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Current Drug Delivery

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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

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Research Article

Hyperthermia-sensitive Liposomes Containing Brucea Javanica Oil for Synergistic Photothermal-/Chemo-Therapy in Breast Cancer Treatment

Author(s): Yan Huang*, Qianying Zhang, Peipei Feng, Weihuan Li, Xiuru Li, Yongjie Li and Di Zhang

Volume 20, Issue 2, 2023

Published on: 22 June, 2022

Page: [192 - 200] Pages: 9

DOI: 10.2174/1567201819666220411115632

Price: $65

Abstract

Introduction: High mortality and limited therapeutic efficacy of clinical treatment make breast cancer a stubborn disease in women. The hypovascular issue is the main challenge needed to be overcome in breast cancer treatment.

Methods: For this purpose, hyperthermia-sensitive liposomes containing indocyanine green (ICG) and brucea javanica oil (BJO) (LP(BJO/ICG)) were constructed for near-infrared (NIR) laser-induced photothermal- /chemo-antitumor therapy. ICG, an FDA-approved photothermal agent, was employed in this study to perform photothermal therapy (PTT) effect as well as relieve hypovascular conditions in breast cancer tissue.

Results: BJO triggered release from the hyperthermia-sensitive LP (BJO/ICG) due to disassembly of liposomes under the PTT effect caused by ICG under NIR laser irradiation. It was found that mice in LP (BJO/ICG) group showed the slowest tumor growth under NIR laser irradiation, illustrating the strongest antitumor effect among all groups.

Conclusion: This responsive-release drug delivery platform can be a promising candidate for the treatment of breast cancer.

Keywords: Brucea javanica oil, ICG, hyperthermia-sensitive, liposomes, breast cancer, near-infrared.

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