Translocator Protein 18-kDa: A Promising Target to Treat Neuroinflammation-
related Degenerative Diseases

doi:10.2174/0929867329666220415120820
摘要

在神经系统中，炎症反应在生理上作为由破坏性事件触发的防御机制发生。如果调节不当，神经炎症可归因于神经胶质细胞慢性活化状态的发展，使炎症和神经元损伤永久化，从而导致神经和神经退行性紊乱。有趣的是，神经炎症与激活的神经胶质细胞中它们软骨转位蛋白（TSPO）的过表达有关。尽管TSPO在活动性疾病状态下的免疫调节机制中的确切作用尚不清楚，但它已成为促进神经保护的有希望的靶点。事实上，TSPO配体已被证明在几种神经退行性疾病的体外和体内模型中具有抵消神经炎症和神经元损伤的有益作用。特别是，神经类固醇产生的调节，细胞因子释放，自由基氧化种的代谢和细胞生物能量学似乎是观察到的影响背后的主要细胞事件。本综述旨在说明和总结TSPO配体对神经炎症和相关神经退行性机制的电势效应的最新发现，同时考虑到神经系统的一些病理学，其中炎症事件对疾病的发作和进展至关重要，并试图将光线投射到TSPO的免疫调节作用上。
关键词: 转位蛋白18kDa，TSPO，结构活性关系，选择性配体，神经炎症，小胶质细胞，星形胶质细胞，神经元。
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DOI https://dx.doi.org/10.2174/0929867329666220415120820	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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