrhizinate-loaded niosomes as a potential nanotherapeutic system for anti-inflammatory activity in murine models. Int J Nanomedicine 2014; 9(1): 635-51.
[PMID: 24493924]
[125]
Arafa MG, Ghalwash D, El-Kersh DM, Elmazar MM. Propolis-based niosomes as oromuco-adhesive films: A randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers. Sci Rep 2018; 8(1): 18056.
[http://dx.doi.org/10.1038/s41598-018-37157-7] [PMID: 30575794]
[126]
Xu YQ, Chen WR, Tsosie JK, et al. Niosome encapsulation of curcumin: Characterization and cytotoxic effect on ovarian cancer cells. J Nanomater 2016; 2016: 6365295.
[http://dx.doi.org/10.1155/2016/6365295]
[127]
Khatoon M, Shah KU, Din FU, et al. Proniosomes derived niosomes: Recent advancements in drug delivery and targeting. Drug Deliv 2017; 24(sup1): 56-69.
[http://dx.doi.org/10.1080/10717544.2017.1384520] [PMID: 29130758]
[128]
Upadhye SS, Rafik IN. Proniosomes: A novel vesicular drug delivery system. Am J PharmTech Res 2020; 10(2): 260-73.
[http://dx.doi.org/10.46624/ajptr.2020.v10.i2.019]
[129]
Radha GV, Rani TS, Sarvani B. A review on proniosomal drug delivery system for targeted drug action. J Basic Clin Pharm 2013; 4(2): 42-8.
[http://dx.doi.org/10.4103/0976-0105.113609] [PMID: 24808669]
[130]
Morakul B, Junyaprasert VB. Proniosomes: An effective carrier for dermal and transdermal delivery. J Sci Technol 2020; 42(6): 1171-86.
[131]
Walve JR, Rane BR, Gujrathi NA. Proniosomes: A surrogate carrier for improved Transdermal drug delivery system. Int J Res Ayurveda Pharm 2011; 2: 743-50.
[132]
Yasam VR, Jakki SL, Natarajan J, Kuppuswamy G. Proniosomes: A novel nano vesicular Transdermal drug delivery. J Pharm Sci 2013; 5(8): 153-8.
[133]
Kumar K, Rai AK. Development and evaluation of Proniosomes as a promising dug carrier to improve Transdermal drug delivery. Int J Pharm 2011; 2(11): 71-4.
[134]
Lakshmi Radhika K, Dineshkumar B, Krishnakumar K. Proniosomal gel a novel approach for drug delivery: A review. Indo Am j pharm res 2017; 7(3): 7854-60.
[135]
Mehta M, Garg M. Proniosomal gel: A promising drug carrier for boswellic acids. J Med Sci (Faisalabad, Pak) 2015; 15(3): 130-4.
[http://dx.doi.org/10.3923/jms.2015.130.134]
[136]
Goyal C, Ahuja M, Sharma SK. Preparation and evaluation of anti-inflammatory activity of gugulipid-loaded proniosomal gel. Acta Pol Pharm 2011; 68(1): 147-50.
[137]
Aboali FA, Habib DA, Elbedaiwy HM, Farid RM. Curcumin-loaded proniosomal gel as a biofreindly alternative for treatment of ocular inflammation: In-vitro and in-vivo assessment. Int J Pharm 2020; 589: 119835.

Rights & Permissions Print Cite
Article Metrics
4
© 2024 Bentham Science Publishers | Privacy Policy