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Review Article

基于癌症疫苗的临床组合治疗：与检查点抑制剂及其他药物联合使用

卷 23, 期 11, 2022

发表于: 21 June, 2022

页: [1072 - 1084] 页: 13

弟呕挨: 10.2174/1389450123666220421124542

价格: $65

摘要

癌症疫苗的疗效受多种因素影响，但其中最重要的是免疫抑制肿瘤微环境，可以减弱治疗效果。治疗性癌症疫苗与其他免疫疗法或常规治疗方法的结合可以通过增加免疫监视和肿瘤免疫原性以及调节肿瘤微环境中的免疫逃逸来促进疫苗的功效。抑制性检查点在抗癌免疫应答的调节中具有重要作用，根据临床前和临床试验，免疫检查点抑制剂（ICIs）与癌症疫苗联合使用可以显着提高其治疗效果，考虑到其临床疗效低下。此外，与单药癌症疫苗或ICI相比，这些组合疗法具有可接受的安全性和最小的额外毒性。在这篇综述中，基于先前的研究结果，我们介绍并讨论了可以与治疗性癌症疫苗结合以提高其效力的治疗方法。我们的主要重点是检查点阻断疗法，这是最知名和最适用的免疫疗法。

关键词: 癌症疫苗，免疫检查点抑制剂，组合疗法，治疗癌症，肿瘤，致癌。

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