New Trends in Nontransplant Therapy for Acquired Aplastic Anemia

Shaoxue      Ding; Rong      Fu
doi:10.2174/1381612828666220418132432
Abstract

Aplastic anemia (AA) is a hematological disease characterized by pancytopenia and hypofunctional bone marrow hematopoiesis. Patients with AA are treated with either immunosuppressive therapy (IST) using anti-thymocyte globulin (ATG) and cyclosporine (CsA) or hematopoietic stem cell transplantation (HSCT), if a matched donor is available. The standard IST regimen for AA patients results in response rates up to 70% and even higher overall survival. However, primary and secondary failures after IST remain frequent, and to date, all attempts aiming to overcome this problem have been unfruitful. The nontransplant therapeutic options for AA have significantly expanded during the last few years. Here, we review the new trends of nontransplant therapy for AA and summarize the current therapeutic effect of AA.
Keywords: Aplastic anemia, nontransplant therapy, hematological disorder, pancytoperia, hemactopoiesis, immuno suppressive therapy.
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DOI https://dx.doi.org/10.2174/1381612828666220418132432	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286
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