Abstract
This review highlights the chemical structures of complex glycoconjugates from protozoan and helminth parasites, etiologic agents of major world-wide infections. Several studies on parasitic diseases indicate that glycan portions linked to proteins or lipids, expressed on the cell surface or secreted by protozoa Trypanosoma, Leishmania, and by trematodes and nematodes are virulence determinants responsible for host-parasite interaction and immunomodulation in infected animals and humans. Also, the unique chemical structures of the carbohydrate moieties of these glycoconjugates indicate a specific correlation between such compounds and parasite pathogenicity, suggesting that parasite glycan biosynthesis could be an important target to novel drugs, since vaccines are nonexistent and drugs for treatment are inadequate.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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