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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

阿尔茨海默病相关精神病：临床表现、发病机制和当前治疗概述

卷 19, 期 4, 2022

发表于: 09 June, 2022

页: [285 - 301] 页: 17

弟呕挨: 10.2174/1567205019666220418151914

价格: $65

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摘要

行为和精神病表现，包括攻击性、妄想和幻觉，是阿尔茨海默病 (AD)、肌萎缩性侧索硬化症、多发性硬化症和帕金森病等使人衰弱的神经疾病患者的常见合并症。 AD 相关的精神病可能与疾病预后不良有关，强调早期发现和管理是强制性的。表现是多变的，并且可能非常不同，这是一个真正的诊断问题。一些评估工具，如 BEHAVE-AD、CERAD-BRSD 和心理幻觉量表，旨在促进诊断。神经退行性变相关精神病背后的机制很复杂，尚未完全了解，这给研究人员带来了寻找适当管理方式的负担。家族史和一些遗传障碍可能在 AD 病例的这些妄想和幻觉中起决定性作用。神经元细胞的丢失、中枢神经某些区域的萎缩和突触功能障碍也可能导致这些合并症。此外，由促炎剂（如白细胞介素和肿瘤坏死因子）引发的炎症紊乱被归类为阿尔茨海默病患者出现多种精神病症状的潜在危险因素。对可能的管理工具知之甚少；因此，迫切需要进行精心设计的试验来研究可以改善这些患者护理过程的药物和非药物干预措施。本综述总结了有关 AD 相关精神病症状、病理特征、评估和管理的当前发现。

关键词: 阿尔茨海默病、精神病、发病机制、评估、管理、痴呆。

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