Abstract
Adipose-derived stem cells (ADSCs) have been described as one of the most potent and accessible human adult stem cells which can be utilized in various therapeutic approaches. Due to the wide variety of cytokines and GFs secreted by them, ADSCs can be used for controlled drug release. These cells can be used for proliferation and differentiation of tissues regardless of survival conditions and immunologic problems. Because of their ability to differentiate into various lineages, ADSCs can be used in musculoskeletal problems, diabetes, heart diseases, obesity, neurologic and nephrogenic diseases, and wound healing, as well as applications in regenerative medicine such as osteogenic, cartilage, tendon, muscle, skin, CNS, cardiac and vascularization, as well as liver and even periodontal regeneration.
To maintain the highest viability and efficiency, companies that provide ADSCs should offer the best product quality to gain market share and scientists need to acquire an understanding of sources where they can find the best products available. Therefore, in this article, we have reviewed the available products, companies and the market size currently available for ADSCs. Enormous effort has been made to list the most important trials, products and companies currently existent in the field. To achieve better outcomes in scientific research, there is the need to compare the products available and choose the best option according to desired goals. Thus, this paper provides a valuable reference for those interested in the field of ADSCs and their applications.
Keywords: ADSCs, market size, regenerative medicine, clinical trials, stromal-vascular fraction (SVF), vascular endothelial growth factor (VEGF).
Graphical Abstract
[http://dx.doi.org/10.1093/asj/sjw022] [PMID: 26906346]
[http://dx.doi.org/10.3390/ijms18010208] [PMID: 28117680]
[http://dx.doi.org/10.1007/s12015-010-9193-7] [PMID: 20853072]
[http://dx.doi.org/10.1007/s00005-016-0394-x] [PMID: 27178663]
[http://dx.doi.org/10.4252/wjsc.v9.i8.107] [PMID: 28928907]
[http://dx.doi.org/10.1097/PRS.0b013e31824ecae6] [PMID: 22634645]
[http://dx.doi.org/10.1016/j.bjps.2009.10.028] [PMID: 19969517]
[http://dx.doi.org/10.1371/journal.pone.0055640] [PMID: 23383253]
[http://dx.doi.org/10.1002/jcp.21068] [PMID: 17477371]
[http://dx.doi.org/10.1136/ard.2008.101881] [PMID: 19124525]
[http://dx.doi.org/10.2741/s133] [PMID: 21196358]
[http://dx.doi.org/10.1111/j.1745-7254.2006.00449.x] [PMID: 17112416]
[http://dx.doi.org/10.1186/1479-5876-11-138] [PMID: 23742074]
[PMID: 25834689]
[PMID: 28296872]
[http://dx.doi.org/10.1186/s13287-016-0313-4] [PMID: 27095351]
[http://dx.doi.org/10.1002/stem.2226] [PMID: 26439006]
[http://dx.doi.org/10.1038/nature06188] [PMID: 17914389]
[http://dx.doi.org/10.1016/j.lfs.2020.118002] [PMID: 32585248]
[http://dx.doi.org/10.3390/cells9040991] [PMID: 32316248]
[http://dx.doi.org/10.1634/stemcells.2008-0140] [PMID: 18436858]
[http://dx.doi.org/10.1111/j.1365-2141.2005.05409.x] [PMID: 15801964]
[http://dx.doi.org/10.1089/ten.2006.0315] [PMID: 17518704]
[http://dx.doi.org/10.2174/157488810791268564] [PMID: 19941460]
[PMID: 22546620]
[http://dx.doi.org/10.1002/stem.612] [PMID: 21305671]
[http://dx.doi.org/10.1089/ten.2004.10.1456] [PMID: 15588405]
[http://dx.doi.org/10.1016/j.biomaterials.2013.10.005] [PMID: 24140042]
[http://dx.doi.org/10.4248/BR201303001] [PMID: 26273504]
[http://dx.doi.org/10.3390/ijms18102140] [PMID: 29027958]
[http://dx.doi.org/10.1155/2012/812693] [PMID: 22577397]
[http://dx.doi.org/10.1111/iwj.12569] [PMID: 26833722]
[http://dx.doi.org/10.1002/term.2495] [PMID: 28593712]
[http://dx.doi.org/10.1088/1748-6041/6/2/025011] [PMID: 21436509]
[http://dx.doi.org/10.1042/BC20070102] [PMID: 17997718]
[http://dx.doi.org/10.1272/jnms.76.56] [PMID: 19443990]
[http://dx.doi.org/10.1097/01.prs.0000256047.47909.71] [PMID: 17415234]
[http://dx.doi.org/10.1016/j.jss.2014.01.006] [PMID: 24507201]
[http://dx.doi.org/10.1159/000324921] [PMID: 21494022]
[http://dx.doi.org/10.1002/term.548] [PMID: 22294482]
[http://dx.doi.org/10.1634/stemcells.2006-0589] [PMID: 17420225]
[http://dx.doi.org/10.1089/scd.2011.0403] [PMID: 22150084]
[http://dx.doi.org/10.1634/stemcells.2007-0388] [PMID: 17901400]
[http://dx.doi.org/10.1006/jmcc.2000.1329] [PMID: 11181008]
[http://dx.doi.org/10.1161/01.CIR.0000121425.42966.F1] [PMID: 14993122]
[http://dx.doi.org/10.1016/j.bbrc.2007.09.058] [PMID: 17904522]
[http://dx.doi.org/10.1007/s12015-019-09913-3] [PMID: 31620992]
[http://dx.doi.org/10.5966/sctm.2016-0028] [PMID: 28191762]
[http://dx.doi.org/10.1016/j.stem.2008.07.003] [PMID: 18786417]
[http://dx.doi.org/10.1007/s00266-011-9835-4] [PMID: 22069062]
[http://dx.doi.org/10.1097/01.prs.0000234610.81672.e7] [PMID: 16936550]
[http://dx.doi.org/10.1097/00005537-200008000-00021] [PMID: 10942136]
[http://dx.doi.org/10.3727/096368910X507187] [PMID: 20444320]
[http://dx.doi.org/10.1097/PRS.0b013e3182589f76] [PMID: 22495217]
[http://dx.doi.org/10.2174/1574888X16666210224145104] [PMID: 33655846]
[http://dx.doi.org/10.2217/rme-2018-0161] [PMID: 30762487]
[http://dx.doi.org/10.1177/2309499019867580] [PMID: 31470759]
[http://dx.doi.org/10.1097/PRS.0000000000004506] [PMID: 29649060]
[http://dx.doi.org/10.1177/0363546517702863] [PMID: 28448728]
[http://dx.doi.org/10.1097/PRS.0000000000006867] [PMID: 32459770]
[http://dx.doi.org/10.1097/DSS.0000000000002128] [PMID: 31490301]
[PMID: 27071140]
[http://dx.doi.org/10.1111/ijd.14567] [PMID: 31297798]
[http://dx.doi.org/10.3390/jcm8070917] [PMID: 31247996]
[http://dx.doi.org/10.1155/2019/5858247] [PMID: 31191677]
[http://dx.doi.org/10.3389/fimmu.2014.00556] [PMID: 25414703]
[http://dx.doi.org/10.2337/db17-0356] [PMID: 29133512]
[http://dx.doi.org/10.1088/1748-605X/aa56f9] [PMID: 28054934]
[http://dx.doi.org/10.1039/D0NR03237A] [PMID: 32749427]